Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB38 (P57729) - Overview - Molecular Target Synopsis

Protein


RAB38, Ras-related protein Rab-38
UniProt P57729

Also Known as RAB38_HUMAN, RAB38

May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Interacts with ANKRD27 (PubMed:19403694).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB38 is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle, melanosome, melanosome membrane, phagosome, phagosome membrane.
GO terms: RAB38 is active in the following subcellular-locations: cytosol, early endosome, endoplasmic reticulum, lysosome, melanosome, melanosome membrane, membrane, mitochondria-associated endoplasmic reticulum membrane, mitochondrion, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB38 has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, UACC_257, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 501A, 928 mel, SK23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, SK-N-SH

(see details)

3D Structures


At greater than 75% identity similarity to RAB38 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis