Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB38 (P57729) - Overview - Molecular Target Synopsis


RAB38, Ras-related protein Rab-38
UniProt P57729

Also Known as RAB38_HUMAN, RAB38

May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Interacts with ANKRD27 (PubMed:19403694).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RAB38 is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle, melanosome, melanosome membrane, phagosome, phagosome membrane.
GO terms: RAB38 is active in the following subcellular-locations: cytosol, early endosome, endoplasmic reticulum, lysosome, melanosome, melanosome membrane, membrane, mitochondria-associated endoplasmic reticulum membrane, mitochondrion, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, trans-Golgi network.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB38 has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, UACC_257, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 501A, 928 mel, SK23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, SK-N-SH

(see details)

3D Structures

At greater than 75% identity similarity to RAB38 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis