RAB38 (P57729) - Overview - Molecular Target Synopsis
RAB38, Ras-related protein Rab-38
Also Known as RAB38_HUMAN, RAB38
May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Interacts with ANKRD27 (PubMed:19403694).
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UniProt: RAB38 is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle, melanosome, melanosome membrane, phagosome, phagosome membrane.
GO terms: RAB38 is active in the following subcellular-locations: cytosol, early endosome, endoplasmic reticulum, lysosome, melanosome, melanosome membrane, membrane, mitochondria-associated endoplasmic reticulum membrane, mitochondrion, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, trans-Golgi network.