Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HUNK (P57058) - Overview - Molecular Target Synopsis

Protein


HUNK, Hormonally up-regulated neu tumor-associated kinase
Enzyme Classification 2.7.11.1
UniProt P57058

Also Known as HUNK_HUMAN, HUNK, MAKV

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: HUNK is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HUNK has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, TK_10, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H520, SJCRH30, HM7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


HUNK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MFM223, SUM44. (see details)

3D Structures


At greater than 35% identity similarity to HUNK there are:
106 structures (176 chains) solved
78 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

HUNK is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (4Y5Q_A),
XIN/NINTEDANIB (5MAF_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HUNK has been screened with 84 compounds (90 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (8 bioactivities). (see details)