Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC37A1 (P57057) - Overview - Molecular Target Synopsis

Protein


SLC37A1, Glucose-6-phosphate exchanger SLC37A1
UniProt P57057

Also Known as G6PT2_HUMAN, SLC37A1, G3PP

Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
533ENSG00000160190ENST00000398341, ENST00000352133ENSP00000381383, ENSP00000344648P57057-1

Sub-cellular localization


UniProt: SLC37A1 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: SLC37A1 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of endoplasmic reticulum membrane, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC37A1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HT29, MCF7, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, UKE-1, HCC2688

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD20-positive B cell, GM12878, SK-N-SH

(see details)