Molecular Target Synopsis
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BACE1 (P56817) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed578
Chains with at least one site assessed as druggable using the strict criteria548
Chains with at least one site assessed as druggable using the relaxed criteria578


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4H3I_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 69.4 54.2 Yes Yes
2 empty 2.18 64.1 20.9 No No
3 empty 2.12 62.2 15.8 No No
4 empty 2.23 64.8 14.2 No No
5 empty 2.41 63 14.4 No No
6 empty 1.97 72.9 10.5 No No
7 empty 2.11 61.9 13.1 No No
8 empty 2.03 71.1 14.3 No No
9 empty 2.39 64.8 14.4 No No
10 empty 2.04 59.5 12 No No
4ZSQ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 71.1 54.5 Yes Yes
2 empty 2.48 64.8 25.8 No No
3 empty 2.23 65.3 20.7 No No
4 empty 2.14 60.6 23.8 No No
5 empty 2.5 73.4 13 No No
6 empty 2.18 58.3 18.4 No No
7 empty 2.26 71.5 10.2 No No
8 empty 2.1 67.2 12.2 No No
9 empty 2.1 64.3 15.3 No No
10 empty 1.86 62 14.1 No No
2VKM_D Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 71.2 53.3 Yes Yes
2 empty 2.52 65.8 25 No No
3 empty 2.18 59 20 No No
4 empty 2.26 70.8 18.5 No No
5 empty 2.24 64.6 19.6 No No
6 empty 2.11 62.7 14.6 No No
7 empty 2.63 56.1 17.5 No No
8 empty 2.15 65.3 12.3 No No
9 empty 2.12 58.4 15.6 No No
10 empty 1.76 59.3 16.2 No No
3LPK_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 71.7 52.4 Yes Yes
2 empty 2.21 61.7 19.9 No No
3 empty 2.16 58.3 20.6 No No
4 empty 2.13 73.5 11.7 No No
5 empty 2.02 67.8 11.4 No No
6 empty 2.09 61.5 13.3 No No
7 empty 2.03 65 12 No No
8 empty 2.37 67.8 11.9 No No
9 empty 2.2 62 10.4 No No
10 empty 2.11 69.9 9.2 No No
4TRY_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 69.7 43.2 Yes Yes
2 empty 1.81 70.8 30.2 No No
3 empty 2.1 64.5 19.1 No No
4 empty 2.64 63.7 18.5 No No
5 empty 2.22 64.4 21.7 No No
6 empty 2.25 67.7 11.9 No No
7 empty 2.13 62.2 18.2 No No
8 empty 2.15 67.5 9 No No
9 empty 2.46 65.7 13 No No
10 empty 2.11 63.5 15.6 No No
4B77_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 69.7 39.1 Yes Yes
2 empty 2.02 79.7 20.3 Yes Yes
3 empty 2.34 70.1 15.7 No No
4 empty 2.24 59.7 19.2 No No
5 empty 1.99 65.4 13 No No
6 empty 2.16 61.1 15.1 No No
7 empty 2.08 60.2 12.1 No No
8 empty 2.28 65.3 16.6 No No
9 empty 2.21 69.1 10.6 No No
10 empty 2.09 60.6 14.2 No No
4FSE_E Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 69.4 54.5 Yes Yes
2 empty 2.24 67.1 19.6 No No
3 empty 2.18 63.3 18.9 No No
4 empty 2.19 63.6 22.7 No No
5 empty 2.25 59.6 17 No No
6 empty 2.14 58.8 19.9 No No
7 empty 1.93 67.9 16.1 No No
8 empty 2.21 72.6 11.9 No No
9 empty 2.03 66.6 13 No No
10 empty 2.28 61.8 16.9 No No
4RCE_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.26 75 41.9 Yes Yes
2 empty 2.25 64.5 20.5 No No
3 empty 2.14 64 16.9 No No
4 empty 2.33 69 17.3 No No
5 empty 2.16 60.8 16.7 No No
6 empty 2.41 65.3 14.2 No No
7 empty 2.01 72.8 11.4 No No
8 empty 1.97 62.7 15 No No
9 empty 2.49 67.4 15.7 No No
10 empty 1.94 68.5 10.1 No No
5I3X_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 68.7 26.5 Yes Yes
2 empty 2.03 58.4 19.8 No No
3 empty 1.95 61.9 18.7 No No
4 empty 2.27 65.8 16.6 No No
5 bound 1.87 78.5 16.4 No No
6 empty 1.85 54.8 16.8 No No
7 empty 2.17 55.7 17.5 No No
8 empty 2.15 63.1 11.6 No No
9 empty 2.59 65.7 12.5 No No
10 empty 1.95 65.6 13.1 No No
2VJ6_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.32 72.3 42.6 Yes Yes
2 empty 2.34 70.4 23.4 No No
3 empty 2.23 59.4 21 No No
4 empty 2.29 64.3 21.2 No No
5 empty 2.14 61.4 13.1 No No
6 empty 1.95 57.1 12.3 No No
7 empty 2.09 63.6 13.3 No No
8 empty 2.63 70.4 13.6 No No
9 empty 2.44 62.9 13.3 No No
10 empty 2.36 63.6 12.4 No No
4B0Q_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 71.4 53.8 Yes Yes
2 empty 2.38 70.7 24.3 No No
3 empty 2.32 60.5 17.6 No No
4 empty 2.42 64 15.9 No No
5 empty 2.33 69.4 10.8 No No
6 empty 2.59 66.3 16.3 No No
7 empty 2.01 62.1 12.5 No No
8 empty 2.18 59.6 15.8 No No
9 empty 2.19 61.9 12.7 No No
10 empty 2.2 67.4 12.8 No No
5HDZ_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 72.9 39.9 Yes Yes
2 empty 2.15 62.8 29.1 No No
3 empty 2.1 73.3 26.4 No No
4 empty 2.54 62.7 25.6 No No
5 empty 2.22 63.6 16.5 No No
6 empty 1.95 60.3 23.6 No No
7 empty 2.05 64.5 15.8 No No
8 empty 2.09 70.9 11.2 No No
9 empty 2.08 66.3 8.1 No No
10 empty 1.92 61.3 13.1 No No
1SGZ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 74.4 46.6 Yes Yes
2 empty 2.26 64.1 31 No No
3 empty 2.62 67.7 24 No No
4 empty 2.23 65.4 15.2 No No
5 empty 2.21 56.8 21.3 No No
6 empty 2.42 70.8 17.2 No No
7 empty 1.88 68.2 17.1 No No
8 empty 1.95 67.7 11.4 No No
9 empty 2.18 71.8 12.4 No No
10 empty 2.14 67 12.7 No No
1W50_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 71.2 48.2 Yes Yes
2 empty 2.42 67.3 17.1 No No
3 empty 2.23 65.3 16.3 No No
4 empty 2.2 66.9 18.3 No No
5 empty 2.52 66.4 20.2 No No
6 empty 2.29 64.8 18 No No
7 empty 2.55 65.1 13.4 No No
8 empty 2.51 66.4 15.5 No No
9 empty 2.07 62.2 14.4 No No
10 empty 1.87 54.7 19.7 No No
3UQR_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 69.4 54.1 Yes Yes
2 empty 2.36 68 14.3 No No
3 empty 2.35 57.5 25.4 No No
4 empty 2.25 64.2 11.7 No No
5 empty 2.53 64.7 15.9 No No
6 empty 2.12 62.9 14.1 No No
7 empty 1.96 66.8 14.1 No No
8 empty 2.13 65.7 18.8 No No
9 empty 2.11 63.5 15.8 No No
10 empty 2.65 68.4 12.7 No No
4FCO_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.36 69.5 38.8 Yes Yes
2 empty 1.93 60.7 20.8 No No
3 empty 2.15 62.9 18.3 No No
4 empty 2.33 64.2 17.9 No No
5 empty 1.99 66 10.7 No No
6 empty 1.84 64.6 11.6 No No
7 empty 2.07 63.4 9.8 No No
8 empty 1.97 59.7 12.6 No No
9 empty 1.94 59.4 15.3 No No
10 empty 2.21 54.7 10.6 No No
5ENK_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 71.3 43 Yes Yes
2 empty 2.37 69.2 18.2 No No
3 empty 1.61 64.6 17.8 No No
4 empty 2.13 67.2 12.2 No No
5 empty 2.04 69.5 15.7 No No
6 empty 2.38 72.8 10.8 No No
7 empty 2.46 69.6 10.4 No No
8 empty 2.19 65.3 21 No No
9 empty 2.59 71.7 11.3 No No
10 bound 2.09 57.3 8.5 No No
4FSE_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 70.3 55.1 Yes Yes
2 empty 2.16 62.8 22.1 No No
3 empty 1.98 60.8 19 No No
4 empty 2.47 66 16.9 No No
5 empty 2.13 71 11.8 No No
6 empty 2.02 64.5 17.7 No No
7 empty 2.04 69.5 10 No No
8 empty 2.31 61 17.1 No No
9 empty 2.24 60 14.4 No No
10 empty 2.5 65.2 15.5 No No
4DJW_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 71.1 53.6 Yes Yes
2 empty 2.52 69.9 23.8 No No
3 empty 2.21 66.7 18.9 No No
4 empty 2.12 61.6 16.8 No No
5 empty 2.24 62 16.1 No No
6 empty 2.11 70.2 11.5 No No
7 empty 2.11 64.4 12.6 No No
8 empty 2.12 64.5 10.6 No No
9 empty 2 66.7 11.1 No No
10 empty 1.98 61.2 12.9 No No
1YM2_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 67.8 55.2 Yes Yes
2 empty 2.05 66.6 24.2 No No
3 empty 2.1 61.3 19.6 No No
4 empty 2.36 54.1 14.3 No No
5 empty 2.28 68.8 13 No No
6 empty 2.15 64.5 19.6 No No
7 empty 2.37 61.3 15.3 No No
8 empty 2.49 63.9 11.2 No No
9 empty 2.44 64.5 14.1 No No
10 empty 2.17 61.8 11.4 No No
2QMG_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 69.9 54.7 Yes Yes
2 empty 2.19 64.3 19.1 No No
3 empty 2.21 58.8 19.4 No No
4 empty 2.47 71.5 14.7 No No
5 empty 2.17 71.9 11.7 No No
6 empty 2.15 63 12.9 No No
7 empty 2 68.4 11.6 No No
8 empty 2.14 60.1 12.6 No No
9 empty 2.16 71.4 11.7 No No
10 empty 2.05 60.9 13.8 No No
4PZW_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 69.6 53.3 Yes Yes
2 empty 2.2 64 27.2 No No
3 empty 2.17 67.6 29.6 No No
4 empty 2.18 66.4 16 No No
5 empty 2.28 67.4 18.1 No No
6 empty 2.47 70.6 18.2 No No
7 empty 2.48 66.7 18.5 No No
8 empty 1.9 56 14.6 No No
9 empty 2.06 56.9 14.4 No No
10 empty 2.31 64.7 13.4 No No
3UQP_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 70.5 39.6 Yes Yes
2 empty 2.57 69.1 26.1 No No
3 empty 2.34 67.1 22.4 No No
4 empty 2.31 66.7 13.9 No No
5 empty 2.53 68.5 17.7 No No
6 empty 2.1 70.2 11 No No
7 bound 2.16 54.5 12.1 No No
8 empty 2.06 55 12.6 No No
9 empty 2.31 74.8 10.1 No No
10 empty 2.21 66.2 15.4 No No
4K8S_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 70.2 48.9 Yes Yes
2 empty 2.17 67.4 23.7 No No
3 empty 2.22 58.5 20.5 No No
4 empty 2.17 66.8 17.3 No No
5 empty 2.08 65.4 12.4 No No
6 empty 2.4 63.8 13.8 No No
7 empty 2.52 68.1 9.6 No No
8 empty 2.36 64 17 No No
9 empty 2.55 73.4 9.1 No No
10 empty 2.26 64.4 15.7 No No
4LXM_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 70.3 55.4 Yes Yes
2 empty 2.04 57.5 20.5 No No
3 empty 2.22 71.4 16.7 No No
4 empty 2.3 61.3 14.2 No No
5 empty 2.11 68.9 12.8 No No
6 empty 2.48 66.2 13.1 No No
7 empty 2.43 62.2 14.9 No No
8 empty 2.2 67.6 10.5 No No
9 empty 2.02 64.4 12.7 No No
10 empty 2.27 67.8 11.7 No No
3VV6_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 70.4 22.8 Yes Yes
2 bound 2.06 62 29.2 No No
3 empty 2.22 64.7 14.8 No No
4 empty 1.9 58.4 14 No No
5 empty 2.07 62 11.9 No No
6 empty 2.45 62.8 12.2 No No
7 empty 2.33 66 13.2 No No
8 empty 1.93 63.8 10.1 No No
9 empty 1.85 62.9 9.9 No No
10 empty 2.04 55.1 11.9 No No
3NSH_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 70.1 54.8 Yes Yes
2 empty 1.98 65.3 23.6 No No
3 empty 2.19 66.7 16.8 No No
4 empty 2.29 62.3 15.9 No No
5 empty 2.39 66.1 15 No No
6 empty 2.19 67.6 15.1 No No
7 empty 2.33 62.5 12.2 No No
8 empty 2.42 69.8 10.1 No No
9 empty 2.02 64.8 12.2 No No
10 empty 2.55 69.3 14.7 No No
2FDP_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 71.6 52.5 Yes Yes
2 empty 2.34 62.3 20.6 No No
3 empty 2.73 64.4 26.4 No No
4 empty 2.26 70 13.3 No No
5 empty 2.17 69.6 12.5 No No
6 empty 2.64 69.4 10.3 No No
7 empty 2.15 56.6 16.9 No No
8 empty 2.54 66 12.1 No No
9 empty 2.14 63.4 11.5 No No
10 empty 2.21 68 9.5 No No
3K5F_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 70.9 53.8 Yes Yes
2 empty 2.14 56.9 20.4 No No
3 empty 2.25 59.5 15 No No
4 empty 2.06 70 13.3 No No
5 empty 2.15 66.6 16.1 No No
6 empty 2.39 62.6 14.1 No No
7 empty 2.39 68.2 10.9 No No
8 empty 2.22 58.7 13.6 No No
9 empty 2.13 59.5 13.4 No No
10 empty 2.06 64.9 10.2 No No
4I11_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 66.8 65 Yes Yes
2 empty 2.25 67.7 21.2 No No
3 empty 2.05 57.3 14.1 No No
4 empty 2.09 54.9 11.4 No No
5 empty 2.4 68.4 13.7 No No
6 empty 2.14 65.2 10 No No
7 empty 2.17 67.3 12.1 No No
8 empty 2.3 57.1 14 No No
9 empty 2.57 58 15 No No
10 empty 2.24 70.6 9.3 No No
5I3Y_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 75.3 31.4 Yes Yes
2 empty 2.3 58.3 22.5 No No
3 empty 2.21 74.6 24.7 No No
4 empty 2.35 67.3 15.2 No No
5 empty 2.16 64.5 17.6 No No
6 empty 2.15 67.2 21.2 No No
7 empty 2.65 57.6 19.7 No No
8 empty 2.47 63.5 13.1 No No
9 empty 2.37 64.6 11 No No
10 empty 1.8 64.8 12.8 No No
4FRI_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.21 73 47.4 Yes Yes
2 empty 2.3 62.2 15.6 No No
3 empty 1.8 59.9 19.6 No No
4 empty 2.38 69.5 12.7 No No
5 empty 2.02 60.1 17.6 No No
6 empty 2.58 63.8 21.1 No No
7 empty 2.09 67.9 9.2 No No
8 empty 2.12 61.5 12.6 No No
9 empty 1.88 62 12.4 No No
10 empty 2.37 71.6 13.2 No No
4J1I_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 68.5 30.1 Yes Yes
2 empty 2.07 65.2 34.5 No No
3 empty 2.35 69.3 14.5 No No
4 empty 2.42 68 23.1 No No
5 empty 2.36 73.7 13.3 No No
6 empty 2.44 62.9 15.2 No No
7 empty 2.18 59.1 19.8 No No
8 empty 2.07 67.4 12.3 No No
9 empty 1.93 65.3 14.5 No No
10 empty 2.04 66.1 12.8 No No
1XN3_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 69.8 53.4 Yes Yes
2 empty 2.63 66.2 23.4 No No
3 empty 2.22 58.7 18.4 No No
4 empty 2.05 65.5 15.6 No No
5 empty 2.62 57.5 13.7 No No
6 empty 2.14 72.9 12.6 No No
7 empty 2.14 64 12.9 No No
8 empty 2.22 64.8 17.2 No No
9 empty 1.96 62.2 13.6 No No
10 empty 2.27 66.7 11.6 No No
6BFE_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 73.8 38.8 Yes No
2 bound 2.14 57.9 32.3 No No
3 empty 2.15 61.2 20.9 No No
4 empty 2.28 59 17.5 No No
5 empty 1.97 53.8 16.8 No No
6 empty 2.02 67.2 12.6 No No
7 empty 2.32 55.3 14.6 No No
8 empty 2.02 61.7 13.7 No No
9 empty 2.03 60.8 14.5 No No
10 empty 2 62.7 11 No No
4DJU_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 66.9 54.1 Yes Yes
2 empty 2.13 60.5 20.4 No No
3 empty 2.2 65 12.4 No No
4 empty 1.97 62.1 13.2 No No
5 empty 2.09 66.2 11.6 No No
6 empty 1.95 61.7 12.6 No No
7 empty 2.02 54.3 14 No No
8 empty 1.95 55.4 11.6 No No
9 empty 2.36 66 13.3 No No
10 empty 2.04 61.2 10.8 No No
3CIB_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 71.4 53.9 Yes Yes
2 empty 2.52 67.7 21 No No
3 empty 1.92 63.4 20.3 No No
4 empty 2.02 63.4 20.8 No No
5 empty 2.3 62.6 18.1 No No
6 empty 1.98 70.5 11.7 No No
7 empty 2.04 67 10.7 No No
8 empty 2.11 59.4 14.1 No No
9 empty 1.91 71.6 14.7 No No
10 empty 2.52 66.7 12.1 No No
4J0Y_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 69.7 46 Yes Yes
2 empty 2.03 58.3 28.9 No No
3 empty 2.28 67.9 17.9 No No
4 empty 2.22 59.7 17.4 No No
5 empty 1.97 56.9 14.5 No No
6 empty 2.42 76.3 13.5 No No
7 empty 2.34 60 19.9 No No
8 empty 1.91 65.4 12 No No
9 bound 2.16 66.8 16.4 No No
10 empty 2.33 62.2 13.7 No No
3UDJ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 69.8 47 Yes Yes
2 empty 2.18 69.4 27.5 No No
3 empty 2.19 58.7 21.6 No No
4 empty 2 62.7 21.8 No No
5 empty 2.35 68.8 13.3 No No
6 empty 2.21 60.6 17.6 No No
7 empty 2.16 64.8 12.9 No No
8 empty 1.88 75.2 9.6 No No
9 empty 2.07 59.4 18 No No
10 empty 1.93 62.5 12.7 No No
5HE7_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 72.8 25.4 Yes Yes
2 empty 2.2 61.7 29.8 No No
3 empty 2 71.5 27.1 No No
4 empty 2.1 66.7 20 No No
5 empty 2.3 65 18.8 No No
6 empty 2.24 62.8 20.1 No No
7 empty 2.18 73.1 12.1 No No
8 empty 2.45 65.1 14.1 No No
9 empty 2.02 65.3 10.9 No No
10 empty 2.01 62.6 16.2 No No
3BRA_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 71.8 49 Yes Yes
2 empty 2.33 66.2 24.1 No No
3 empty 2.32 63.6 19.7 No No
4 empty 2.2 64.7 23.8 No No
5 empty 2.33 61.8 18 No No
6 empty 2.38 63.8 14.9 No No
7 empty 2.55 62.7 17.5 No No
8 empty 2.03 62.6 14.5 No No
9 empty 2.28 65.6 14.6 No No
10 empty 2.37 73.8 9.5 No No
3INF_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 64.6 40.3 Yes No
2 bound 1.82 68.8 36.7 No No
3 empty 2.24 64.9 22.5 No No
4 empty 2.39 67.6 17.8 No No
5 empty 2.21 60.7 19 No No
6 empty 2.16 65.5 16.6 No No
7 empty 2.26 74.1 15.4 No No
8 empty 2.19 61.7 14.4 No No
9 empty 1.98 59.2 13.9 No No
10 empty 2.51 71.8 10.4 No No
2VJ9_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 71.3 54.3 Yes Yes
2 empty 2.34 68.4 35.2 No No
3 empty 2.25 62.5 14.7 No No
4 empty 2.46 62.1 20.9 No No
5 empty 2.39 60 21.9 No No
6 empty 2.21 62.9 13.6 No No
7 empty 2.56 69.9 13.3 No No
8 empty 2.21 59.8 14.3 No No
9 empty 2.27 67.2 12.3 No No
10 empty 1.87 63.8 10 No No
1M4H_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 70.9 54.5 Yes Yes
2 empty 2.54 64.9 17.3 No No
3 empty 2.27 65.4 21 No No
4 empty 2.2 62.2 16.3 No No
5 empty 2.17 74.6 11.4 No No
6 empty 2.32 61.1 14.3 No No
7 empty 1.98 62.2 16 No No
8 empty 1.82 62.8 14 No No
9 empty 2.03 68.6 9.5 No No
10 empty 1.93 71.8 10.1 No No
5EZZ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 69.5 54.6 Yes Yes
2 empty 2.37 63.5 28 No No
3 empty 2.35 65.8 21.1 No No
4 empty 2.31 58.9 17.6 No No
5 empty 2.08 58.3 16.4 No No
6 empty 2.66 61 21.6 No No
7 empty 2.07 62.8 14.2 No No
8 empty 2.12 61.2 14.6 No No
9 empty 1.99 65.1 10.8 No No
10 empty 2.25 60.7 15.6 No No
3UDN_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 70.2 48.2 Yes Yes
2 empty 1.94 72.7 27.5 No No
3 empty 2.18 58.1 19.4 No No
4 empty 1.96 64.4 22.7 No No
5 empty 2.26 69.9 15 No No
6 empty 2.15 60 19.6 No No
7 empty 2.15 68.1 12.4 No No
8 empty 2.13 64.4 13.3 No No
9 empty 2.12 64.5 10.3 No No
10 empty 2.38 51.8 13.2 No No
3DUY_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.34 70.6 54.1 Yes Yes
2 empty 2.17 64.9 20.9 No No
3 empty 2.65 67.3 18 No No
4 empty 2.31 65.3 17.1 No No
5 empty 2.27 62.2 17.3 No No
6 empty 2.55 61.8 14.8 No No
7 empty 1.85 65.1 12 No No
8 empty 2.04 70 14.6 No No
9 empty 1.83 60.9 15.4 No No
10 empty 2.54 68.4 12 No No
3VEU_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.32 68.3 44.5 Yes Yes
2 empty 2.53 69.6 33 No No
3 empty 2.01 75.1 25.4 No No
4 empty 2.26 66 22 No No
5 empty 2.03 57.9 20.1 No No
6 empty 1.99 67.8 10.7 No No
7 empty 2.58 70.4 10.4 No No
8 empty 2.28 61.8 15.4 No No
9 empty 2.06 56.8 13.7 No No
10 empty 2.47 61.9 13.6 No No
3H0B_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 69.3 52.8 Yes Yes
2 empty 2.14 63.2 20.3 No No
3 empty 2.02 66.6 20.7 No No
4 empty 2.19 61.9 23.9 No No
5 empty 2.45 64.8 15.3 No No
6 empty 2.1 63.8 11.1 No No
7 empty 2.49 66.6 15.5 No No
8 empty 2.04 63.9 13.2 No No
9 empty 2.14 60.3 11.2 No No
10 empty 2.28 60.1 12.7 No No
4FM8_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 67.4 49.2 Yes Yes
2 empty 2.02 67.7 28.3 No No
3 empty 2.17 60.7 19.9 No No
4 empty 1.92 62 22.7 No No
5 empty 2.21 70.3 11.6 No No
6 empty 2.17 60.3 19 No No
7 empty 2.14 70.5 12.6 No No
8 empty 2.03 67 10.6 No No
9 empty 2.4 68.4 13.2 No No
10 empty 1.95 56.4 13 No No
3IXK_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 73 53.3 Yes Yes
2 empty 2.23 64 24.3 No No
3 empty 2.23 67.6 17.1 No No
4 empty 2.44 63.2 16.8 No No
5 empty 2.6 67.5 14.8 No No
6 empty 2.29 68.1 13.7 No No
7 empty 2.18 63.3 19 No No
8 empty 2.55 65.9 11.3 No No
9 empty 2.04 64.7 12 No No
10 empty 2.52 68.1 10.9 No No
3N4L_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 70.1 52.2 Yes Yes
2 empty 2.07 64.7 20.1 No No
3 empty 2.44 70.8 17.2 No No
4 empty 2.14 64 16.3 No No
5 empty 2.17 71.1 12.5 No No
6 empty 2.33 68.7 14.4 No No
7 empty 2.27 58.6 18.9 No No
8 empty 2.33 70.8 12.1 No No
9 empty 2.41 67.6 10.6 No No
10 empty 2.36 56.9 20.5 No No
2F3E_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 70.2 54.3 Yes Yes
2 empty 2.08 65.1 23.9 No No
3 empty 2.18 57.8 19.7 No No
4 empty 2.24 62.6 15.5 No No
5 empty 2.23 68.8 12.9 No No
6 empty 2.43 64.2 13.6 No No
7 empty 2.38 65 16.1 No No
8 empty 2.38 70 9.3 No No
9 empty 2.05 57.3 13.2 No No
10 empty 2.41 67.8 10.8 No No
5YGY_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 69.8 47.6 Yes Yes
2 empty 2.35 67 26.6 No No
3 empty 2.37 70.3 18.3 No No
4 empty 2.45 60.4 24.8 No No
5 empty 2.12 65.7 17.4 No No
6 empty 2.08 64.1 13 No No
7 empty 1.91 66 15.1 No No
8 empty 2.12 66.3 10.9 No No
9 empty 2.43 72.9 11 No No
10 empty 2.43 69.2 14.5 No No
5HDV_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 70.2 23.8 Yes Yes
2 empty 2.19 62.1 29.2 No No
3 empty 1.98 73.7 27.9 No No
4 empty 2.2 65.6 18.9 No No
5 empty 2.45 63.1 16.2 No No
6 empty 2.16 72.4 11.3 No No
7 empty 2.43 63.4 16.4 No No
8 empty 2.11 64.3 11.3 No No
9 empty 2.02 66.7 12.3 No No
10 empty 2.01 61 16.5 No No
2OHN_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 72.9 47.8 Yes Yes
2 empty 2.41 62.4 25 No No
3 empty 2.28 66.7 16.4 No No
4 empty 2.13 60.2 17.1 No No
5 empty 2.37 64.1 14.6 No No
6 empty 2 58.7 18.7 No No
7 empty 2.16 65 10.9 No No
8 empty 2.25 59.5 17.2 No No
9 empty 2.23 68.7 10.6 No No
10 empty 1.98 67.5 12.5 No No
4DPF_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.39 67.9 42.3 Yes Yes
2 empty 2.02 75.8 26.9 No No
3 empty 2.27 72.9 23.1 No No
4 empty 2.23 58.9 20 No No
5 empty 2.2 62.9 14.9 No No
6 empty 2.31 60.4 13.1 No No
7 empty 2.54 71.4 12.6 No No
8 empty 2.3 65.6 12.9 No No
9 empty 2.01 63.1 12.7 No No
10 empty 2.37 69 11.2 No No
3SKG_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 71 54.7 Yes Yes
2 empty 2.09 63.7 20.2 No No
3 empty 2.27 62.8 16.6 No No
4 empty 2.16 62.5 14.7 No No
5 empty 1.9 71.2 17.6 No No
6 empty 2.74 73.8 16.7 No No
7 empty 2.17 61 16 No No
8 empty 2.17 67.4 12.3 No No
9 empty 2.17 64.5 13.6 No No
10 empty 2.05 54.3 15.4 No No
4DV9_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 68 52 Yes Yes
2 empty 2.29 64.3 27.3 No No
3 empty 2.36 66 14.6 No No
4 empty 2.58 65.5 13 No No
5 empty 2.21 62.2 14.2 No No
6 empty 2.04 68.4 12.4 No No
7 empty 2.36 60.6 17.5 No No
8 empty 2.16 98.8 0 Yes No
9 empty 1.72 58.4 12.7 No No
10 empty 2.13 65.3 10.5 No No
4ACX_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 71.2 38.4 Yes Yes
2 empty 2.3 71.3 23.2 No No
3 empty 2.25 63.2 18.4 No No
4 empty 1.8 74.6 14.9 No No
5 empty 2.29 61.6 20.8 No No
6 empty 1.93 62.1 13.5 No No
7 empty 2.06 60.4 15.6 No No
8 empty 2.21 62.5 19.4 No No
9 empty 2.18 60.1 12.6 No No
10 empty 1.9 67.8 12.6 No No
3VV8_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.19 70 41 Yes Yes
2 empty 2.29 68.5 15.9 No No
3 empty 2.06 66.9 13.3 No No
4 empty 2.04 65.7 14.1 No No
5 empty 1.71 62 13.7 No No
6 empty 2.05 64.1 11.3 No No
7 empty 2.48 66.4 12.7 No No
8 empty 1.84 60.7 11 No No
9 empty 2.39 69 13.3 No No
10 empty 1.88 58.8 13.8 No No
2P83_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 70.5 41.8 Yes Yes
2 empty 1.93 61.4 23.8 No No
3 empty 2.06 55.3 21.9 No No
4 empty 2.19 60.1 14.9 No No
5 empty 2.13 63.1 15.5 No No
6 empty 1.89 60.4 16.4 No No
7 empty 2.01 64.8 11.9 No No
8 empty 2.41 60.8 12 No No
9 empty 2.02 61.8 15.5 No No
10 empty 1.78 57.5 13.7 No No
5HE5_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 72.7 37.1 Yes Yes
2 empty 2.13 68.5 34.8 No No
3 empty 2.24 66.4 19.7 No No
4 empty 2.27 61.9 17.1 No No
5 bound 2.36 67.4 20.5 No No
6 empty 2.12 72 10.9 No No
7 empty 2.01 66 11.3 No No
8 empty 2.03 61.7 16.7 No No
9 empty 1.9 59.3 12.9 No No
10 empty 2.21 60.9 15.1 No No
3KN0_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 58.3 35.8 Yes No
2 bound 1.82 68.9 27.6 No No
3 empty 2.18 60.5 21.5 No No
4 empty 1.98 57.1 16.7 No No
5 empty 2.31 65.7 11.1 No No
6 empty 2.03 60.5 13.9 No No
7 empty 1.99 64.1 13 No No
8 empty 1.97 61.5 13.3 No No
9 empty 2.09 66.6 11 No No
10 empty 2.16 67.9 13.9 No No
3UQW_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 72.9 55.1 Yes Yes
2 empty 2.27 66.6 17.9 No No
3 empty 2.18 64.3 19.1 No No
4 empty 2.38 59.7 32.5 No No
5 empty 2.23 68.6 13.7 No No
6 empty 2.14 66.7 17.6 No No
7 empty 2.32 72 13.1 No No
8 empty 2.17 66.7 9.1 No No
9 empty 1.84 57.9 14.4 No No
10 empty 2.4 66.1 15 No No
2HIZ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 70.1 41.2 Yes Yes
2 empty 2.05 58.2 21.6 No No
3 empty 1.89 66.8 19.3 No No
4 empty 2.06 55.1 14.4 No No
5 empty 2.09 62.7 15.2 No No
6 empty 2.14 64.8 15.3 No No
7 empty 2.13 58.7 16.6 No No
8 empty 2.01 65.5 13.2 No No
9 empty 1.92 60.5 12.5 No No
10 empty 2.52 65.1 13 No No
6BFX_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 71.1 55.1 Yes Yes
2 empty 2.56 68.3 22.5 No No
3 empty 2.15 67.5 15.8 No No
4 empty 2.14 58 12.8 No No
5 empty 2.22 62.2 14.9 No No
6 empty 2.2 63.7 12.5 No No
7 empty 2.39 61.5 13.3 No No
8 empty 2.11 63.2 12.8 No No
9 empty 2.31 66 12.4 No No
10 empty 2.2 61.1 13.3 No No
2WF0_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 68.6 45.7 Yes Yes
2 empty 2.28 69.7 25.4 No No
3 empty 2.14 76.4 17.4 No No
4 empty 2.19 59.6 19.3 No No
5 empty 2.42 63.7 15.2 No No
6 empty 2.02 60.3 12.7 No No
7 empty 2.2 62.8 15.8 No No
8 empty 2.09 64.5 12.6 No No
9 empty 2.39 73.1 9.3 No No
10 empty 2.01 59.2 13.8 No No
4TRW_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 70 52.1 Yes Yes
2 empty 2.31 68.4 17.5 No No
3 empty 2.12 66.3 20.9 No No
4 empty 2.21 63.6 18.8 No No
5 empty 2.39 65.5 18 No No
6 empty 1.91 60.4 19.9 No No
7 empty 2.63 67.2 10.8 No No
8 empty 2.13 65.2 18.8 No No
9 empty 2.31 72.9 11.1 No No
10 empty 2.16 61.4 11.5 No No
2Q11_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 73.4 37.8 Yes Yes
2 empty 1.98 64.5 35.9 No No
3 empty 2.18 68.7 16 No No
4 empty 2.42 68.1 21.4 No No
5 empty 2.48 66.8 20.5 No No
6 empty 2.07 56.2 15.2 No No
7 empty 1.99 68.2 9.3 No No
8 empty 1.79 69.4 11.7 No No
9 empty 2.25 64.5 10.2 No No
10 empty 1.96 57.3 12.8 No No
4J1C_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 71.9 40.9 Yes Yes
2 empty 2.03 67.8 22.2 No No
3 empty 2.25 68.2 15.8 No No
4 empty 2.35 61.5 17.8 No No
5 empty 2.34 56.5 19.5 No No
6 empty 2.23 57.4 17.7 No No
7 empty 2.46 72.9 14.4 No No
8 empty 2.05 63 13 No No
9 empty 2.13 60.1 17.9 No No
10 empty 1.94 70.7 10.3 No No
5HTZ_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 69.8 54.3 Yes Yes
2 empty 2.11 61.4 34.9 No No
3 empty 2.52 64.3 24.8 No No
4 empty 2.32 64.8 16.7 No No
5 empty 2.08 72.1 10.8 No No
6 empty 2.19 66 12.1 No No
7 empty 1.85 67.8 14.9 No No
8 empty 1.99 65.3 12.4 No No
9 empty 2.04 56.3 14.4 No No
10 empty 2.14 69.1 12.3 No No
4YBI_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 70.6 39.6 Yes Yes
2 bound 2.11 57.6 31 No No
3 empty 2.35 63.6 16.3 No No
4 empty 2.22 63 19.3 No No
5 empty 2.23 57 14.4 No No
6 empty 2.03 61.7 13.7 No No
7 empty 2.02 62.4 14.3 No No
8 empty 1.97 62.4 11.7 No No
9 empty 2.1 57.6 15 No No
10 empty 1.86 57.3 13.9 No No
5HE4_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 73.4 46.1 Yes Yes
2 empty 2.04 64.4 32.3 No No
3 empty 2.15 62 16.9 No No
4 empty 2.32 64.2 16.7 No No
5 empty 2.46 63.8 13.4 No No
6 empty 2.18 71 12.2 No No
7 empty 2.05 66.1 11.8 No No
8 empty 2.02 61.5 13.5 No No
9 empty 2.09 65 10.9 No No
10 empty 2.26 63.6 13.7 No No
4FSL_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 70.2 54.5 Yes Yes
2 empty 2.23 61.8 20.2 No No
3 empty 2.23 66.5 19.5 No No
4 empty 2.38 69.7 12.7 No No
5 empty 2.15 57.6 16.9 No No
6 empty 1.87 67.1 18.2 No No
7 empty 2.15 71.2 11.7 No No
8 empty 2.23 60.3 15.2 No No
9 empty 2.11 68.7 15.9 No No
10 empty 2.05 70.5 12.4 No No
4B00_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 67.4 42.3 Yes Yes
2 empty 1.95 68.9 18.2 No No
3 empty 2.17 60.6 13.5 No No
4 empty 2.2 59.8 21.1 No No
5 empty 1.85 57.9 13.8 No No
6 empty 2.09 59.7 14.6 No No
7 empty 1.96 62.9 10.6 No No
8 empty 1.94 61.8 13 No No
9 empty 2.35 69.6 10.4 No No
10 empty 2.05 57.4 13.4 No No
6EJ2_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 72.4 43 Yes Yes
2 empty 2.18 73.1 24.4 No No
3 empty 2.26 68.1 16.6 No No
4 empty 2.28 58.4 21.9 No No
5 empty 2.44 60.3 25.4 No No
6 empty 2.24 58.9 18 No No
7 empty 2.36 68.7 13.8 No No
8 empty 2.23 58.8 13.9 No No
9 empty 1.81 63.8 15 No No
10 empty 2.49 66.8 13.8 No No
3RTM_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 68 30.6 Yes Yes
2 empty 1.87 71.8 16.1 No No
3 empty 2.25 62.4 16.3 No No
4 empty 2.15 62.5 20.5 No No
5 empty 1.91 56.9 18.2 No No
6 empty 1.93 55.6 11.3 No No
7 empty 2.35 62.3 12.9 No No
8 empty 1.99 59.4 12.2 No No
9 empty 2.02 53 17.3 No No
10 empty 2.43 66.6 11 No No
2QMF_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 71.6 48.4 Yes Yes
2 empty 2.54 66.4 23.5 No No
3 empty 2.11 62.2 21.4 No No
4 empty 1.92 64.5 22 No No
5 empty 2.14 61.8 20.4 No No
6 empty 2.14 72.9 12.7 No No
7 empty 2.11 65.6 12.8 No No
8 empty 2.01 69.9 12.1 No No
9 empty 1.89 58.1 15.3 No No
10 empty 2.19 67 19.2 No No
4TRZ_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 73.4 45.6 Yes Yes
2 empty 1.85 71.2 31.1 No No
3 empty 2.35 63.1 19.9 No No
4 empty 2.43 73.5 24.3 No No
5 empty 2.21 64.2 17.8 No No
6 empty 2.25 62.1 14.2 No No
7 empty 2.08 65.4 10.6 No No
8 empty 2.51 62.5 21.7 No No
9 empty 2.09 64.2 17.4 No No
10 empty 2.67 63.4 17.9 No No
2OHL_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 67.8 33.2 Yes Yes
2 empty 1.97 78.4 26 No No
3 empty 2.3 66.1 16.2 No No
4 empty 2.21 61 24.1 No No
5 empty 2.51 64.1 17.4 No No
6 empty 2.07 62.3 19.7 No No
7 empty 2.13 51.1 14.6 No No
8 empty 2.15 62.8 17.2 No No
9 empty 2.57 72.4 16.3 No No
10 empty 2.13 59.6 15.7 No No
4KE0_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.31 69.4 39.2 Yes Yes
2 empty 2.22 64.7 24.9 No No
3 empty 2.14 54.9 22.1 No No
4 empty 2.19 64.4 14.9 No No
5 empty 2 59.1 14.4 No No
6 empty 2.08 55.1 19.1 No No
7 empty 2.06 62.7 14.2 No No
8 empty 2.11 66.2 14.3 No No
9 empty 2.21 62.9 12.6 No No
10 empty 2.2 63.9 11.9 No No
3CID_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.32 66.4 53.8 Yes Yes
2 empty 2.12 62.8 21.1 No No
3 empty 2.23 61.1 12.4 No No
4 empty 2.37 58.1 18 No No
5 empty 1.94 65.8 12.2 No No
6 empty 1.97 68.6 11.3 No No
7 empty 1.97 60.5 16.7 No No
8 empty 2.45 69 12.1 No No
9 empty 2.2 57.2 11.6 No No
10 empty 1.84 52.2 12.7 No No
3LPI_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 66.8 47.5 Yes Yes
2 empty 2.17 62.5 21 No No
3 empty 2.16 62 13.6 No No
4 empty 2.08 62.7 13.4 No No
5 empty 2.29 56.8 14.7 No No
6 empty 2.11 63.2 11.2 No No
7 empty 1.98 63.3 13.4 No No
8 empty 2.09 56.7 12.1 No No
9 empty 2.4 66.4 12.5 No No
10 empty 2 52.6 14.7 No No
2VKM_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 70 54.2 Yes Yes
2 empty 2.45 65.1 24.5 No No
3 empty 2.13 64.3 19.9 No No
4 empty 2.56 57 16.5 No No
5 empty 2.06 55.2 13.5 No No
6 empty 2.23 61.9 17.6 No No
7 empty 2.14 70.9 11.8 No No
8 empty 1.98 67.1 13.4 No No
9 empty 2.08 67.3 12.4 No No
10 empty 1.94 62.2 10.8 No No
4J1H_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 69.2 46.7 Yes Yes
2 empty 2.34 67.2 16.4 No No
3 empty 2.2 58.7 19.1 No No
4 empty 2.28 63.8 14.7 No No
5 empty 2.4 74.1 10.5 No No
6 empty 2.47 57.7 21.2 No No
7 empty 2.23 64.3 14.6 No No
8 empty 1.89 67 12.2 No No
9 empty 2.52 70.2 15.8 No No
10 empty 2.28 66.2 10.9 No No
4I0I_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 70.5 51.9 Yes Yes
2 empty 2.61 63.2 21 No No
3 empty 2.17 63.1 21.7 No No
4 empty 2.36 67.8 15.6 No No
5 empty 2.16 68.1 16.1 No No
6 empty 2.34 60.8 16.7 No No
7 empty 2.11 64.3 16.8 No No
8 empty 2.41 65 11.3 No No
9 empty 2.46 70.6 12.7 No No
10 empty 1.95 65.9 10 No No
5ENM_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 74 28.6 Yes Yes
2 empty 2.04 67.2 28.1 No No
3 empty 2.39 69.8 15.4 No No
4 empty 1.86 63.7 21 No No
5 empty 1.98 61.5 16.3 No No
6 empty 2.04 67.4 16.3 No No
7 empty 2.15 63.8 11.2 No No
8 empty 2.5 69.4 10.5 No No
9 empty 2.16 64.5 10.5 No No
10 empty 2.46 73.7 10.8 No No
3IVI_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 70.8 54.8 Yes Yes
2 empty 2.05 63.9 17.2 No No
3 empty 2.26 62.9 13.2 No No
4 empty 2.29 66.1 15.3 No No
5 empty 2.51 67.7 13.7 No No
6 empty 2.06 69.2 12.7 No No
7 empty 2.21 66.5 11.9 No No
8 empty 2.17 64.1 11.6 No No
9 bound 2.32 66.4 12.8 No No
10 empty 2.48 70.1 12.8 No No
4DH6_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.31 71.2 47 Yes Yes
2 empty 2.14 61.1 25.6 No No
3 empty 2.44 68.1 17.5 No No
4 empty 2.36 70.3 11.9 No No
5 empty 2.06 60.7 15.1 No No
6 empty 2.27 63 14.1 No No
7 empty 2.31 67.1 13.5 No No
8 empty 2.12 70.3 7.3 No No
9 empty 2.34 57.6 17.9 No No
10 empty 2.38 74.7 13.9 No No
4J0T_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 72.1 39.7 Yes Yes
2 empty 2.25 68.6 30.7 No No
3 empty 2.31 66.3 15.6 No No
4 empty 2.1 57.5 15.7 No No
5 empty 2.37 73.9 15.1 No No
6 empty 2.4 63.4 21.4 No No
7 empty 2.03 54.9 16.2 No No
8 empty 1.86 62.1 12 No No
9 bound 2.24 68.5 16.7 No No
10 empty 2.01 66.6 10.4 No No
5HDV_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 75.7 28.6 Yes Yes
2 empty 2.16 58.2 29.4 No No
3 empty 2.18 59.1 27.3 No No
4 empty 2.09 60.1 18.2 No No
5 empty 2.26 61.3 21.5 No No
6 empty 2.06 62.8 12 No No
7 empty 1.95 67.6 11.4 No No
8 empty 1.96 62 12 No No
9 empty 2.45 63 12.6 No No
10 empty 1.89 60.9 15.5 No No
2VNN_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.35 73.5 47.5 Yes Yes
2 empty 2.3 72.3 24.5 No No
3 empty 2.27 61.3 20.3 No No
4 empty 2.24 63.4 15.2 No No
5 empty 1.93 55.9 12.7 No No
6 empty 2.07 63.6 11 No No
7 empty 2.3 60.8 12.1 No No
8 empty 2 60.2 13.9 No No
9 empty 1.6 70.8 10.2 No No
10 empty 2.46 71.3 9.9 No No
1FKN_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 71.4 55.3 Yes Yes
2 empty 2.16 63.3 17.6 No No
3 empty 2.4 53.7 15.2 No No
4 empty 2.24 64.4 13.4 No No
5 empty 2.35 60.6 13.8 No No
6 empty 1.84 69 14.9 No No
7 empty 2.18 73.1 12.3 No No
8 empty 2 62 18.8 No No
9 empty 2.02 64.3 13.5 No No
10 empty 2.52 65.7 11.8 No No
3LPK_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.36 69.9 47.9 Yes Yes
2 empty 1.92 59.7 19.7 No No
3 empty 2.11 61.8 21 No No
4 empty 2.28 61.1 13.5 No No
5 empty 2.06 60.4 13.1 No No
6 empty 2.17 56.3 14.8 No No
7 empty 2.06 67.5 11.8 No No
8 empty 2.05 57.2 13.1 No No
9 empty 1.98 64.1 11.3 No No
10 empty 2.55 66.8 12.5 No No
5HTZ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 73.9 38.6 Yes Yes
2 empty 1.91 64.3 32.4 No No
3 empty 2.23 66.6 18.1 No No
4 empty 2.33 63.9 14.7 No No
5 empty 2.08 68.5 15.2 No No
6 empty 1.97 68.7 14.7 No No
7 empty 2.11 72.8 13.2 No No
8 empty 2.12 61.2 16.2 No No
9 empty 2.03 65.6 12.2 No No
10 empty 2.15 60.5 11.5 No No
2P8H_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.26 71.9 53.5 Yes Yes
2 empty 2.06 61.8 24.1 No No
3 empty 2.27 65.3 18.7 No No
4 empty 2.38 71.1 16.4 No No
5 empty 2.25 52.1 14.1 No No
6 empty 2.05 68.2 13.1 No No
7 empty 2.21 62 12.9 No No
8 empty 2.57 68.4 13.6 No No
9 empty 1.91 59 13.5 No No
10 empty 1.94 60.7 14.1 No No
4FSE_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 68.6 54.4 Yes Yes
2 empty 2.24 60.4 23 No No
3 empty 2.36 65 14.4 No No
4 empty 2.26 66 17.3 No No
5 empty 2.15 60.4 19.2 No No
6 empty 2.23 57.7 15.6 No No
7 empty 2.09 70.3 11.7 No No
8 empty 2.06 65.7 13 No No
9 empty 2.43 66 19.3 No No
10 empty 2.01 69.4 12.5 No No
1XN2_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 75.8 37.3 Yes Yes
2 empty 2.07 63.4 35 No No
3 empty 2.5 65.5 23.7 No No
4 empty 2.37 63.7 20 No No
5 empty 2.07 55.4 15.4 No No
6 empty 2.39 62 14.2 No No
7 empty 2.3 64.6 9.6 No No
8 empty 2.16 70.8 11.7 No No
9 empty 2.15 64.3 13.1 No No
10 empty 2.09 65.5 16.4 No No
4DJW_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 68.1 38.9 Yes Yes
2 empty 2.26 58.6 34.4 No No
3 empty 2.45 62.6 17.3 No No
4 empty 2.12 61.9 22.3 No No
5 empty 2.18 59.4 14.2 No No
6 empty 2.07 66.9 11.6 No No
7 empty 1.94 62.9 10.9 No No
8 empty 1.92 62.1 16.4 No No
9 empty 1.97 57.6 12.5 No No
10 empty 1.88 57.2 13.5 No No
6DHC_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.37 68.6 47.9 Yes Yes
2 bound 2.08 70.4 15.4 No No
3 empty 2.02 58.3 18.6 No No
4 empty 2.23 65.2 14.6 No No
5 empty 2.09 65.3 14 No No
6 bound 2.32 62.2 14.9 No No
7 empty 1.84 66.3 11.5 No No
8 empty 2.1 63 15 No No
9 bound 2.01 59.6 11.4 No No
10 empty 2.04 63 11.9 No No
3RTN_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 70.4 52.7 Yes Yes
2 empty 2.56 66 30.2 No No
3 empty 2.29 64.1 21.2 No No
4 empty 2.31 69.2 14.6 No No
5 empty 2.23 61.9 12.8 No No
6 empty 1.98 64.4 18.8 No No
7 empty 1.85 64.6 11.7 No No
8 empty 2.13 62.4 11.3 No No
9 empty 2.48 71.3 13.9 No No
10 empty 2.18 59 14.6 No No
3KYR_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 68.6 54.3 Yes Yes
2 empty 2.07 61.1 20.2 No No
3 empty 1.97 65.2 23.1 No No
4 empty 2.22 66.5 14.6 No No
5 empty 2.25 67.6 16.6 No No
6 empty 2.25 67.4 13.5 No No
7 empty 2.35 66.7 18.3 No No
8 empty 2.21 63 15.5 No No
9 empty 2.32 58.7 14.9 No No
10 empty 1.75 100 0 Yes No
4LXM_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 71.8 53.2 Yes Yes
2 empty 2.25 62.9 19.7 No No
3 empty 2.62 60.1 26.3 No No
4 empty 2.42 66.1 17.3 No No
5 empty 2.16 67.1 13.3 No No
6 empty 2.12 68.1 13.7 No No
7 empty 1.78 67.1 12.4 No No
8 empty 2.51 66.9 10 No No
9 empty 2.61 69.3 10.3 No No
10 empty 2.13 60.2 11.3 No No
3INE_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 70.5 27.9 Yes Yes
2 empty 2.11 72.1 30.2 No No
3 empty 2.11 64.3 21.8 No No
4 empty 2.44 67 23.6 No No
5 empty 2.65 61 26.9 No No
6 empty 2.28 61.7 19 No No
7 empty 1.94 61.8 18.5 No No
8 empty 2.23 68.8 19.4 No No
9 empty 2.09 65.6 15.5 No No
10 empty 2.19 62.2 15.9 No No
3N4L_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 71.1 54.4 Yes Yes
2 empty 2.17 62 18.2 No No
3 empty 2.19 66.3 13.8 No No
4 empty 2.27 59.2 15.5 No No
5 empty 2.16 68.4 13.8 No No
6 empty 2.05 63.7 14.5 No No
7 empty 2.16 69.1 19.7 No No
8 empty 2.64 62.1 15 No No
9 empty 2.05 66.8 9.6 No No
10 empty 1.99 67.3 10.5 No No
4I0H_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 71.7 55.8 Yes Yes
2 empty 2.2 58.2 21.1 No No
3 empty 2.47 65.8 15.8 No No
4 empty 2.35 65.9 16.8 No No
5 empty 2.24 68.1 18.8 No No
6 empty 2.17 62.7 15.7 No No
7 empty 2.11 60.8 17.2 No No
8 empty 2.23 69.1 14.8 No No
9 empty 2.22 68.8 15.3 No No
10 empty 2.07 67.3 14.3 No No
4IVT_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 71 51.3 Yes Yes
2 bound 2.36 67.6 26.4 No No
3 empty 2.15 61.6 21.3 No No
4 empty 2.29 66.5 17.8 No No
5 empty 2.42 67.8 11.8 No No
6 empty 2.36 65 13.1 No No
7 empty 2 68 13.1 No No
8 empty 2.23 58.3 17.1 No No
9 empty 2.19 66.5 12 No No
10 empty 2.49 65.4 15.9 No No
6BFE_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 72.7 55 Yes Yes
2 empty 2.56 68.2 25.7 No No
3 empty 2.14 67.4 19.5 No No
4 empty 1.88 68 16.2 No No
5 empty 2.11 74 12.8 No No
6 empty 2.19 61.8 20.5 No No
7 empty 2.15 68.3 11 No No
8 empty 2.06 60.4 13.8 No No
9 empty 2.13 60.8 15.9 No No
10 empty 2.13 67.5 13.8 No No
4H3J_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 66.7 53 Yes Yes
2 empty 2.14 61 21.2 No No
3 empty 2.3 62.8 13.2 No No
4 empty 2.11 67.3 11.7 No No
5 empty 1.94 63.4 13.6 No No
6 empty 2.17 66.9 9.8 No No
7 empty 1.85 61.7 13.4 No No
8 empty 2.02 54.7 11.3 No No
9 empty 2.38 50.7 12.2 No No
10 empty 1.9 66.7 11.3 No No
5EZX_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 69 55.6 Yes Yes
2 empty 2.31 62.8 35.2 No No
3 empty 2.34 64.8 16.7 No No
4 empty 2.47 60.6 19.2 No No
5 empty 2.16 59.3 16.9 No No
6 empty 1.89 65.3 12 No No
7 bound 2.21 63.2 20.2 No No
8 empty 2 61.9 13.6 No No
9 empty 2.19 64.3 11.2 No No
10 empty 2.19 58.5 14.3 No No
3TPP_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 69.9 38.7 Yes Yes
2 empty 2.15 63.4 25.6 No No
3 empty 2.1 58.9 22 No No
4 empty 2.17 59.6 18.4 No No
5 empty 2.17 63.6 14.4 No No
6 bound 2.07 56 19 No No
7 empty 2.1 57.1 14.7 No No
8 empty 2.03 63.1 13 No No
9 bound 2.02 61.4 14.2 No No
10 empty 1.85 56.1 12.4 No No
2QMD_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 71.2 54.3 Yes Yes
2 empty 2.44 67.2 25.4 No No
3 empty 2.08 63 18.8 No No
4 empty 2 62.3 20.5 No No
5 empty 2.13 62 21.4 No No
6 empty 2.17 73.9 12.5 No No
7 empty 2.03 69.3 10.7 No No
8 empty 2.01 71.9 10.3 No No
9 empty 2.21 55.2 12.7 No No
10 empty 2.06 56.4 15.5 No No
4FRK_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.2 72.3 53.8 Yes Yes
2 empty 2.16 58.8 20.7 No No
3 empty 2.22 70.3 19.7 No No
4 empty 2.09 60 22.1 No No
5 empty 2.29 58.4 16.7 No No
6 empty 2.27 61.9 16.3 No No
7 empty 2.48 63.3 13.6 No No
8 empty 1.93 66 12.5 No No
9 empty 2.13 65.5 9.6 No No
10 empty 2.22 62.8 14.5 No No
3VF3_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 72.5 44.2 Yes Yes
2 empty 2.32 73.8 25.2 No No
3 empty 2.18 64.4 23.6 No No
4 empty 2.34 63 17 No No
5 empty 1.87 58.6 13.3 No No
6 empty 2.06 69.2 17 No No
7 empty 2.43 61.8 14.4 No No
8 empty 2.05 67 9.3 No No
9 empty 2.53 66.3 13.1 No No
10 empty 2.14 59 14.6 No No
5HDU_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 71.8 39.8 Yes Yes
2 empty 2.09 57.6 28 No No
3 empty 2.13 55.4 19.2 No No
4 empty 2.17 59.8 19.5 No No
5 empty 2.09 63 12.9 No No
6 empty 1.99 59.5 14.5 No No
7 empty 2.01 66.9 11.4 No No
8 empty 1.95 65.2 13.6 No No
9 empty 2.42 61.8 12.6 No No
10 empty 2.1 67.2 10.1 No No
1YM4_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 72.4 48.8 Yes Yes
2 empty 2.1 62.1 19.4 No No
3 empty 2.27 64.7 18.5 No No
4 empty 2.28 57.6 18.7 No No
5 empty 2.27 70.6 19.4 No No
6 empty 2.29 62.1 14.9 No No
7 empty 1.98 63.3 12 No No
8 empty 2.09 67.7 12.5 No No
9 empty 2.51 60.1 16.1 No No
10 empty 2.36 66.2 11.3 No No
2Q11_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 73 28.1 Yes Yes
2 empty 2.17 69.2 34.9 No No
3 empty 1.99 64.5 15.3 No No
4 empty 2.26 61.2 14.8 No No
5 empty 2.36 69.8 14 No No
6 empty 2.19 75.4 10.7 No No
7 empty 1.94 64.1 12.5 No No
8 empty 1.99 68.8 12.7 No No
9 empty 2.22 67.3 8.1 No No
10 empty 2.63 67.9 13.8 No No
4R95_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 72.4 44.8 Yes Yes
2 empty 2.03 64.8 30.7 No No
3 empty 1.99 76.3 21 No No
4 empty 2.23 64.3 15.3 No No
5 empty 2.26 63.4 13.1 No No
6 empty 2.17 68.2 15.1 No No
7 empty 2.44 63.8 15.7 No No
8 empty 2.12 70.5 11.5 No No
9 empty 1.99 67.8 10.8 No No
10 empty 2.01 63.6 16.1 No No
5HU0_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 66.3 52.1 Yes Yes
2 empty 2.27 61.3 17.1 No No
3 empty 2.14 63.1 14.3 No No
4 empty 2.21 65 12.6 No No
5 empty 2.05 59.5 13.7 No No
6 empty 1.95 60.4 12.9 No No
7 empty 1.96 65.5 11 No No
8 empty 1.94 56.2 13.9 No No
9 empty 2.11 53.7 11.1 No No
10 empty 1.71 64.7 10.4 No No
4FRJ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 74.7 48.2 Yes Yes
2 empty 2.35 68.8 12.4 No No
3 empty 2.14 57.8 21 No No
4 empty 1.96 63 21 No No
5 empty 2.08 69.7 10.8 No No
6 empty 2.01 60 18.8 No No
7 empty 2.32 60 18.8 No No
8 bound 2.05 65.8 17 No No
9 empty 2.04 62.1 13.3 No No
10 empty 2.38 71 9.4 No No
2ZJN_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 70.3 51.5 Yes Yes
2 empty 2.17 64.2 21.8 No No
3 empty 2.33 64 17.3 No No
4 empty 2.12 64.6 14.9 No No
5 empty 2.45 66.5 15 No No
6 empty 2.53 61.8 16.4 No No
7 empty 2.23 67.2 12.5 No No
8 empty 2.21 69.8 7.7 No No
9 empty 2.45 69.3 12.2 No No
10 empty 2.67 67.1 12.3 No No
3HW1_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 68.6 53.5 Yes Yes
2 empty 2.31 63.9 20.2 No No
3 empty 2.16 60 18.6 No No
4 empty 2.01 67 13.4 No No
5 empty 2.36 54.5 23.1 No No
6 empty 2.17 64.2 10.9 No No
7 empty 2.28 68 12.4 No No
8 empty 2.27 64.7 13.1 No No
9 empty 1.93 65.7 12.6 No No
10 empty 2.16 66.9 14 No No
3K5G_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 69.2 48.1 Yes Yes
2 empty 1.97 69.1 32.4 No No
3 empty 2.01 56.1 20.2 No No
4 empty 2.13 74 15 No No
5 empty 2.29 63.5 14.6 No No
6 empty 2.2 67.1 13.5 No No
7 empty 2.45 60.3 15 No No
8 empty 2.19 68.9 14.6 No No
9 empty 2.43 72.2 10.8 No No
10 empty 2.07 67.5 12.9 No No
2ZJI_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 69.7 48.7 Yes Yes
2 empty 2.23 67.6 25 No No
3 empty 2.27 61.8 20.6 No No
4 empty 2.32 66 12.4 No No
5 empty 2.38 62.6 15.3 No No
6 empty 2.07 61.3 14.9 No No
7 empty 1.99 57.9 15.1 No No
8 empty 2.35 69.1 9.5 No No
9 empty 2.54 69.9 13.9 No No
10 empty 2.05 68.9 11.9 No No
6BFW_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 69.8 30.4 Yes Yes
2 bound 2.04 57 31.6 No No
3 empty 2.14 61.7 19.7 No No
4 empty 2.36 62.2 17.7 No No
5 empty 2.38 63.2 14.9 No No
6 empty 1.77 56.4 14.6 No No
7 empty 2.08 67.8 11.9 No No
8 empty 2.05 61.9 13.9 No No
9 empty 2.15 61.6 10.3 No No
10 empty 1.89 62.6 11.3 No No
3IN4_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 71 53.3 Yes Yes
2 empty 2.5 66.2 27.9 No No
3 empty 2.12 62.6 23.1 No No
4 empty 2.13 64.3 15.3 No No
5 empty 2.67 64.6 17.9 No No
6 empty 2.09 62.8 13.9 No No
7 empty 2.14 62.3 13.5 No No
8 empty 2.52 69.5 9.8 No No
9 empty 1.92 57.8 14.3 No No
10 empty 2.12 62.3 13 No No
4H1E_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 71.6 48.6 Yes Yes
2 empty 2.1 60.4 38.6 No No
3 empty 2.29 63.5 18.1 No No
4 empty 2.2 72.1 12.5 No No
5 empty 2.08 62.1 11.2 No No
6 empty 2.03 65.9 11.8 No No
7 empty 2.33 64.2 13 No No
8 empty 2.29 64 12.3 No No
9 empty 2.16 69.4 18.4 No No
10 empty 2.04 68.6 13.4 No No
2OHM_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 69.5 41.7 Yes Yes
2 empty 2.26 66 19 No No
3 empty 2.48 70.6 16.1 No No
4 empty 2.2 61.5 16.3 No No
5 empty 2.61 64.1 14.6 No No
6 empty 2.2 60 16.3 No No
7 empty 2.1 51.6 14.4 No No
8 empty 1.98 60.1 12.2 No No
9 empty 2.56 65 13.7 No No
10 empty 1.88 56.5 14.2 No No
4LXA_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 71.1 49.8 Yes Yes
2 empty 2.1 62.7 18.3 No No
3 empty 2.29 63.4 17.9 No No
4 empty 2.31 63 16.1 No No
5 empty 2.05 68.4 10.8 No No
6 empty 2.61 61.7 20.7 No No
7 empty 2.15 67.7 18.4 No No
8 empty 2 68.8 11.8 No No
9 empty 2.41 62.4 21.4 No No
10 empty 2.44 68.3 14.1 No No
2XFK_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.26 72 47.3 Yes Yes
2 empty 2.3 70.6 24 No No
3 empty 2.28 62 20 No No
4 empty 2.37 65.1 13.7 No No
5 empty 1.88 61 13.7 No No
6 empty 2.13 60.9 12.9 No No
7 empty 2.1 56.6 13.2 No No
8 empty 2.38 60.6 13.7 No No
9 empty 2.22 65 12 No No
10 empty 2.61 68.2 11.3 No No
3DM6_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.37 83.5 25.5 Yes Yes
2 bound 2.18 64.7 24.2 No No
3 empty 1.94 58.9 22.4 No No
4 empty 2.03 61.1 20.7 No No
5 empty 2.21 59.5 21.6 No No
6 empty 1.82 64.4 12.8 No No
7 empty 2.09 65.6 12.8 No No
8 empty 1.99 55.8 12 No No
9 empty 2.12 56.6 15.3 No No
10 empty 1.93 57.5 11.7 No No
5TOL_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 71.1 47.5 Yes Yes
2 empty 2.37 66 20.4 No No
3 empty 2.31 60.8 15.6 No No
4 empty 2.19 66.3 16.8 No No
5 empty 1.81 56.6 14.8 No No
6 empty 2.23 59.6 13 No No
7 empty 2.11 62.1 16.4 No No
8 empty 2.2 65.3 12.8 No No
9 empty 1.75 63.7 14.4 No No
10 empty 2.38 73.8 11.9 No No
3CIB_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 71.7 55.4 Yes Yes
2 empty 2.21 64.5 20.1 No No
3 empty 2.19 57.8 20.7 No No
4 empty 2.5 69.3 17.8 No No
5 empty 2.33 66 18.4 No No
6 empty 1.95 71.6 11.5 No No
7 empty 2.31 68.5 15.5 No No
8 empty 2.12 65 12.7 No No
9 empty 1.93 67.6 15.4 No No
10 empty 2.16 66.5 12.5 No No
4R8Y_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 73.1 47.8 Yes Yes
2 empty 2.02 63.9 30 No No
3 empty 2.23 65.6 14.4 No No
4 empty 2.19 71.6 11.8 No No
5 empty 2.02 67.4 11.5 No No
6 empty 2.01 65.1 16.9 No No
7 empty 2.17 63.6 15 No No
8 empty 2.04 64.1 13 No No
9 empty 1.85 70.6 10.4 No No
10 empty 2.16 62 13 No No
2VA6_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 67.3 38.9 Yes Yes
2 empty 2.18 70.2 28.1 No No
3 empty 2.34 65.1 16.6 No No
4 empty 2.09 60.2 18.4 No No
5 empty 2.04 63.6 14.6 No No
6 empty 1.86 52.7 14.5 No No
7 empty 2.19 66.3 13.3 No No
8 empty 2.56 63.3 13 No No
9 empty 2.14 60.4 12 No No
10 empty 2.31 60.8 14.5 No No
4B1D_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 66.8 44.4 Yes Yes
2 empty 2.02 75.1 29.3 No No
3 empty 2.16 69 16.7 No No
4 empty 2.22 60.3 19.4 No No
5 empty 2.24 68 13.7 No No
6 empty 2.14 60.7 13.6 No No
7 empty 2.11 59.7 12.3 No No
8 empty 2.32 63.4 11.1 No No
9 empty 2.61 68.8 9.9 No No
10 empty 2.06 68.1 10.5 No No
3TPJ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 68.6 52.8 Yes Yes
2 bound 2.1 66.2 25.8 No No
3 empty 2.28 65.1 18.1 No No
4 empty 1.88 59.3 20.6 No No
5 bound 2.04 66.5 13.7 No No
6 empty 2.04 71.5 9.2 No No
7 empty 2.04 63.2 11.3 No No
8 empty 2 57.4 13.8 No No
9 empty 2.62 68.8 13.1 No No
10 bound 2.51 57 13.7 No No
6BFX_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 72.6 37.7 Yes No
2 bound 2.13 58.2 33 No No
3 empty 2.39 63.5 17.2 No No
4 empty 2.17 60.4 20.3 No No
5 empty 1.9 56.5 16.3 No No
6 empty 1.91 60.8 16.6 No No
7 empty 2 68.1 11.7 No No
8 empty 2.06 64 12.2 No No
9 empty 2.53 69 12.5 No No
10 empty 2.41 72.4 12.7 No No
3LPJ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 70.5 54.4 Yes Yes
2 empty 2.18 60.5 21 No No
3 empty 2.12 67.1 18.1 No No
4 empty 2.48 69.9 16.2 No No
5 empty 2.27 63.7 16.4 No No
6 empty 2.07 69.8 11.6 No No
7 empty 2.14 63.3 12 No No
8 empty 2.17 68.4 11.8 No No
9 empty 1.99 65.1 12.3 No No
10 empty 2.05 69.9 11.4 No No
2VKM_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 71.1 53.9 Yes Yes
2 empty 2.57 66.9 24.6 No No
3 empty 2.2 63.1 20.2 No No
4 empty 2.1 51.8 17 No No
5 empty 2.6 57.2 16.1 No No
6 empty 2.14 70.7 11.9 No No
7 empty 2.17 66 14.1 No No
8 empty 2.09 63.4 19.4 No No
9 empty 2.12 64.6 13.2 No No
10 empty 2.07 56.7 13.5 No No
2OHU_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 69.7 47.2 Yes Yes
2 empty 2.35 69.1 15.8 No No
3 empty 2.15 59.7 21.5 No No
4 empty 2.24 65.2 17.9 No No
5 empty 1.99 61.9 14.6 No No
6 empty 2.09 64.2 11.6 No No
7 empty 2.46 66.5 12.5 No No
8 empty 2.45 70.7 16.8 No No
9 empty 2.03 66.8 9.6 No No
10 bound 2.32 64.6 14.5 No No
4TRZ_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 72 55 Yes Yes
2 empty 2.17 59.6 22.7 No No
3 empty 2.26 60.7 19.6 No No
4 empty 2.12 64 13.6 No No
5 empty 2.2 68.7 12.2 No No
6 empty 2.19 57.5 20.9 No No
7 empty 2.02 62.2 17.1 No No
8 empty 2.11 62.8 13.1 No No
9 empty 2.09 64 12.9 No No
10 empty 2.49 69.2 8.9 No No
4I0G_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 70.5 47.6 Yes Yes
2 empty 2.16 67.1 30.2 No No
3 empty 2.22 66.4 18.1 No No
4 empty 2.1 61 20 No No
5 empty 2.24 69.7 13.9 No No
6 empty 2.17 62.7 12 No No
7 empty 2.07 65 13.1 No No
8 empty 2.08 59.7 15.1 No No
9 empty 2.12 69.6 10.6 No No
10 empty 2.11 68.3 10.4 No No
2ZJM_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 70.5 54.3 Yes Yes
2 empty 2.15 60.9 20.7 No No
3 empty 2.29 67.7 14.4 No No
4 empty 2.06 58.2 18.1 No No
5 empty 2.2 66.4 12.7 No No
6 empty 2.75 67.5 16.2 No No
7 empty 2.08 66.9 8.9 No No
8 empty 1.82 59.6 12.7 No No
9 empty 2.51 69.5 11.3 No No
10 empty 2.4 63.8 12.7 No No
4L7J_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 68.2 54.7 Yes Yes
2 empty 2.33 67.2 28.6 No No
3 empty 2.24 60.6 22.9 No No
4 empty 2.13 62.7 21.8 No No
5 empty 2.18 68.6 15.9 No No
6 empty 2.33 66 17.7 No No
7 empty 2 64.9 11.4 No No
8 empty 2.49 72.3 11 No No
9 empty 2.02 61.9 14.3 No No
10 empty 1.95 99.4 0 Yes No
2VA5_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 72.2 48.2 Yes Yes
2 empty 2.38 53.9 20.7 No No
3 empty 2.25 64.6 21.3 No No
4 empty 2.64 66.5 18 No No
5 empty 2.4 67.9 14.7 No No
6 empty 2.22 65 19.6 No No
7 empty 2.06 60.1 16.7 No No
8 empty 2.15 57.9 13.5 No No
9 empty 2.49 62.1 13.4 No No
10 empty 2.16 66.9 14 No No
4D8C_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 70.2 54.9 Yes Yes
2 empty 2.31 61.2 19.8 No No
3 empty 2.34 63.1 17.3 No No
4 empty 2.21 62.7 16.9 No No
5 empty 2.19 63.8 16.9 No No
6 empty 2.12 69.4 13.8 No No
7 empty 2.35 69.3 10.9 No No
8 empty 2.53 70.2 11.2 No No
9 empty 2.57 68.6 12.6 No No
10 empty 2.55 61.5 10.3 No No
2XFI_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.31 71.9 43.9 Yes Yes
2 empty 2.42 69.7 17.8 No No
3 empty 2.22 60.8 19.6 No No
4 empty 2.02 59.9 13.4 No No
5 empty 2.48 66.9 13.2 No No
6 empty 2.1 62.6 13.5 No No
7 empty 2.23 59 14.2 No No
8 empty 1.97 72.6 13.4 No No
9 empty 2.3 72.8 8.2 No No
10 empty 2.24 59.9 14.7 No No
3UDY_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 67.4 60.2 Yes Yes
2 empty 2.09 67.9 25 No No
3 empty 1.95 61.8 23.2 No No
4 empty 2.15 59.5 22.1 No No
5 empty 2.17 62.6 18.2 No No
6 empty 2.21 70.3 14.7 No No
7 empty 2.06 73.9 11.1 No No
8 empty 2.11 66.8 13.3 No No
9 empty 2.5 57.3 19.7 No No
10 empty 2.08 64.7 11.9 No No
5V0N_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 70.7 54.9 Yes Yes
2 empty 2.11 58.9 21.3 No No
3 bound 2.29 75.6 13.8 No No
4 empty 2.24 63.7 14.5 No No
5 empty 2.14 65.8 13.2 No No
6 empty 2.41 63.8 11.5 No No
7 empty 2.14 68.5 10.6 No No
8 empty 2.32 70 12.7 No No
9 empty 2.4 57.3 18.3 No No
10 empty 2.43 64.7 13.9 No No
4DJX_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 72.4 54.2 Yes Yes
2 empty 2.43 68.6 25.9 No No
3 empty 2.18 66.9 19.9 No No
4 empty 2.21 62.6 16.6 No No
5 empty 2.19 65.7 14.8 No No
6 empty 2.15 72.2 10.7 No No
7 empty 2.15 63.9 16 No No
8 empty 2.27 59.3 16.4 No No
9 empty 1.93 65.7 15.4 No No
10 empty 2.05 67.6 12.3 No No
2OHR_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 69.4 56.2 Yes Yes
2 empty 2.16 59.3 22 No No
3 empty 1.99 59.7 23.3 No No
4 empty 2.3 68 18.7 No No
5 empty 2.21 67.5 11.8 No No
6 empty 2.18 62.6 16.7 No No
7 bound 2.33 66 16.4 No No
8 empty 2.28 63.2 12.9 No No
9 empty 2.46 64.3 13.2 No No
10 empty 2.47 67.6 12.9 No No
3INH_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 71.6 46.7 Yes Yes
2 empty 2.6 66 28.9 No No
3 empty 2.28 65.1 22.3 No No
4 empty 2.17 62.4 19.2 No No
5 empty 2.48 66.1 21.8 No No
6 empty 1.98 61.7 15.8 No No
7 empty 2.11 61 15.8 No No
8 empty 2.26 60 16.5 No No
9 empty 2.48 71.7 9.2 No No
10 empty 1.83 60.3 13 No No
3IVI_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 69.8 53.5 Yes Yes
2 empty 2.18 65.8 23.5 No No
3 empty 2.05 59 20.5 No No
4 empty 2.23 61.8 16.1 No No
5 empty 2.3 62.2 14.1 No No
6 empty 1.78 72.9 10.6 No No
7 empty 2.16 65.9 14.4 No No
8 empty 2.37 62.1 12.9 No No
9 empty 2.21 68.9 11.5 No No
10 empty 2.05 65.8 11.9 No No
3QI1_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 75.5 33.8 Yes Yes
2 empty 1.94 70.9 21.9 No No
3 empty 2.31 66.6 15.7 No No
4 empty 2.13 61.3 20.3 No No
5 empty 2.17 58.1 12.6 No No
6 empty 2.12 67.8 9.8 No No
7 empty 2.02 68.7 12.6 No No
8 empty 2.21 52.1 13.5 No No
9 empty 2.19 62.6 10.5 No No
10 empty 2.12 61.2 10.2 No No
4ZSP_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 72 39.6 Yes Yes
2 bound 2.02 56.3 32.1 No No
3 empty 2.15 61.8 19.9 No No
4 empty 2.38 70.8 18.4 No No
5 empty 2.22 62.8 13.4 No No
6 empty 2.2 55.4 14.4 No No
7 empty 2.02 62.8 13.5 No No
8 empty 1.95 62.9 11.2 No No
9 empty 2.07 53.7 11.2 No No
10 empty 1.86 53.2 13.5 No No
4LC7_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 69.5 47.4 Yes Yes
2 empty 2.08 65.8 25.2 No No
3 empty 2.33 60.1 32.2 No No
4 empty 2.07 65.5 15.6 No No
5 empty 1.94 62.5 19.7 No No
6 empty 2.21 71.9 10.9 No No
7 empty 2.21 71.4 9.7 No No
8 empty 2.2 64.4 13.7 No No
9 empty 2.14 64 13.4 No No
10 empty 1.93 61 11.8 No No
4D8C_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 69.2 55 Yes Yes
2 empty 2.12 65.1 24.2 No No
3 empty 2.3 63.1 25.6 No No
4 empty 2.16 56.9 19 No No
5 empty 2.12 72.9 16 No No
6 empty 2.21 62.8 12.8 No No
7 empty 2.45 64.7 15.4 No No
8 empty 2.34 63.3 14.3 No No
9 empty 2.4 68.4 10.2 No No
10 empty 2.09 65.5 13.3 No No
3CID_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 66 54.7 Yes No
2 empty 2.2 61.3 20.1 No No
3 empty 1.95 56 17.8 No No
4 empty 2.28 65.7 12.4 No No
5 empty 1.92 62.6 12.2 No No
6 empty 2.07 68.9 11.1 No No
7 empty 2.05 67.4 9.9 No No
8 empty 2.12 55.3 11.1 No No
9 empty 2.32 70.5 9.9 No No
10 empty 2.09 58.9 14.1 No No
4X2L_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 69.7 50 Yes Yes
2 empty 1.88 61.9 17.5 No No
3 empty 2.25 66.3 15.7 No No
4 bound 2.04 65.1 13.2 No No
5 empty 2.51 63.8 12.2 No No
6 bound 2.17 67.1 15.4 No No
7 empty 2.04 65.8 12.1 No No
8 empty 2.33 65.7 11.6 No No
9 empty 2.26 62.1 12.4 No No
10 empty 2.29 58.8 15.8 No No
2QP8_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 63.2 42.7 Yes No
2 bound 2.08 77.1 19.6 No No
3 empty 2.17 62.7 18.3 No No
4 empty 1.95 55.1 16.7 No No
5 empty 2.24 61.8 15.2 No No
6 empty 1.92 61.2 13.2 No No
7 empty 1.95 63.4 10.6 No No
8 empty 2.1 65.2 11.6 No No
9 empty 2.18 64 13.6 No No
10 empty 2.13 58 11.2 No No
2VJ7_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.31 70.3 54.3 Yes Yes
2 empty 2.17 69.7 25.5 No No
3 empty 2.38 60.1 18.3 No No
4 empty 2.19 61.3 12.7 No No
5 empty 2.34 65.1 21.9 No No
6 empty 2.31 61.1 20.6 No No
7 empty 2.23 62.4 11.5 No No
8 empty 2.02 60.1 14.1 No No
9 empty 2.66 67.7 11.1 No No
10 empty 2.03 60.5 12.3 No No
5HU0_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 70.4 48.2 Yes Yes
2 empty 2.55 64.6 24.6 No No
3 empty 2.29 63.5 21.6 No No
4 empty 1.97 61.6 23.3 No No
5 empty 2.07 60.2 16.7 No No
6 empty 2.18 63.2 20.3 No No
7 empty 2.12 73 12 No No
8 empty 1.96 70.7 13.6 No No
9 empty 2.04 66 9.9 No No
10 empty 2.05 60.5 13.7 No No
3CKP_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 71 42.7 Yes Yes
2 empty 1.97 64.1 37.7 No No
3 empty 2.06 69.8 17.2 No No
4 empty 2.1 63.5 16.9 No No
5 empty 2.29 69.7 14.6 No No
6 empty 2.24 60.2 17.4 No No
7 empty 2.35 61.8 16.2 No No
8 empty 2.19 61.3 15.2 No No
9 empty 2.01 67.2 8.6 No No
10 empty 2.32 64.6 15.2 No No
4LXA_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 70.9 50.9 Yes Yes
2 empty 2.28 62.5 19.8 No No
3 bound 2.39 65.1 17.6 No No
4 empty 2.14 67.1 14.5 No No
5 empty 2.62 71.3 11.9 No No
6 empty 2.47 59.8 13.8 No No
7 empty 2.02 69.4 13.6 No No
8 empty 2.58 68.9 11.2 No No
9 empty 1.81 67.3 10.8 No No
10 empty 2.42 65.9 10.2 No No
3KMY_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 70.7 52.8 Yes Yes
2 empty 2.5 63.8 19 No No
3 empty 1.94 62.3 20.2 No No
4 empty 2.22 67.6 20.8 No No
5 empty 2.19 62.7 19.1 No No
6 empty 2.15 72.6 12.5 No No
7 empty 2.02 66.5 11.9 No No
8 empty 1.88 61.4 14.6 No No
9 empty 2.28 53 13.1 No No
10 empty 2.6 65.7 12.4 No No
2QMG_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.26 71.5 48.9 Yes Yes
2 empty 2.51 66.3 23.3 No No
3 empty 2.11 64.4 21 No No
4 empty 1.93 62.5 20.6 No No
5 empty 2.12 62.3 21.3 No No
6 empty 2.17 69.5 13.8 No No
7 empty 2.08 66.1 12.9 No No
8 empty 2.08 56.9 13.6 No No
9 empty 1.75 69.6 14.9 No No
10 empty 2.06 68 19.3 No No
4K9H_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 73.9 54.3 Yes Yes
2 empty 2.24 67.8 15.3 No No
3 empty 2.28 63.7 14.8 No No
4 empty 2.2 67.7 15.5 No No
5 empty 2.17 63.9 13 No No
6 empty 2.32 63.8 21.2 No No
7 empty 2.21 64.5 10.2 No No
8 empty 2.61 67.9 13 No No
9 empty 2.33 58 14.5 No No
10 empty 1.93 64.6 12.1 No No
1FKN_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 73.1 35.9 Yes Yes
2 empty 2.11 68.4 37.3 No No
3 empty 2.18 65.3 31.7 No No
4 empty 2.03 62 21.3 No No
5 empty 2.33 62.8 16.4 No No
6 empty 2.42 64.6 20.6 No No
7 empty 2.42 59.9 13 No No
8 empty 2.03 69.8 14 No No
9 empty 2.21 72.4 10.8 No No
10 empty 2.13 66.8 8.7 No No
1XN2_D Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 72.7 54.4 Yes Yes
2 empty 2.46 64.3 15.7 No No
3 empty 2.19 66.3 19.2 No No
4 empty 1.91 63.4 19.1 No No
5 empty 2.06 59.1 21.2 No No
6 empty 2.28 58.6 13.3 No No
7 empty 2.58 56.8 14.8 No No
8 empty 2.11 71.8 10.9 No No
9 empty 2.17 62.3 13.7 No No
10 empty 1.81 68.5 15.7 No No
4JP9_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 67.7 54 Yes Yes
2 empty 2.16 66.6 28.4 No No
3 empty 2.17 57.4 20.2 No No
4 empty 2.36 66.3 14.6 No No
5 empty 1.9 60.2 22.8 No No
6 empty 2.15 59.2 19.1 No No
7 empty 2.34 67 12 No No
8 empty 2.22 72.9 18.2 No No
9 empty 2.08 64.8 12.4 No No
10 empty 2.08 60.7 10.8 No No
5T1W_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 69.8 49.4 Yes Yes
2 empty 2.18 59.6 24 No No
3 empty 2.21 68.2 13.3 No No
4 empty 2.34 68.5 20.3 No No
5 bound 2.05 63 14.4 No No
6 empty 2.14 64.5 18.7 No No
7 bound 2.22 67.5 20.2 No No
8 empty 2.16 63.8 12.1 No No
9 empty 2.19 66.7 13.5 No No
10 empty 2.51 72.1 11.7 No No
3TPL_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 70.1 50.7 Yes Yes
2 empty 2.12 65 19.1 No No
3 empty 2.03 65.6 21.4 No No
4 empty 1.99 67.8 12.5 No No
5 empty 2.1 65.8 12.3 No No
6 empty 2.28 72.1 10.8 No No
7 empty 2.06 66.8 12.3 No No
8 empty 2.37 69 11.4 No No
9 empty 2.05 65.3 16.1 No No
10 empty 2.16 68.7 12.2 No No
5MXD_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 70.8 52.4 Yes Yes
2 empty 2.59 67.1 25.7 No No
3 empty 2.29 65.6 15.6 No No
4 empty 2.15 56.8 19.4 No No
5 empty 1.99 63.1 12.1 No No
6 empty 2.22 67 17 No No
7 empty 2.43 58.1 17.6 No No
8 empty 2.02 65.4 12.1 No No
9 empty 2.28 61.9 19.2 No No
10 empty 2.4 61.6 17.5 No No
3MSJ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 70.4 50.2 Yes Yes
2 empty 2.19 64.9 20.5 No No
3 empty 1.96 63.5 19.6 No No
4 empty 2.11 63.5 12.1 No No
5 empty 1.96 58.7 14.5 No No
6 bound 2.01 64.6 11.6 No No
7 empty 2.05 63.3 12.4 No No
8 empty 2.33 67.2 9.9 No No
9 empty 2.46 61.7 13.1 No No
10 bound 2.29 67.5 11.7 No No
1XN3_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 70.1 53.7 Yes Yes
2 empty 2.59 67 23.9 No No
3 empty 2.2 63.3 19.7 No No
4 empty 1.95 58.1 21.6 No No
5 empty 2.1 62.1 13.7 No No
6 empty 2.39 57.6 14.5 No No
7 empty 2.05 67 11.9 No No
8 empty 2.24 71.8 10.8 No No
9 empty 2.11 62.5 12.6 No No
10 empty 2.32 59.3 15.5 No No
4B78_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 72 53.7 Yes Yes
2 empty 2.31 67.7 17.6 No No
3 empty 2.55 64.4 20.1 No No
4 empty 2.29 68 15 No No
5 empty 2.1 58.2 11.4 No No
6 empty 2.15 60.9 12.9 No No
7 empty 2.19 60.7 15.4 No No
8 empty 1.75 64.5 11.5 No No
9 empty 2.05 68.8 9.9 No No
10 empty 2.35 59.7 12.4 No No
2WF1_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.33 71.6 46.1 Yes Yes
2 empty 2.39 69.6 29.2 No No
3 empty 2.27 59.5 17.9 No No
4 empty 1.98 79.3 17.7 No No
5 empty 2.3 63.7 20.7 No No
6 empty 1.9 60 13.8 No No
7 empty 2.11 62.5 13.2 No No
8 empty 2.17 63.8 13.4 No No
9 empty 2.4 60.8 13.8 No No
10 empty 2.39 73.8 8.7 No No
4R92_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 71.4 37.1 Yes Yes
2 empty 2.04 66.4 33.1 No No
3 empty 2.1 71.4 29.1 No No
4 empty 2.29 63.8 17.5 No No
5 empty 2.1 67.4 19.3 No No
6 empty 2.16 72.9 10.9 No No
7 empty 2.13 65.3 14.5 No No
8 empty 2.05 64.9 12.1 No No
9 empty 2.01 63.9 16.2 No No
10 empty 2.12 68.1 15.2 No No
3TPR_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 70.6 44.7 Yes Yes
2 empty 2.29 67.5 12.4 No No
3 empty 2.07 62.8 23 No No
4 empty 1.95 65.3 11 No No
5 empty 1.45 64.7 14.3 No No
6 empty 1.69 71.4 14.8 No No
7 empty 2.62 64.8 15 No No
8 empty 2.25 61.4 17.6 No No
9 empty 2.1 63.9 11.8 No No
10 empty 1.87 61 11.5 No No
3BUF_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 70.7 41.5 Yes Yes
2 empty 2.35 65.8 26.4 No No
3 empty 2.42 67.2 18.1 No No
4 empty 2.06 66.9 13.4 No No
5 empty 2.38 62.9 17.7 No No
6 empty 2.34 58.7 16 No No
7 empty 2.04 65.5 12.9 No No
8 empty 2.43 69.7 17.2 No No
9 empty 2.34 73.9 9.5 No No
10 empty 2.45 62.8 13.8 No No
4I10_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 68.7 63.5 Yes Yes
2 empty 2.37 73 23.5 No No
3 empty 2.16 59.1 17.1 No No
4 empty 1.93 61.6 20.5 No No
5 empty 2.08 67.4 13.5 No No
6 empty 2.07 63 16.4 No No
7 empty 2.09 62.3 12.7 No No
8 empty 2.31 66.2 12.9 No No
9 empty 2.28 64.7 15.5 No No
10 empty 2.02 57.9 15 No No
4I0J_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 70.6 45.6 Yes Yes
2 empty 2.01 65.8 30.4 No No
3 empty 2.27 71.6 13.6 No No
4 empty 2.32 62.1 20.5 No No
5 empty 2.31 65.2 12 No No
6 empty 2.07 68.4 15.7 No No
7 empty 2.52 67.4 17.6 No No
8 empty 2.2 66.2 14.2 No No
9 empty 1.91 59.2 10.9 No No
10 empty 2.22 59.8 14.6 No No
4I0I_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 70.3 54.7 Yes Yes
2 empty 2.02 58.4 19.6 No No
3 empty 2.38 62 17.7 No No
4 empty 1.78 72.3 12.3 No No
5 empty 2.09 67.8 15.9 No No
6 empty 2.31 65.3 14.3 No No
7 empty 2.25 65.6 14.1 No No
8 empty 2.36 62.5 12.6 No No
9 empty 2.2 63.5 11 No No
10 empty 2.08 65.5 9.3 No No
2FDP_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 70.5 51 Yes Yes
2 empty 2.19 62.2 15.3 No No
3 empty 2.42 64.3 15.2 No No
4 empty 2.37 64.3 16.8 No No
5 empty 2.25 68.1 11 No No
6 empty 2.33 68.4 15.3 No No
7 empty 2.21 69.2 14.2 No No
8 empty 2.17 67.8 10.5 No No
9 empty 2.57 66.1 11.5 No No
10 empty 2.64 71.1 8.9 No No
2WF3_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 71.1 52.3 Yes Yes
2 empty 2.27 72.5 25 No No
3 empty 2.37 59.9 19 No No
4 empty 2.29 64.1 20.1 No No
5 empty 2.19 62 13.8 No No
6 empty 2.32 59.4 15.8 No No
7 empty 2 63.5 10.3 No No
8 bound 1.64 72.2 10 No No
9 empty 2.53 74.7 7.8 No No
10 empty 2.02 58.3 14.1 No No
4DJU_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 71.4 28.7 Yes Yes
2 empty 2.23 60.4 27.8 No No
3 empty 2.36 59.5 20.6 No No
4 empty 2.09 62.3 21.8 No No
5 empty 1.78 59.8 21.7 No No
6 empty 2.19 59.2 14 No No
7 empty 2.15 56.4 14.8 No No
8 empty 2.07 62.1 13.7 No No
9 empty 1.93 67.2 11.3 No No
10 empty 2.09 58.3 14.1 No No
4DVF_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 71.6 38.7 Yes Yes
2 empty 2.38 64.8 30.2 No No
3 empty 2.24 61.8 26.1 No No
4 empty 2.11 61.8 20.8 No No
5 empty 2.29 67.5 14.9 No No
6 empty 2.31 63.3 14.4 No No
7 empty 2.24 67.6 13.8 No No
8 empty 2.1 67.4 12.4 No No
9 empty 2.23 60.2 13.1 No No
10 empty 1.97 61.2 14 No No
3R2F_D Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.25 71.2 53.2 Yes Yes
2 empty 2 72.6 11.9 No No
3 empty 2.39 68.5 15.4 No No
4 empty 2.57 54.2 15.9 No No
5 empty 2.26 65.9 15.6 No No
6 empty 2.12 60.2 17.6 No No
7 empty 2 63.5 14.3 No No
8 empty 2.04 64.5 17.6 No No
9 empty 2.1 71.7 11.5 No No
10 empty 2.07 71.4 8.4 No No
2QZL_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.31 71.6 53.9 Yes Yes
2 empty 2.07 61 25.1 No No
3 empty 2.34 64.8 20.4 No No
4 empty 2.34 67.7 13.5 No No
5 empty 2.54 69.8 15.2 No No
6 empty 2.4 61.1 18 No No
7 empty 2.75 58.9 22.1 No No
8 empty 2.02 67.7 10.7 No No
9 empty 2 58 12.4 No No
10 empty 2.14 61.6 13.1 No No
3UDR_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 68.8 46 Yes Yes
2 empty 2.07 64.9 28.6 No No
3 empty 2.1 55.9 21.6 No No
4 empty 2.12 65.3 16 No No
5 empty 2.04 56.3 18.9 No No
6 empty 1.95 63.8 12.9 No No
7 empty 1.92 66.6 10 No No
8 empty 2.09 52.1 12.2 No No
9 empty 2.01 65.4 11.6 No No
10 empty 2.44 48.6 12.8 No No
4ZSM_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 71.1 49 Yes Yes
2 empty 2.55 71.6 27 No No
3 empty 2.26 61.8 17.3 No No
4 empty 1.94 59.8 23.4 No No
5 empty 2.12 60.7 18.7 No No
6 empty 2.27 61.2 14.9 No No
7 empty 2.14 66.3 12.8 No No
8 empty 1.86 70.1 14.2 No No
9 empty 2.48 71.9 12 No No
10 empty 2.5 62.8 15.9 No No
4FSL_E Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 70.5 54.2 Yes Yes
2 empty 2.61 67 23.6 No No
3 empty 2.48 65.8 24.5 No No
4 empty 2.3 59.6 21.1 No No
5 empty 2.23 65.1 17.8 No No
6 empty 2.29 63.3 14.7 No No
7 empty 2.01 68.9 13.1 No No
8 empty 2.3 69.4 13.3 No No
9 empty 2.03 63 18.4 No No
10 empty 2.06 70.9 11.9 No No
4R91_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 72.1 27.9 Yes Yes
2 empty 2.25 57.2 29.2 No No
3 empty 2.19 62.9 22.1 No No
4 empty 2.04 64.7 17.2 No No
5 empty 2.09 66.5 12.2 No No
6 empty 2.12 66.1 11.8 No No
7 empty 1.94 62.4 12.7 No No
8 empty 1.8 60.8 17.7 No No
9 empty 1.87 50.2 13.5 No No
10 empty 2.13 62.7 11.1 No No
2FDP_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.41 70.2 56 Yes Yes
2 empty 2.21 58.3 20.9 No No
3 empty 2.22 66.1 13.4 No No
4 empty 2.01 64.7 16.9 No No
5 empty 2.48 64.5 14.2 No No
6 empty 2.2 67.8 13.9 No No
7 empty 2.48 64.6 12 No No
8 empty 2.51 66.8 14.1 No No
9 empty 1.92 71.8 13.1 No No
10 empty 2.23 62.2 11 No No
4K8S_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 70.2 54.3 Yes Yes
2 empty 2.04 63.1 16.6 No No
3 empty 2.42 63.2 16.5 No No
4 empty 2.2 67.4 13.7 No No
5 empty 2.25 63.4 16.1 No No
6 empty 1.98 69.3 10.1 No No
7 empty 2.15 69.6 8 No No
8 empty 1.9 71.3 12.3 No No
9 empty 2.05 69.1 11.8 No No
10 empty 2.55 66.5 10.7 No No
2WEZ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 68.8 46.6 Yes Yes
2 empty 2.19 59.3 20 No No
3 empty 2.15 69.5 14.8 No No
4 empty 1.84 80.9 15 No No
5 empty 1.95 58.7 13 No No
6 empty 2.49 66.4 21.1 No No
7 empty 2.29 74.3 13.3 No No
8 empty 2.09 64.3 12.7 No No
9 empty 2.2 60.6 13.4 No No
10 empty 2.09 60.5 11.4 No No
4WY1_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 70.1 63.6 Yes Yes
2 empty 2.26 59.6 19.7 No No
3 empty 1.95 62.2 22.4 No No
4 empty 2.3 67.2 15 No No
5 empty 2.38 71.3 14.4 No No
6 empty 2.23 59 18.3 No No
7 empty 2.13 65 12.5 No No
8 empty 2.1 63.5 12.2 No No
9 empty 2.14 67.1 21.9 No No
10 empty 2.61 68.2 12.8 No No
3UDK_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 68.6 63.4 Yes Yes
2 empty 1.95 64.1 20.4 No No
3 empty 2.2 67.5 16.7 No No
4 empty 2.06 61 20.8 No No
5 empty 2.11 59 19.4 No No
6 bound 2.3 69.2 13.2 No No
7 empty 2.17 73.9 10.4 No No
8 empty 2.26 68 9.2 No No
9 empty 1.99 64.6 12.4 No No
10 empty 2.35 50.6 16.3 No No
3L5E_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 72.2 29.6 Yes Yes
2 empty 2.34 59.4 34.9 No No
3 empty 2.13 60.3 21.1 No No
4 empty 2.25 61.6 14.3 No No
5 empty 2.02 60.6 13.3 No No
6 empty 2.16 64.9 10.6 No No
7 empty 1.93 67.3 11.7 No No
8 empty 1.94 63.9 13.4 No No
9 empty 2.01 53.5 13.1 No No
10 empty 2.22 56.3 11.6 No No
4DI2_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 71.3 52.5 Yes Yes
2 empty 2.1 59.8 21.5 No No
3 empty 2.33 66.8 19.5 No No
4 empty 2.46 65.1 14.7 No No
5 empty 1.96 63 15.2 No No
6 empty 2.1 66.2 11.5 No No
7 empty 2.06 69.3 9.9 No No
8 empty 1.77 67.3 12.2 No No
9 empty 2.13 56.2 14.1 No No
10 empty 2.52 69.1 11 No No
3K5G_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 70.7 41.1 Yes Yes
2 empty 2.24 64.8 28.7 No No
3 empty 2.19 60.9 18.6 No No
4 empty 2.21 65.3 14.6 No No
5 empty 2.22 68.8 12.6 No No
6 empty 2.34 66.5 14.8 No No
7 empty 2.01 67.3 14.3 No No
8 empty 2.65 68.1 13 No No
9 empty 1.92 67 11.9 No No
10 empty 1.9 60.7 15.4 No No
2QMD_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.34 64.2 54.5 Yes No
2 empty 2.17 61.2 21.2 No No
3 empty 1.94 55.3 16.7 No No
4 empty 2.27 64 11.2 No No
5 empty 1.95 60.1 13.3 No No
6 empty 1.94 67.2 11.2 No No
7 empty 1.98 61.9 13.2 No No
8 empty 2.36 65.9 13.7 No No
9 empty 1.98 55.1 11.5 No No
10 empty 2.01 58.9 12.2 No No
2ZHV_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 70.9 48.8 Yes Yes
2 empty 2.29 64.7 16.7 No No
3 empty 2.09 59.6 17.6 No No
4 empty 2.42 65.7 14 No No
5 empty 2.09 64.5 11.8 No No
6 empty 1.98 63 14.1 No No
7 empty 2.11 66.2 15.4 No No
8 empty 2.18 63.8 16 No No
9 empty 2.27 61.3 14.2 No No
10 empty 2.34 63.7 15.6 No No
1YM4_B Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 74 42.5 Yes No
2 empty 2.14 73.5 32.1 No No
3 empty 2.29 62.7 20.2 No No
4 empty 2.27 65.5 18.3 No No
5 empty 2.05 62.8 23.6 No No
6 empty 2.24 61.6 17.3 No No
7 empty 2.06 61.2 12.8 No No
8 empty 2.18 61.4 14.8 No No
9 empty 2.31 65.2 17.4 No No
10 empty 2.01 59.2 14.3 No No
3UQX_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 70.9 37.4 Yes Yes
2 empty 2.24 60.8 20.7 No No
3 empty 2.14 64.3 18.1 No No
4 empty 2.29 63.9 16.4 No No
5 empty 1.89 58.2 16.9 No No
6 empty 1.94 59.5 13.2 No No
7 empty 1.99 65.4 13.5 No No
8 empty 1.88 56.5 15.1 No No
9 empty 2.12 58.7 11.8 No No
10 empty 2.13 50 12.2 No No
3HW1_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 70 53.9 Yes Yes
2 empty 2.19 63.7 15.7 No No
3 empty 2.58 67.8 27.4 No No
4 empty 2.08 63.5 21.8 No No
5 empty 2.21 61 18.5 No No
6 empty 2.16 64.3 13.5 No No
7 empty 2.13 61.3 15.4 No No
8 empty 2.08 64.9 11.9 No No
9 empty 2.47 69.8 11.9 No No
10 empty 2.16 68.7 8.6 No No
3OHH_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 75.7 27.8 Yes Yes
2 empty 1.94 59 30.8 No No
3 empty 2.02 63.9 15.7 No No
4 empty 2.01 62.3 14.8 No No
5 empty 1.91 55 14.9 No No
6 empty 2.08 67 12.7 No No
7 empty 2.25 58.5 14.2 No No
8 empty 1.92 60.5 13.9 No No
9 empty 1.94 61.1 12.2 No No
10 empty 2.37 60.7 13.5 No No
4XXS_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 77.8 23.7 Yes Yes
2 empty 2.04 59.6 26.1 No No
3 empty 2.24 64 16.5 No No
4 empty 1.84 63.6 13.5 No No
5 empty 1.69 59.9 15.2 No No
6 empty 2.02 64.4 12.1 No No
7 empty 2.21 59.1 14 No No
8 bound 1.99 63.7 16.3 No No
9 empty 2.02 63 12.3 No No
10 empty 2.13 59.7 14.8 No No
4DI2_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 70.9 53.9 Yes Yes
2 empty 2.14 56.4 21.4 No No
3 empty 2.17 62.4 23.2 No No
4 empty 2.15 64 13 No No
5 empty 2.4 62.1 10.8 No No
6 empty 2.33 66 14.1 No No
7 empty 2.44 71.6 11.5 No No
8 empty 2.23 57.1 13.3 No No
9 empty 1.94 58.8 12.5 No No
10 empty 2.23 67.2 11.5 No No
3K5D_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 69.9 54 Yes Yes
2 empty 2.22 60.9 18.2 No No
3 empty 2.52 67.7 12.8 No No
4 empty 2.17 65.7 14.3 No No
5 empty 2.23 63.8 13.1 No No
6 empty 2.2 68.4 9.6 No No
7 empty 2.04 62.9 15.4 No No
8 empty 1.77 71.8 11.6 No No
9 empty 2.53 64.5 12.5 No No
10 empty 2.17 70.2 9.6 No No
4X7I_B Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 76.8 28.5 Yes No
2 bound 2.09 56.5 32.2 No No
3 empty 2.17 61.3 16.2 No No
4 empty 2.31 62.8 12.9 No No
5 empty 2.07 66.3 12.6 No No
6 empty 1.97 65.3 12.9 No No
7 empty 1.87 57.2 14.5 No No
8 empty 2.06 59.5 13.6 No No
9 empty 1.92 56.6 17.3 No No
10 empty 2.5 63 13.3 No No
5HDX_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 70.5 50.1 Yes Yes
2 empty 2.03 61.1 21.5 No No
3 empty 2.23 64.8 12.1 No No
4 empty 2.15 74 10.9 No No
5 empty 2.3 64.4 16.6 No No
6 empty 2.51 61.7 17.6 No No
7 empty 2.04 64.2 12.6 No No
8 empty 1.98 63.2 14 No No
9 empty 2.14 68.5 9.5 No No
10 empty 1.89 57.7 12.3 No No
4ZSR_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 68.4 53.7 Yes Yes
2 empty 2.49 67.1 21.8 No No
3 empty 2.28 64.4 15.7 No No
4 empty 1.87 61.6 19.7 No No
5 empty 2.18 60.7 17.3 No No
6 empty 1.99 62.9 15.8 No No
7 empty 2.18 70.3 12.5 No No
8 empty 2.02 65.3 11.7 No No
9 empty 2.04 58.8 14.3 No No
10 empty 2.14 67.9 15.4 No No
4TRW_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 73.4 37.9 Yes Yes
2 empty 1.89 71.5 29.5 No No
3 empty 2.14 63 23.6 No No
4 empty 2.45 64.8 25.3 No No
5 empty 2.6 66.2 11.9 No No
6 empty 2.13 61.6 17.1 No No
7 empty 2.08 65 17.5 No No
8 empty 2.02 69.8 12 No No
9 empty 2.07 69 22.1 No No
10 empty 2.11 66 9.8 No No
4KE1_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 75.7 41.5 Yes Yes
2 empty 2.19 63 26.9 No No
3 empty 2.34 61.8 18.8 No No
4 empty 2.05 61 22.2 No No
5 empty 2.41 68.5 12 No No
6 empty 2.43 63 14.3 No No
7 empty 2.15 66.5 12.9 No No
8 empty 2.25 64.5 14.1 No No
9 empty 2.2 64.7 11.9 No No
10 empty 2.14 61 12.9 No No
3L5D_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 71.4 34.4 Yes Yes
2 empty 2.36 61.5 28.9 No No
3 empty 2.12 65.1 20.7 No No
4 empty 2.36 60 17.8 No No
5 empty 2.27 64.1 11.2 No No
6 empty 2.08 62.8 13 No No
7 empty 1.89 57.1 12.2 No No
8 empty 2.07 66.3 12.9 No No
9 empty 1.96 67.7 11.3 No No
10 empty 2.66 70.1 13.7 No No
6C2I_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 70.3 37.4 Yes Yes
2 empty 2.02 70.9 22.9 No No
3 empty 2.23 61.1 20.3 No No
4 empty 2.28 69.3 14.5 No No
5 empty 2.14 64 15.3 No No
6 bound 1.86 64.5 11.4 No No
7 empty 2.32 63.5 12.7 No No
8 empty 2.19 59.7 17.7 No No
9 empty 2.29 70.9 17 No No
10 empty 2.11 64.2 15.3 No No
3DV5_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.21 70.6 40.8 Yes Yes
2 empty 2 74.5 30.4 No No
3 empty 2.17 65.3 24.4 No No
4 empty 2.16 60.2 20.1 No No
5 empty 2.25 61 18 No No
6 empty 2.31 66 17.9 No No
7 empty 2.13 68.8 12.9 No No
8 empty 1.98 64.8 10.9 No No
9 empty 2.52 71.7 10.6 No No
10 empty 2.16 66.1 13.5 No No
3R1G_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 71.4 55 Yes Yes
2 empty 2.21 61.1 21.1 No No
3 empty 2.05 59.5 20.4 No No
4 empty 2.42 65.7 21.2 No No
5 empty 2.17 69.3 15.3 No No
6 empty 2.76 64.5 15.8 No No
7 empty 2.07 64.2 14 No No
8 empty 1.95 68.7 10.5 No No
9 empty 2.46 71.3 11.4 No No
10 empty 2.4 64.4 15.5 No No
3DV1_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 71.7 53.9 Yes Yes
2 empty 2.19 64.6 22.5 No No
3 empty 2.17 65.3 21 No No
4 empty 2.38 61.9 19.7 No No
5 empty 2.28 67.4 15.8 No No
6 empty 2.06 66.8 14.9 No No
7 empty 1.82 65.1 12.4 No No
8 empty 2.04 56.2 18.1 No No
9 empty 2.42 61.6 13.5 No No
10 empty 2.49 64.2 12.5 No No
3EXO_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 66.5 53.1 Yes Yes
2 empty 2.21 63.3 17.1 No No
3 empty 2.1 59.8 18.4 No No
4 empty 2.39 62.6 15.9 No No
5 empty 2.1 61.4 13.7 No No
6 empty 1.98 63 12.1 No No
7 empty 2.11 62.1 14.8 No No
8 empty 2.16 55.3 11.5 No No
9 empty 2.3 61.9 16.5 No No
10 empty 2 53.8 13.8 No No
4WY6_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 70.1 30.4 Yes Yes
2 empty 1.94 65.1 25.5 No No
3 empty 2.26 63.3 16.2 No No
4 empty 1.72 61.2 15.1 No No
5 bound 1.72 57.5 20.9 No No
6 empty 1.88 62.5 13.3 No No
7 empty 2.02 65.9 10.3 No No
8 empty 2.04 62.2 12.4 No No
9 empty 2.21 60.1 14.4 No No
10 empty 2.37 71.2 12.5 No No
4FGX_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 66.5 40.9 Yes Yes
2 empty 2.13 71 22.6 No No
3 empty 2.17 59 22.8 No No
4 empty 2.19 63.9 17.3 No No
5 empty 2.35 62.5 16.2 No No
6 empty 1.97 63 13.4 No No
7 empty 2.03 65 12.4 No No
8 empty 2.11 56.8 14.2 No No
9 empty 2.54 63.8 14.6 No No
10 empty 2.14 64.9 10.6 No No
4B1E_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 67.2 39.2 Yes Yes
2 empty 2.37 71.7 34.1 No No
3 empty 2.25 66.9 17 No No
4 empty 2.18 58.3 19.3 No No
5 empty 2.21 61.6 15.7 No No
6 empty 2.13 63.3 13.3 No No
7 empty 2.03 72.6 10.9 No No
8 empty 2.29 66.7 11.1 No No
9 empty 2.32 69.9 14 No No
10 empty 2.54 71.7 8.3 No No
4KE0_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 70.3 53.7 Yes Yes
2 empty 2.27 64.4 24.3 No No
3 empty 2.2 58 19.2 No No
4 empty 2.16 67.3 11.9 No No
5 empty 2.32 63 13.3 No No
6 empty 2.46 61.7 14.2 No No
7 empty 2.19 65.7 11.5 No No
8 empty 2.44 68.1 14.1 No No
9 empty 2.45 68.3 12.8 No No
10 empty 2.03 56.9 11.6 No No
4RCD_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.21 71.9 49.9 Yes Yes
2 empty 2.14 60.9 20.3 No No
3 empty 1.98 58.5 23 No No
4 empty 2.19 68.2 16.7 No No
5 empty 2.11 64.4 11.6 No No
6 empty 1.98 60.3 11.6 No No
7 empty 2.08 60.7 13.5 No No
8 empty 2.17 63.5 15.8 No No
9 empty 2.32 63.8 13.6 No No
10 empty 2.51 68.6 12.2 No No
4I1C_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 67.9 49.3 Yes Yes
2 empty 2.14 68.7 16.3 No No
3 empty 1.79 67.4 20.5 No No
4 empty 1.95 60.5 19.2 No No
5 empty 2.38 69.4 16.3 No No
6 empty 2.31 63.8 21.2 No No
7 empty 2.06 58.6 17.5 No No
8 empty 2.06 60.8 14.8 No No
9 empty 2.26 62.8 15 No No
10 empty 1.99 61.1 19.3 No No
4ZPF_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 70.6 54.4 Yes Yes
2 empty 2.1 60.2 20.8 No No
3 empty 2.36 65 16.2 No No
4 empty 2.64 62.8 15.6 No No
5 empty 2.06 59.9 14.4 No No
6 empty 1.88 61.5 16 No No
7 empty 2.06 70.9 8.8 No No
8 empty 2.15 62.6 16.3 No No
9 empty 2.5 69.3 18.2 No No
10 empty 2.02 59.5 13.2 No No
2ZHS_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 69.5 54.8 Yes Yes
2 empty 1.95 60.4 20 No No
3 empty 2.29 65.8 23.1 No No
4 empty 2.26 63.4 17.9 No No
5 empty 2.26 67.3 19 No No
6 empty 2.14 63.4 15.9 No No
7 empty 2.56 61.5 24.1 No No
8 empty 2.16 69 9.2 No No
9 empty 2.27 66.4 10.9 No No
10 empty 2.37 68.8 12.9 No No
2VIZ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 71.1 54.5 Yes Yes
2 empty 2.29 61.1 30.8 No No
3 empty 2.17 69.3 22.7 No No
4 empty 2.39 64.3 20.5 No No
5 empty 2.55 66.5 11.5 No No
6 empty 2.19 57.4 14.2 No No
7 empty 2.39 62.2 14.4 No No
8 empty 2.19 59.7 12.2 No No
9 empty 1.95 72.9 9.9 No No
10 empty 2.03 63.1 10.3 No No
3DV1_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 70.2 52.6 Yes Yes
2 empty 2.11 65.1 16.4 No No
3 empty 2.26 67.4 16.5 No No
4 empty 2.17 68.4 11.3 No No
5 empty 2.28 64.8 10.9 No No
6 empty 2.3 63.3 18.5 No No
7 empty 1.98 68.4 11.1 No No
8 empty 2.51 66.3 9.6 No No
9 empty 2.24 58.6 15.7 No No
10 empty 2.17 56 14.3 No No
4LXK_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 73.4 45.4 Yes Yes
2 empty 2.25 62 22.2 No No
3 empty 2.16 64.1 14.8 No No
4 empty 1.85 56.9 13.4 No No
5 empty 2.36 66.7 18 No No
6 empty 2.17 69.2 13.4 No No
7 empty 1.89 67 11.4 No No
8 empty 2.47 70.2 12.1 No No
9 empty 2.43 69 9.9 No No
10 empty 2.5 59.9 12.3 No No
3KMX_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 69.3 53.5 Yes Yes
2 empty 2.2 63.1 20.5 No No
3 empty 2.23 58.9 20.7 No No
4 empty 2.44 70.5 17.7 No No
5 empty 2.09 53.4 16.4 No No
6 empty 2.12 62.1 13.8 No No
7 empty 2.27 65.9 17.6 No No
8 empty 2.42 61.6 12.5 No No
9 empty 2.13 72.8 11.7 No No
10 empty 2.18 66.6 11.3 No No
4JPC_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 69.7 53.1 Yes Yes
2 empty 2.16 63.8 32.5 No No
3 empty 2.21 68.2 18.2 No No
4 empty 2.37 66.9 15.2 No No
5 empty 1.88 61.5 21.9 No No
6 empty 1.99 50.7 17 No No
7 empty 2.39 66.4 12 No No
8 empty 2.23 71.2 14.4 No No
9 empty 2.16 59.5 17 No No
10 empty 2.09 65.9 13.2 No No
2Q11_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 71.4 37.2 Yes Yes
2 empty 1.93 74.7 29.4 No No
3 empty 2.16 65.6 17.4 No No
4 empty 2.06 67.3 9.9 No No
5 empty 2.05 70.8 14.4 No No
6 empty 2.02 62.1 14.8 No No
7 empty 2.21 62.3 14.5 No No
8 empty 1.67 71 10.3 No No
9 empty 2.49 67.3 10.8 No No
10 empty 2.15 58.9 11.3 No No
3FKT_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 72 40.9 Yes Yes
2 empty 2.13 69.2 36.7 No No
3 empty 2.14 61.3 21.2 No No
4 empty 2.38 66.3 14.8 No No
5 empty 2.4 69 17.8 No No
6 empty 2.13 65.3 13.5 No No
7 empty 2.09 70.3 12.5 No No
8 empty 2.09 61.1 14.3 No No
9 empty 2.39 67.4 15 No No
10 empty 1.95 54.4 14.4 No No
5MCO_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.25 70.4 39.1 Yes Yes
2 empty 2.42 70 26.4 No No
3 empty 2.13 72 26 No No
4 empty 2.2 57.8 17.7 No No
5 empty 1.89 58.2 16.1 No No
6 empty 2.34 67.3 13.2 No No
7 empty 1.9 66.6 12.9 No No
8 empty 2.12 61.9 12.9 No No
9 empty 2.26 64.1 13.6 No No
10 empty 2.08 65.5 9.8 No No
4PZX_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 68.5 53.5 Yes Yes
2 empty 2.33 62.4 24.9 No No
3 empty 2.13 66.1 26.7 No No
4 empty 2.22 64.8 15.7 No No
5 empty 2.2 61.9 19.6 No No
6 empty 2.45 69.9 13 No No
7 empty 1.87 57.5 13.7 No No
8 empty 2.46 54.5 12.8 No No
9 empty 2.52 68.7 13.2 No No
10 empty 2.27 66.1 12.2 No No
3DV5_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 70.7 52.7 Yes Yes
2 empty 2.05 65.5 22.4 No No
3 empty 2.12 60.2 18.7 No No
4 empty 2.21 64.5 15.4 No No
5 empty 2.07 66.4 11.2 No No
6 empty 1.89 70 11.5 No No
7 empty 2.5 65.3 11.8 No No
8 empty 2.25 58.7 15.7 No No
9 empty 2.48 67.9 16.7 No No
10 empty 2.31 69.2 9.4 No No
3CKP_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 69.2 54.1 Yes Yes
2 empty 2.14 64.1 36 No No
3 empty 2.18 61.4 20.1 No No
4 empty 2.51 67.1 18 No No
5 empty 2.27 60.4 15 No No
6 empty 1.96 67.2 13.1 No No
7 empty 2.44 72.3 10.4 No No
8 empty 2.1 62.1 16.7 No No
9 empty 2.51 60.4 15.6 No No
10 empty 2.46 65.7 15.1 No No
2VA7_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 70 45.3 Yes Yes
2 empty 2.53 70.5 13.9 No No
3 empty 2.29 59.1 18.1 No No
4 empty 2.41 67.3 17.2 No No
5 empty 2.25 64.6 12.8 No No
6 empty 2.1 64.3 13.2 No No
7 empty 2.21 69 13.6 No No
8 empty 1.89 64 10.3 No No
9 empty 1.7 60.1 11.7 No No
10 empty 2.14 63.1 10.9 No No
2QK5_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.31 70.8 55.2 Yes Yes
2 empty 2.24 57.3 20.4 No No
3 empty 2.14 63.4 15.3 No No
4 empty 2.5 70 16.7 No No
5 empty 2.02 56.6 15.6 No No
6 empty 2.39 62 18.2 No No
7 empty 2.05 63.1 17.1 No No
8 empty 2.36 69.5 15.1 No No
9 empty 2.01 71.1 11.2 No No
10 empty 2.03 65.2 11.4 No No
3TPL_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 72 49.8 Yes Yes
2 empty 2.16 64.3 37.8 No No
3 empty 2.2 66.6 20.1 No No
4 empty 2.41 70.7 13.1 No No
5 empty 1.98 65.3 12.4 No No
6 empty 2 51.8 10.6 No No
7 empty 1.44 64 12.7 No No
8 empty 2.66 67.3 10.5 No No
9 empty 1.99 69.4 9.6 No No
10 empty 2.11 67.2 8.1 No No
4GID_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.2 61.1 35.9 Yes No
2 bound 2.34 80.6 27.1 Yes Yes
3 bound 2.33 59.9 19.7 No No
4 empty 2.28 57.8 15.1 No No
5 empty 2.05 51.5 15.6 No No
6 empty 2.02 69 12 No No
7 empty 1.95 63.6 11.3 No No
8 empty 1.99 67.9 11.3 No No
9 empty 2.44 64 14.5 No No
10 empty 2.18 61.5 12.7 No No
2NTR_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 72.9 54 Yes Yes
2 empty 2.05 61.6 21.4 No No
3 empty 2.21 63.5 18.1 No No
4 empty 2.52 60 17.7 No No
5 empty 2.22 67.3 12.1 No No
6 empty 2 69.2 12.4 No No
7 empty 2.28 63.4 16 No No
8 empty 2.02 64.9 14.1 No No
9 empty 2.06 60.1 12.8 No No
10 empty 2.17 61.3 12 No No
2HM1_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 69 54.3 Yes Yes
2 empty 2.17 58 21.4 No No
3 empty 2.5 68 15.1 No No
4 empty 2.55 65.8 16.7 No No
5 empty 2.31 65 15.1 No No
6 empty 2.08 62.7 15.5 No No
7 empty 2.12 71.6 12.6 No No
8 empty 2.23 69.1 14.3 No No
9 empty 2.27 59.3 15.4 No No
10 empty 2.35 68.6 17.6 No No
6FGY_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 71.6 53.8 Yes Yes
2 empty 2.54 68.3 35.6 No No
3 empty 2.28 61.5 19.3 No No
4 empty 2.27 67.1 16.6 No No
5 empty 2.2 62.3 16.2 No No
6 empty 2.09 61.4 13 No No
7 empty 2.04 61.9 14.9 No No
8 empty 2.32 68.1 10.4 No No
9 empty 2.1 58.8 12.7 No No
10 empty 2.41 70.1 9.5 No No
3KMY_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 70.5 52.5 Yes Yes
2 empty 2.18 64 20.6 No No
3 empty 2.31 58.2 20.6 No No
4 empty 2.09 53.1 15.6 No No
5 empty 2.46 71.4 16.2 No No
6 empty 2.1 64.4 18.5 No No
7 empty 2.42 62.1 13.9 No No
8 empty 2.23 65.2 17.1 No No
9 empty 2.16 72 11.1 No No
10 empty 2.05 67.7 11.5 No No
3R2F_E Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 71.6 54.8 Yes Yes
2 empty 2.1 61.9 13.9 No No
3 empty 2.08 61.9 13 No No
4 empty 2.05 74 12.1 No No
5 empty 2.64 73.2 14.7 No No
6 empty 2.11 61.9 15.7 No No
7 empty 2.42 66.9 14 No No
8 empty 2.13 65.2 13.7 No No
9 empty 2.01 66.9 13.1 No No
10 empty 1.95 67.2 10.3 No No
3MSJ_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 72.7 39.3 Yes Yes
2 empty 1.88 60.2 26.6 No No
3 bound 2.13 65.7 19.1 No No
4 bound 2.21 65.9 19.8 No No
5 empty 2.05 57.3 17.8 No No
6 empty 1.81 65.5 14.6 No No
7 empty 2.12 65.3 13.9 No No
8 empty 2.2 67.6 9.8 No No
9 bound 2.57 66.7 10.8 No No
10 empty 2.08 69.6 12.5 No No
3SKG_E Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.26 71.2 53.7 Yes Yes
2 empty 2.04 63.6 15.2 No No
3 empty 2.3 59.5 16.9 No No
4 empty 2.04 72.8 15.7 No No
5 empty 1.98 59.9 16.1 No No
6 empty 2.63 75.8 18 No No
7 empty 2.04 67.9 14.6 No No
8 empty 2.24 68.2 12.2 No No
9 empty 2.24 68.6 18.9 No No
10 empty 2.32 69.2 13.9 No No
2B8V_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.49 72.3 40.4 Yes Yes
2 empty 2.41 65 28.6 No No
3 empty 2.05 61.7 25.2 No No
4 empty 2.26 60.3 14.1 No No
5 empty 2.35 64.7 13 No No
6 empty 2.1 49.7 20.7 No No
7 empty 1.98 68.1 12 No No
8 empty 2.51 60.2 14.3 No No
9 empty 2.39 68.6 14.1 No No
10 empty 2.23 61.6 12.9 No No
3ZOV_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 71.3 47.7 Yes Yes
2 empty 2.28 65.8 34.2 No No
3 empty 2.62 64.4 21.3 No No
4 empty 2.35 66.7 20.4 No No
5 empty 2.32 61.7 18.1 No No
6 empty 2.09 64 12.4 No No
7 empty 2.3 63.5 14 No No
8 empty 2.17 61.3 13.8 No No
9 empty 2.51 58.5 24.4 No No
10 bound 2.27 67.5 16 No No
2ZJJ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.4 69.8 54.5 Yes Yes
2 empty 2.26 62.2 24.6 No No
3 empty 2.4 63 18.8 No No
4 empty 2.12 65.1 13.1 No No
5 empty 2.64 63.6 15.4 No No
6 empty 2.23 68.4 9.8 No No
7 empty 2.22 64.5 15.3 No No
8 empty 2.21 64.5 16.6 No No
9 empty 2.16 67.3 11.5 No No
10 empty 2.54 71.1 13.8 No No
2IRZ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.33 69.4 53.5 Yes Yes
2 empty 1.98 60 24.3 No No
3 empty 2.38 64.4 18.7 No No
4 empty 2.32 66.4 14.5 No No
5 empty 2.49 56.5 12.1 No No
6 empty 2.08 68.6 10 No No
7 empty 2.32 64.3 11.4 No No
8 empty 2.04 54.8 12.7 No No
9 empty 2.15 66 10.1 No No
10 empty 2.6 64.9 13.6 No No
6BFW_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 71 40 Yes Yes
2 bound 2.05 59.6 32.7 No No
3 empty 2.34 59.1 19 No No
4 empty 2.07 62.5 16.4 No No
5 empty 2.03 65.4 12.7 No No
6 empty 2.08 60.2 13.2 No No
7 empty 2.02 60.8 13.6 No No
8 empty 2.04 60 15 No No
9 bound 2.26 57.7 11.3 No No
10 empty 2.51 69.4 11 No No
3KYR_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.32 69.3 52 Yes Yes
2 empty 2.31 65.8 18.7 No No
3 empty 2.18 60.6 14.7 No No
4 empty 2.59 64.8 16.6 No No
5 empty 2.16 60.8 17.8 No No
6 empty 2.21 67.9 15.4 No No
7 empty 2.16 69.3 15 No No
8 empty 2.3 66.2 18.8 No No
9 empty 2.56 72.7 12 No No
10 empty 2.19 66.1 12.3 No No
4D8C_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.19 70.8 54.6 Yes Yes
2 empty 2.11 64.8 17.2 No No
3 empty 2.25 64.7 14.6 No No
4 empty 2.2 61.9 16.3 No No
5 empty 2.37 60.6 16.8 No No
6 empty 2.19 68.4 12.8 No No
7 empty 2.16 67.2 14.1 No No
8 empty 2.36 67.2 14.4 No No
9 empty 2.52 65.2 12.7 No No
10 empty 2.49 69.1 12.6 No No
4LXA_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 71.1 54.2 Yes Yes
2 empty 2.12 58.2 20.1 No No
3 empty 2.22 74.8 14.7 No No
4 empty 2.33 60.9 14.7 No No
5 empty 2.26 64.7 15.2 No No
6 empty 2.44 61.6 15.2 No No
7 empty 2.18 70.5 11.9 No No
8 empty 2.55 61.7 15.5 No No
9 empty 2.15 69.3 11.3 No No
10 empty 2 56.6 13.3 No No
4DJY_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 66.8 54.4 Yes Yes
2 empty 2.16 62.2 20.3 No No
3 empty 2.17 58.9 13.7 No No
4 empty 2.23 64.9 13.2 No No
5 empty 1.94 61.8 12.7 No No
6 empty 2.12 64.5 12.5 No No
7 empty 2.08 66.2 11.1 No No
8 empty 1.97 59.2 11.3 No No
9 empty 1.95 60.2 12.2 No No
10 empty 2.03 52.8 13.4 No No
4I0H_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 70 39.9 Yes Yes
2 empty 2.1 69.2 34.1 No No
3 empty 2.43 62.6 22.3 No No
4 empty 2.29 63.2 15.2 No No
5 empty 2.4 61.7 25.7 No No
6 empty 1.96 63.2 10.2 No No
7 empty 2.18 69.5 9.8 No No
8 empty 1.93 68.9 13.9 No No
9 empty 2.69 69.5 11.2 No No
10 empty 2.06 67.4 13.7 No No
3UDH_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 67.4 51.1 Yes Yes
2 empty 2.12 64.3 28.8 No No
3 empty 2.22 65.9 16.7 No No
4 empty 2.18 57.6 20.6 No No
5 empty 2.12 57.8 19.4 No No
6 empty 2.14 67.4 11.6 No No
7 empty 1.97 62.1 12.7 No No
8 empty 2.03 62.6 11.8 No No
9 empty 2.53 70.3 12.7 No No
10 empty 1.7 48.8 12.8 No No
2VKM_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.21 70.1 53.9 Yes Yes
2 empty 2.56 68 19.5 No No
3 empty 1.96 57.9 21.6 No No
4 empty 2.22 62.3 21.1 No No
5 empty 2.2 64.1 16.8 No No
6 empty 2.15 63.2 13.3 No No
7 empty 2.16 70.3 11.8 No No
8 empty 2.45 58.5 15.9 No No
9 empty 2.13 64.9 12.7 No No
10 empty 2.26 68.8 16.4 No No
4DJV_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 69.1 30.4 Yes Yes
2 empty 2.18 59.9 28.1 No No
3 empty 2.3 57.4 22.8 No No
4 empty 2.25 63.6 19.5 No No
5 empty 2.28 62.2 16.6 No No
6 empty 2.04 63.7 13.4 No No
7 empty 2.08 70 12 No No
8 empty 2.03 59 12.5 No No
9 empty 1.94 61.9 12 No No
10 empty 2.45 68.5 14 No No
3K5C_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.4 71.4 48.8 Yes Yes
2 empty 1.97 63.1 21.8 No No
3 empty 2.29 63.6 16.5 No No
4 empty 2.15 60.9 16.9 No No
5 empty 2.27 63.8 17.3 No No
6 empty 2.05 68 12.9 No No
7 empty 2.56 69.3 11.6 No No
8 empty 1.92 64.7 12 No No
9 empty 1.92 70.2 11.5 No No
10 empty 2.58 70 14.8 No No
3CKP_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 70.7 53.5 Yes Yes
2 empty 2.58 65.6 28.6 No No
3 empty 2.26 63.1 19.1 No No
4 empty 2.29 58.7 15.8 No No
5 empty 1.98 62.9 19.4 No No
6 empty 2.09 59.4 12.6 No No
7 empty 2.03 59.9 16.4 No No
8 empty 2.12 64.6 12.2 No No
9 empty 1.95 67.6 10.4 No No
10 empty 2.53 67.8 17.5 No No
3S7L_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 72 35.7 Yes No
2 empty 1.97 69.3 31.7 No No
3 empty 2.44 67.2 24.4 No No
4 empty 2.17 60.5 14.6 No No
5 empty 2.43 65.3 18 No No
6 empty 2.19 62 19.6 No No
7 empty 2.33 68.6 14 No No
8 empty 2.2 61 17.4 No No
9 empty 2.23 61.9 13.3 No No
10 empty 2.48 71.7 10.5 No No
3UFL_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 66.2 53.3 Yes Yes
2 empty 2.05 61.3 21.1 No No
3 empty 2.24 63 16.3 No No
4 empty 2.21 61.4 15 No No
5 empty 1.92 64.4 9.9 No No
6 empty 2.18 54.7 15.4 No No
7 empty 1.95 62 13.4 No No
8 empty 1.9 65.6 12.7 No No
9 empty 2.07 59.5 13.3 No No
10 empty 2.05 59 12.9 No No
4ZPG_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 68.7 49.2 Yes Yes
2 empty 2.08 60.3 23.1 No No
3 empty 2.29 64.8 18.1 No No
4 empty 2.1 61.9 19.3 No No
5 empty 2.46 67 17 No No
6 empty 2.06 66.9 8.7 No No
7 empty 2.03 57.1 12 No No
8 empty 2.18 60.7 12.8 No No
9 empty 2.24 67.5 14.6 No No
10 empty 2.01 58.9 13.4 No No
3LPJ_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 71.1 54.3 Yes Yes
2 empty 2.52 65.7 24.5 No No
3 empty 2.2 66.1 21.1 No No
4 empty 1.99 61.1 20.2 No No
5 empty 2.14 62.9 16.9 No No
6 empty 2.08 70.6 10.2 No No
7 empty 2.01 66.5 11.3 No No
8 empty 2.05 58.4 14.2 No No
9 empty 2.27 56.6 13.1 No No
10 empty 2.03 69.7 14.6 No No
3L5F_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 73.6 38.2 Yes Yes
2 empty 2.43 60.6 42.9 No No
3 empty 2.39 62.6 17.9 No No
4 empty 2.17 63.6 21.5 No No
5 empty 1.96 65.5 13.8 No No
6 empty 1.97 69.3 11.3 No No
7 empty 2.12 58.6 12 No No
8 empty 2.47 64.9 12.3 No No
9 empty 1.83 53.3 13.4 No No
10 empty 2.03 54.3 13 No No
3L38_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 74.7 53.4 Yes Yes
2 empty 2.48 67.7 22.7 No No
3 empty 1.83 57.1 23.3 No No
4 empty 2.25 65.6 22.2 No No
5 empty 2.44 68.2 18.5 No No
6 empty 2.15 62.3 20 No No
7 empty 2.39 66.1 20.1 No No
8 empty 2.16 64.9 17.3 No No
9 empty 2.07 67.6 11.8 No No
10 empty 1.93 58.1 14.2 No No
4H3G_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 77.5 26.2 Yes Yes
2 empty 2.16 61.3 27.9 No No
3 empty 2.19 62.3 19.7 No No
4 empty 2.24 63.1 22.1 No No
5 empty 2.26 59.3 13.9 No No
6 empty 2.08 61.9 13 No No
7 empty 2.23 58.7 14.7 No No
8 empty 1.95 65.8 11.8 No No
9 empty 1.97 69.4 11.9 No No
10 empty 2.52 66.9 14.1 No No
3L3A_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 70.4 33.6 Yes Yes
2 empty 2.28 67.3 24.5 No No
3 bound 1.91 79 23.8 No No
4 empty 2.45 68.2 16.7 No No
5 empty 2.17 64.9 14.6 No No
6 empty 2.21 65 17.5 No No
7 empty 2.28 68 13.8 No No
8 empty 2.15 64.4 15.3 No No
9 empty 2.22 61.3 13.8 No No
10 empty 2.27 62.7 15 No No
3N4L_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 71.4 51.3 Yes Yes
2 empty 2.31 63.6 14 No No
3 empty 2.2 62 15.2 No No
4 empty 1.75 56.8 15.6 No No
5 empty 2.18 67.8 13.1 No No
6 empty 1.94 65.5 16.6 No No
7 empty 2.3 63.6 14.1 No No
8 empty 2.46 75.2 8.8 No No
9 empty 2.2 67.5 11.9 No No
10 empty 2.15 66.8 14.3 No No
4H3J_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 72.1 43.7 Yes Yes
2 empty 2.14 60.4 27.4 No No
3 empty 2.12 64.3 20 No No
4 empty 2.21 58.5 14 No No
5 empty 2.16 57 13.6 No No
6 empty 2.1 62.3 12.6 No No
7 empty 2.11 65.9 11.9 No No
8 empty 1.95 61.4 12.3 No No
9 empty 1.9 62.3 16.3 No No
10 empty 2.64 65.6 13.6 No No
4J0V_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 70.8 53 Yes Yes
2 empty 2.26 67.2 14.1 No No
3 empty 2.34 61.9 17.8 No No
4 empty 2.53 66.7 17.6 No No
5 empty 2.44 55.4 22.2 No No
6 empty 2.41 77.3 14.5 No No
7 empty 2.25 62.5 16.7 No No
8 empty 2.54 66.9 13.3 No No
9 empty 1.95 65.5 13.3 No No
10 empty 2.15 68.9 11.2 No No
4K8S_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 72.3 53.3 Yes Yes
2 empty 2.01 64 14.1 No No
3 empty 1.99 66 13.1 No No
4 empty 2.25 67.8 13.1 No No
5 empty 2.2 67.3 11 No No
6 empty 2.16 57.5 12 No No
7 empty 2.5 71.6 11.2 No No
8 empty 2.43 66.7 13.1 No No
9 empty 2.08 67.1 11.1 No No
10 empty 2.59 71.2 11.7 No No
3NSH_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 70.3 54.7 Yes Yes
2 empty 2.02 58.4 19.6 No No
3 empty 2.38 62 17.7 No No
4 empty 1.78 72.3 12.3 No No
5 empty 2.09 67.8 15.9 No No
6 empty 2.31 65.3 14.3 No No
7 empty 2.25 65.6 14.1 No No
8 empty 2.36 62.5 12.6 No No
9 empty 2.2 63.5 11 No No
10 empty 2.08 65.5 9.3 No No
6BFD_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.25 71.1 55.5 Yes Yes
2 empty 2.46 70.3 14.7 No No
3 empty 2.14 66.4 21 No No
4 empty 2.14 57.2 21.1 No No
5 empty 2.12 72.6 10.4 No No
6 empty 2.33 58.1 15.6 No No
7 empty 2.1 63.3 14.9 No No
8 empty 1.96 61 14.3 No No
9 empty 2.13 65.2 12.6 No No
10 empty 2.41 62.6 14.7 No No
4HZT_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 69.6 63.7 Yes Yes
2 empty 2.32 68.7 16.4 No No
3 empty 1.99 60.6 13.7 No No
4 empty 1.99 65.7 20.3 No No
5 empty 2.21 60.1 15.1 No No
6 empty 2.17 62 19 No No
7 empty 2.01 66.1 11 No No
8 empty 2.17 66.8 11.5 No No
9 empty 2.39 69.8 11.6 No No
10 empty 2.56 59 18.8 No No
4D88_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.19 69.4 54.7 Yes Yes
2 empty 2.41 72.3 26.1 No No
3 empty 2.27 62.8 21.8 No No
4 empty 2.03 70 9.5 No No
5 empty 2.09 67.8 21.4 No No
6 empty 2.39 68.6 15 No No
7 empty 2.6 69.7 9.8 No No
8 empty 2.49 65 13.1 No No
9 empty 2.03 59 12.2 No No
10 empty 2.44 70.4 8.4 No No
3DM6_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.33 63.1 31.1 Yes No
2 bound 2.41 77.2 27.2 No No
3 empty 1.91 56.5 15.9 No No
4 empty 2.06 63.2 15.2 No No
5 empty 1.95 57.1 15.8 No No
6 empty 2.14 68.3 12.4 No No
7 empty 2.01 58.9 14.8 No No
8 empty 1.88 62.7 11.6 No No
9 empty 1.95 62.6 13.1 No No
10 empty 1.97 65.1 13.5 No No
3SKF_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.21 71.1 53.2 Yes Yes
2 empty 2.18 60.5 22.4 No No
3 empty 2.09 66.1 22.9 No No
4 empty 2.66 79.3 11.2 No No
5 empty 1.99 59.2 16.4 No No
6 empty 2.58 60.8 19.8 No No
7 empty 2.09 64.7 12.6 No No
8 empty 1.86 70.2 14.7 No No
9 empty 1.96 59.5 13.4 No No
10 empty 2.39 67.9 12.1 No No
3KMX_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 69.6 55.1 Yes Yes
2 empty 2.53 66 20.4 No No
3 empty 1.96 63.5 21.9 No No
4 empty 2.11 64 20.7 No No
5 empty 2.15 62.3 20.1 No No
6 empty 2.17 71.8 11.9 No No
7 empty 2.05 66.2 11.8 No No
8 empty 2.25 57.5 14.6 No No
9 empty 2.02 59 14.3 No No
10 empty 2.54 68.2 11.8 No No
4I0Z_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 69.2 47.2 Yes Yes
2 empty 2.12 68.8 34.2 No No
3 empty 2.38 68.5 25.3 No No
4 empty 1.94 62 19.6 No No
5 empty 2.07 61.2 17.4 No No
6 empty 2.13 63.3 10.4 No No
7 empty 2.01 60.8 16.4 No No
8 empty 2.01 64.3 11.9 No No
9 empty 2.52 61.5 15.5 No No
10 empty 2.29 64.6 15.8 No No
2ZHR_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 70.6 52.1 Yes Yes
2 empty 2.21 60.3 18.7 No No
3 empty 2.25 65.4 19.8 No No
4 empty 2.25 58.9 18.2 No No
5 empty 1.81 73.2 13.4 No No
6 empty 2.41 65.6 13.9 No No
7 empty 2.13 67.9 13.1 No No
8 empty 2.12 70.7 10.7 No No
9 empty 2.1 61.2 15.3 No No
10 empty 2.09 70.6 11.1 No No
5HE7_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 72.8 41.7 Yes Yes
2 empty 2.03 66 29.4 No No
3 empty 2.24 60.1 37.9 No No
4 empty 2.19 66.5 20.7 No No
5 empty 2.18 72 11.7 No No
6 empty 2.1 64.4 16.2 No No
7 empty 2.03 66.8 10.9 No No
8 empty 2.5 62.5 16 No No
9 empty 2.13 65.1 18.1 No No
10 empty 2.21 67.4 12.2 No No
3K5C_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 70.6 54.6 Yes Yes
2 empty 2.14 58.1 20.5 No No
3 empty 2.21 74.4 14.9 No No
4 empty 2.37 64.2 15 No No
5 empty 2.28 63 14.8 No No
6 empty 2.43 62.8 13.4 No No
7 empty 2.29 67.9 12.3 No No
8 empty 2.56 64.1 14.2 No No
9 empty 1.89 63.9 14.3 No No
10 empty 2.14 70.3 10.1 No No
4I0F_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 67.9 48.5 Yes Yes
2 empty 2.22 67.1 18.9 No No
3 empty 2.28 76.4 17.1 No No
4 empty 2.04 64.6 17.6 No No
5 empty 2.04 60.3 14.5 No No
6 empty 2.1 63.5 20.5 No No
7 empty 2.31 68.3 16.5 No No
8 empty 2.35 66.6 17 No No
9 empty 2.06 65.4 12.6 No No
10 empty 2.27 63.6 14.2 No No
5T1U_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 71 47.8 Yes Yes
2 empty 2.04 59.9 20.4 No No
3 empty 2.26 70.6 15.8 No No
4 empty 2.06 64 19.7 No No
5 empty 1.99 62.5 21.5 No No
6 empty 1.96 69.4 18.4 No No
7 empty 2.44 65.7 16.1 No No
8 empty 1.98 64.9 12.8 No No
9 empty 2.02 65.6 11.8 No No
10 empty 2.26 64.8 14.1 No No
2QU3_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 69.5 47.9 Yes Yes
2 empty 2.16 62.8 20.3 No No
3 empty 2.2 68.9 18.1 No No
4 empty 2.06 57.9 20.4 No No
5 empty 2.11 60.7 17.3 No No
6 empty 2.11 59.4 12.5 No No
7 empty 2.45 70.3 12.2 No No
8 empty 2.49 68 9.2 No No
9 empty 2.01 58.2 12.1 No No
10 empty 2.1 59.8 14.3 No No
2OAH_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 72.8 54.3 Yes Yes
2 empty 2.07 61.7 22.7 No No
3 empty 2.07 50.3 20 No No
4 empty 2.35 67.7 12.9 No No
5 empty 2.16 58.5 16.6 No No
6 empty 1.99 67.6 13 No No
7 empty 2.39 60 12.2 No No
8 empty 2.21 64 13.6 No No
9 empty 1.87 57 13.2 No No
10 empty 2.55 68.2 14.5 No No
6DMI_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 71.9 38.6 Yes Yes
2 empty 2.24 62.4 35.4 No No
3 empty 1.79 65.5 19.1 No No
4 empty 2.18 62.1 17.6 No No
5 empty 2.71 66.3 23.7 No No
6 empty 2.32 67.5 16.8 No No
7 empty 1.91 63.5 13.4 No No
8 empty 1.93 66.1 11 No No
9 empty 2.15 65.5 11.2 No No
10 empty 2.47 69.9 9 No No
4GID_C Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 56.3 31.9 Yes No
2 bound 2.3 66.8 27.2 No No
3 bound 2.37 81.1 25.8 No No
4 empty 2.37 63.3 17.1 No No
5 empty 2.05 53.8 14.6 No No
6 empty 1.99 63.6 12.5 No No
7 empty 2.09 63.6 11.6 No No
8 empty 2.1 59.1 14 No No
9 empty 2.62 63.3 15.6 No No
10 empty 1.84 58 14.8 No No
4ZSM_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 67.9 53.9 Yes Yes
2 empty 2.08 61.7 18.2 No No
3 empty 2.25 58 17.4 No No
4 empty 2.41 71.5 16.1 No No
5 empty 2.06 57.1 12.6 No No
6 empty 2.01 60.7 14 No No
7 empty 1.91 53.7 11.6 No No
8 empty 2.5 65.5 12.8 No No
9 empty 1.94 61 14.3 No No
10 empty 1.99 53.9 14.2 No No
3IVH_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 72.5 32.3 Yes Yes
2 empty 2.21 70.3 39.6 No No
3 empty 2.38 67.5 21.2 No No
4 empty 2.15 56.6 21.6 No No
5 empty 2.51 63.3 19.6 No No
6 empty 2.27 66.5 20.6 No No
7 empty 2.44 64 24.2 No No
8 empty 2.19 59.9 16 No No
9 empty 2.07 69.2 13 No No
10 empty 2.11 60.6 13.5 No No
3IXJ_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.33 68.4 51.4 Yes Yes
2 empty 2.2 64.6 18 No No
3 empty 2.24 62.8 13.1 No No
4 empty 2.47 64.7 12.1 No No
5 empty 2.15 61.5 11.3 No No
6 empty 2.12 60.2 14.1 No No
7 empty 2.52 64.8 13.8 No No
8 empty 1.99 63.4 13.1 No No
9 empty 2 55.1 14.5 No No
10 empty 2.49 64.7 12.7 No No
2OHS_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 68.6 36.6 Yes Yes
2 empty 2.12 62.5 36 No No
3 empty 2.11 62.2 19.6 No No
4 empty 1.94 60.3 20 No No
5 empty 2.4 64 19.5 No No
6 empty 2.28 56.8 16.9 No No
7 empty 2.41 69.2 15.5 No No
8 empty 2.25 64.2 11.4 No No
9 empty 2.28 55.6 15 No No
10 empty 2.6 67.6 11.5 No No
1XN2_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 69.4 54.6 Yes Yes
2 empty 2.54 68.7 23.7 No No
3 empty 2.16 58.2 22.1 No No
4 empty 2.09 65.2 17 No No
5 empty 2.61 59.7 16.5 No No
6 empty 2.26 66.5 11.4 No No
7 empty 1.82 67.9 15.8 No No
8 empty 2.15 66.8 16 No No
9 empty 2.19 70.6 12.6 No No
10 empty 2.14 65 12.6 No No
4ZSR_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 69.7 54.2 Yes Yes
2 empty 2.5 66 21 No No
3 empty 2.2 63.3 19.9 No No
4 empty 2.16 72.1 11.6 No No
5 empty 1.92 69.5 14.9 No No
6 empty 2.13 65.6 11.5 No No
7 empty 2.19 61.2 16.7 No No
8 empty 2.11 66.3 13.5 No No
9 empty 2.29 62 13.3 No No
10 empty 2.08 61.8 13.8 No No
4J1K_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 72.4 47.2 Yes Yes
2 empty 2.32 65.7 15.9 No No
3 empty 2.38 74.3 15.1 No No
4 empty 2.21 57.5 17.1 No No
5 empty 2.27 67.5 16.2 No No
6 empty 2.39 58.9 19.2 No No
7 empty 1.92 67.8 11.3 No No
8 empty 2.3 59.9 16 No No
9 empty 2.32 63.8 13.5 No No
10 empty 2.1 66.6 16.2 No No
3UQU_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.32 71.6 37.1 Yes Yes
2 empty 2.28 60.3 23.5 No No
3 empty 2.15 63.9 17.7 No No
4 empty 2.32 62.8 16.4 No No
5 empty 2 58.2 18.1 No No
6 empty 1.84 60.2 15.3 No No
7 empty 2.04 62.3 13.6 No No
8 empty 2.2 59.4 14.3 No No
9 bound 1.93 57.2 14.6 No No
10 empty 2.07 63.9 11.8 No No
4X7I_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 73.6 30.8 Yes No
2 bound 2.14 57.2 31.5 No No
3 empty 2.03 65.5 16.7 No No
4 empty 2.15 61.7 14 No No
5 empty 2.05 68.8 12.9 No No
6 empty 1.96 57.7 12.4 No No
7 empty 2.22 64.4 9.7 No No
8 empty 2.06 61.4 13.5 No No
9 empty 2.08 60.9 13.6 No No
10 empty 2.3 60.5 15.3 No No
1W51_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 73.3 48.3 Yes Yes
2 empty 2.64 63.3 29.4 No No
3 empty 2.32 68.1 13.5 No No
4 empty 2.19 61.2 17.6 No No
5 empty 2.18 64.6 13.6 No No
6 empty 2.26 57.9 18.5 No No
7 empty 2.16 61 14.1 No No
8 empty 2.47 67.9 14.6 No No
9 empty 2.26 65.5 13.3 No No
10 empty 2.04 66.5 11.4 No No
1YM4_C Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 72.4 38.4 Yes No
2 empty 2.13 72.7 31.7 No No
3 empty 2.26 63.4 19.8 No No
4 empty 2.28 65.2 16.7 No No
5 empty 2.51 61.1 24.3 No No
6 empty 2.33 61.6 19.1 No No
7 empty 1.99 66 13 No No
8 empty 2.14 63.7 12.1 No No
9 empty 2.11 66.9 17.7 No No
10 empty 2.67 71.1 13.1 No No
3L5D_A Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 58.5 35.3 Yes No
2 bound 1.94 66.1 29.8 No No
3 empty 2.14 58.6 20.8 No No
4 empty 2.27 65.2 12.8 No No
5 empty 1.93 56.1 12.3 No No
6 empty 1.94 62.2 12 No No
7 empty 2.12 68.4 11 No No
8 empty 1.94 58.2 13.3 No No
9 empty 1.96 65.3 9.5 No No
10 empty 2.3 66.5 14.2 No No
4FSL_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 72.1 51.3 Yes Yes
2 empty 2.52 66.1 27.3 No No
3 empty 2.15 63.4 16.9 No No
4 empty 2.09 63.2 20.5 No No
5 empty 2.08 62.9 17.2 No No
6 empty 2.33 68.9 14.9 No No
7 empty 2.19 60.2 16.2 No No
8 empty 2.08 67.7 10.6 No No
9 empty 2.07 64.8 11.8 No No
10 empty 2.31 66.7 16.9 No No
3BUG_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 71.2 44.1 Yes Yes
2 empty 2.2 63 18.7 No No
3 empty 2.26 65.4 15.6 No No
4 empty 1.96 66.9 12.3 No No
5 empty 2.32 61.6 14.5 No No
6 empty 2.34 67.6 10.1 No No
7 empty 2.17 60.9 14.4 No No
8 empty 2.44 65.8 17.9 No No
9 empty 2.19 63.9 16.7 No No
10 empty 2.41 73.2 7.7 No No
3RU1_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 69.8 47.1 Yes Yes
2 empty 2.28 69.2 15.2 No No
3 empty 2.23 63.5 15.2 No No
4 empty 2.23 61.3 17.5 No No
5 empty 2.62 60.8 13.3 No No
6 empty 2.19 67.1 17.4 No No
7 empty 2.15 64.1 12 No No
8 empty 2.15 63.8 17.8 No No
9 empty 2.45 67 11.9 No No
10 empty 2.08 61.4 12.8 No No
4R92_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 68.8 29.5 Yes Yes
2 empty 2.11 55.5 28.5 No No
3 empty 2.18 63.1 22.1 No No
4 empty 2.04 62.8 17.9 No No
5 empty 2.01 61.8 12.4 No No
6 empty 2.09 66.9 11.9 No No
7 empty 1.9 62.5 16.7 No No
8 empty 1.95 61.9 11.2 No No
9 empty 2.39 63.3 12.5 No No
10 empty 1.86 57 14.1 No No
2B8L_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.36 70.3 53.8 Yes Yes
2 empty 1.93 61.2 20.4 No No
3 empty 2.23 66.4 17.4 No No
4 empty 2.47 67 14 No No
5 empty 2.44 53.3 12.7 No No
6 empty 2.2 64.3 10 No No
7 empty 2.05 70.1 12.3 No No
8 empty 2.18 64.8 14 No No
9 empty 1.98 56.2 13.3 No No
10 empty 2.37 59.6 13.9 No No
4EWO_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 71.8 44 Yes Yes
2 empty 2.36 71.8 26.9 No No
3 empty 2.36 61.1 19 No No
4 empty 1.91 61.6 12.9 No No
5 empty 2.29 63.8 15.5 No No
6 empty 2.26 62.4 14.2 No No
7 empty 2.34 60 16.9 No No
8 empty 2.1 60.1 12.5 No No
9 empty 2.31 69 9.6 No No
10 empty 2.24 69 10.3 No No
2P83_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 67.3 41.8 Yes Yes
2 empty 2.12 65.7 23.8 No No
3 empty 1.94 59.6 15.1 No No
4 empty 2.19 65.4 19.6 No No
5 empty 1.99 64.1 14.6 No No
6 empty 1.97 56.3 16.4 No No
7 empty 2.01 66.9 11.1 No No
8 empty 2.25 62.8 15.2 No No
9 empty 1.82 62.5 10.4 No No
10 empty 2.42 66.5 12.1 No No
5KQF_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 70.1 43.7 Yes Yes
2 empty 1.97 60.1 22.9 No No
3 empty 2.31 65.3 15 No No
4 empty 2.1 64.2 11.7 No No
5 empty 2.44 64.2 13.3 No No
6 empty 2.07 61.4 11.7 No No
7 empty 2.38 65.1 12.3 No No
8 empty 2.43 71.9 12.8 No No
9 empty 2.27 64.3 12.2 No No
10 empty 1.79 74 8.9 No No
3UQR_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 72.5 53.5 Yes Yes
2 empty 2 58.1 24.1 No No
3 empty 2.08 65.9 15.7 No No
4 empty 2.4 66.8 17.7 No No
5 empty 2.01 61.5 11 No No
6 empty 2.43 66.9 12.2 No No
7 empty 1.93 64.6 11.7 No No
8 empty 2.35 63.1 15.7 No No
9 empty 2.35 62.8 16.6 No No
10 empty 1.9 60.6 14.4 No No
4J1F_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 72.2 37.9 Yes Yes
2 empty 1.98 66.1 31.7 No No
3 empty 2.52 67.7 20.2 No No
4 empty 2.4 67.5 13 No No
5 empty 2.49 57.4 21.1 No No
6 empty 2.5 60.6 23 No No
7 empty 2.11 65.4 14.2 No No
8 bound 2.29 61.6 21.1 No No
9 empty 2.16 72.3 10.7 No No
10 empty 2.11 63.1 12.7 No No
3BUH_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 72.1 53.5 Yes Yes
2 empty 2.32 65.4 26.5 No No
3 empty 2.31 64.4 20.8 No No
4 empty 2.36 62.5 23.7 No No
5 empty 2.1 59.2 14.4 No No
6 empty 2.43 67.8 15.9 No No
7 empty 2.04 63.5 12.5 No No
8 empty 2.01 62.2 13.3 No No
9 empty 2.34 59.9 17.5 No No
10 empty 2.06 69.8 10.2 No No
1XN2_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 70.4 54.3 Yes Yes
2 empty 2.63 65.5 24.2 No No
3 empty 2.22 67.3 17.7 No No
4 empty 2.03 56.7 17.5 No No
5 empty 2.19 60.8 15 No No
6 empty 2.43 60.2 15.3 No No
7 empty 1.86 71.3 12.8 No No
8 empty 2.1 65.2 18.9 No No
9 empty 2.29 57.5 15.7 No No
10 empty 2.01 69.9 10.9 No No
3IND_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 70.9 44.1 Yes Yes
2 empty 2.03 71.7 29 No No
3 empty 2.48 68 25.2 No No
4 empty 2.23 63.3 22.5 No No
5 empty 2.21 61.1 19 No No
6 empty 2.48 65.8 16.7 No No
7 empty 2.13 64.8 14.6 No No
8 empty 2.2 63.3 15.1 No No
9 empty 1.82 61.4 12.8 No No
10 empty 2.29 68.6 10.8 No No
3VG1_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 68.2 44.4 Yes Yes
2 empty 2.31 71.5 23.4 No No
3 empty 1.93 76.8 20.8 No No
4 empty 2.17 65.3 21.1 No No
5 empty 2.33 59.6 22.4 No No
6 empty 2.07 65.5 16.8 No No
7 empty 1.97 58.6 12.2 No No
8 empty 2.63 68.6 13.1 No No
9 empty 2.16 64.4 12 No No
10 empty 2.5 67.2 15.3 No No
5HD0_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 73.4 43.8 Yes Yes
2 empty 1.95 63.7 30.5 No No
3 empty 2.12 67.6 17.6 No No
4 empty 2.24 63.4 16 No No
5 empty 2.01 72 11.4 No No
6 empty 2.04 68.3 11.6 No No
7 empty 2.19 62.7 16.5 No No
8 empty 1.78 60.3 13.7 No No
9 empty 2.16 63.2 14.9 No No
10 empty 1.86 73.2 11.2 No No
3KYR_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.42 73.1 40.6 Yes Yes
2 empty 1.96 68 25.5 No No
3 empty 2.17 64.1 23.9 No No
4 empty 2.1 62.4 16.7 No No
5 empty 2.37 67.1 15 No No
6 empty 2.66 63.8 20.8 No No
7 empty 2.2 66 16.8 No No
8 empty 2.42 64.9 13.9 No No
9 empty 2.16 63.1 12.4 No No
10 empty 1.92 52.8 16.6 No No
4I12_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 66.6 56.8 Yes Yes
2 empty 2.39 70.5 25.9 No No
3 empty 2.12 58.1 22.5 No No
4 empty 2.17 60.9 15.4 No No
5 empty 2.06 61.3 12.4 No No
6 empty 2.2 69.8 13.9 No No
7 empty 2.16 62.1 17.6 No No
8 empty 2.04 60.5 12.7 No No
9 empty 2.32 69.3 13.3 No No
10 empty 2.33 53.4 11.8 No No
3K5F_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.34 68.5 52.1 Yes Yes
2 empty 2.14 63.7 24.6 No No
3 empty 2.16 62.5 17.7 No No
4 empty 2.49 67.5 22.5 No No
5 empty 2.21 62 18.7 No No
6 empty 2.6 69.8 12.8 No No
7 empty 2.28 58.3 20.3 No No
8 empty 2.47 64.1 9.4 No No
9 empty 2.13 58.2 11.8 No No
10 empty 1.73 55.8 14.2 No No
2Q15_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 71.8 45.8 Yes Yes
2 empty 2.26 66.1 14.2 No No
3 empty 2.22 61.6 18.3 No No
4 empty 2.27 62.8 16.9 No No
5 empty 2.17 65.8 11.5 No No
6 empty 2.2 67.3 15.3 No No
7 empty 2.19 63.7 11.9 No No
8 empty 2.05 68.7 15 No No
9 empty 1.8 67.2 12.1 No No
10 empty 1.94 62.8 18.8 No No
2OHQ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 69.9 50.2 Yes Yes
2 empty 2.28 61.2 24.2 No No
3 empty 2.45 67.1 15.4 No No
4 empty 2.24 57.7 22.5 No No
5 empty 2.51 65.4 16.4 No No
6 empty 2.59 71.5 16.9 No No
7 empty 2.01 59.1 15.2 No No
8 empty 2.09 64.6 13.7 No No
9 bound 2.21 67.3 15.4 No No
10 empty 2.11 56.4 15 No No
3IVI_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 69.7 53.9 Yes Yes
2 empty 2.29 63.9 17.8 No No
3 empty 2.41 64.9 16.6 No No
4 empty 2.35 62 18.8 No No
5 empty 2.28 68.3 12.4 No No
6 empty 2.14 68.5 12.1 No No
7 empty 2.01 64.7 11.4 No No
8 empty 2.15 71.8 12.5 No No
9 empty 2.52 64.1 12.2 No No
10 empty 2.36 65.5 11.1 No No
4LXK_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 70.7 54 Yes Yes
2 empty 2.07 58.5 19.5 No No
3 empty 2.21 72.5 14.7 No No
4 empty 2.27 63.6 14.2 No No
5 empty 2.31 67 14.4 No No
6 empty 2.41 63.4 13.6 No No
7 empty 2.49 60.6 14.7 No No
8 empty 2.43 70.2 10.9 No No
9 empty 2.08 68.4 10.6 No No
10 empty 2.14 69.8 10.1 No No
3I25_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 72.1 41.8 Yes Yes
2 empty 2.41 67.1 31.8 No No
3 empty 2.19 56 22.5 No No
4 empty 2.19 66.1 13.3 No No
5 empty 2.23 63.5 14.3 No No
6 empty 2.18 64.1 10.1 No No
7 empty 2.19 55.8 16.1 No No
8 empty 2.29 65.4 12.7 No No
9 empty 2.3 61.6 15.4 No No
10 empty 2.68 63.4 11.4 No No
4DUS_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.26 70.6 43.8 Yes Yes
2 empty 2.3 61.7 28.1 No No
3 empty 2.26 69.6 16.7 No No
4 empty 2.16 67.7 18.2 No No
5 empty 2.34 59.8 16.1 No No
6 empty 2.44 66.9 16 No No
7 empty 2.35 61.5 14.4 No No
8 empty 1.99 67.3 11.8 No No
9 empty 2.33 69.2 15.1 No No
10 empty 1.94 67.9 13 No No
5MCQ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 72.3 41.2 Yes Yes
2 empty 2.14 71.8 29.1 No No
3 empty 2.25 66.5 20 No No
4 empty 2.21 65.9 19.1 No No
5 empty 2.28 63.3 16.7 No No
6 empty 2.06 67.6 14 No No
7 empty 2.02 60.6 13.3 No No
8 empty 2.57 67.2 11.7 No No
9 empty 2.15 58.9 15.1 No No
10 empty 1.94 61.6 12.1 No No
3HVG_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 72.5 38 Yes Yes
2 empty 2.1 60.5 30.2 No No
3 empty 2.12 63.1 20.2 No No
4 empty 2.2 62.4 19.1 No No
5 empty 1.95 59.4 14.5 No No
6 empty 2.19 63.7 17.3 No No
7 empty 2.34 66.8 12.2 No No
8 empty 2.41 65.7 12 No No
9 empty 2.06 74.4 8.1 No No
10 empty 2.2 63.5 10.9 No No
4R5N_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 67.6 64 Yes Yes
2 empty 2.16 58.3 21.6 No No
3 empty 2.22 67.6 16.5 No No
4 empty 1.82 62.8 20.4 No No
5 empty 2.22 59.5 19.3 No No
6 empty 2.01 63.9 12.2 No No
7 empty 2.08 60.8 15.9 No No
8 empty 2.38 61.9 14.2 No No
9 empty 2.35 66.8 14.1 No No
10 empty 2.53 70.1 12.4 No No
3K5G_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.45 69 49.7 Yes Yes
2 empty 1.98 60.6 19.1 No No
3 empty 2.21 64.3 18 No No
4 empty 2.33 61.3 15.5 No No
5 empty 2.07 67.9 13.8 No No
6 empty 2.27 68.6 13.3 No No
7 empty 2.6 67.3 10.3 No No
8 empty 2.19 53.9 15 No No
9 empty 2.08 58.2 14.5 No No
10 empty 2.5 70.3 13.6 No No
5HE4_B Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 70.3 50 Yes Yes
2 empty 2.22 61.4 38.4 No No
3 empty 2.3 65.6 20.9 No No
4 empty 2.13 73.8 11.9 No No
5 empty 2.02 67 12.1 No No
6 empty 2.46 63.3 15.9 No No
7 empty 1.98 66 10.8 No No
8 empty 2.06 68.9 15.9 No No
9 empty 1.97 72.1 14.7 No No
10 empty 2.18 67.2 12.2 No No
4IVS_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 70 41.2 Yes Yes
2 empty 2.19 69.1 27.3 No No
3 empty 2.15 68.1 20.1 No No
4 empty 2.47 68.1 29.4 No No
5 empty 2.38 65.4 16.7 No No
6 empty 1.95 68 16.6 No No
7 empty 2.02 68.9 13.9 No No
8 empty 2.17 61 12.3 No No
9 empty 2.16 66.7 14.8 No No
10 empty 2.02 62.1 12.7 No No
3DM6_B Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 63.5 31.6 Yes No
2 bound 2.41 75.8 27.4 No No
3 empty 2.02 64.2 18.7 No No
4 empty 1.92 55.2 12.9 No No
5 empty 1.83 64.2 11 No No
6 empty 2.22 66.5 14.4 No No
7 empty 2.15 68.4 12.1 No No
8 empty 2.49 56.4 12.4 No No
9 empty 2.14 63.8 10.9 No No
10 empty 2.15 64.7 9.9 No No
2F3E_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 70.7 53.9 Yes Yes
2 empty 2.08 64 22 No No
3 empty 2.07 61 18.4 No No
4 empty 2.26 68.7 15 No No
5 empty 2.26 61.8 15.6 No No
6 empty 2.06 67.7 12.1 No No
7 empty 2.49 64.7 10.7 No No
8 empty 2.45 69.3 11.9 No No
9 empty 2.45 69.9 12.9 No No
10 empty 2.35 68.4 9.9 No No
3U6A_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 69.7 50.5 Yes Yes
2 bound 2.3 60 30.6 No No
3 empty 2.11 64.1 15.1 No No
4 empty 2.2 62.5 16.2 No No
5 empty 2.28 67 17.9 No No
6 empty 1.86 55.8 14.1 No No
7 empty 2.5 70.2 15.2 No No
8 empty 2.17 64.3 11.8 No No
9 empty 2.42 64.2 12.9 No No
10 empty 2.41 67.5 12.1 No No
4B05_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 70.9 49.1 Yes Yes
2 empty 2.2 64.6 17.2 No No
3 bound 2.24 58.1 18.9 No No
4 empty 2.08 61.8 13.9 No No
5 empty 2.19 65.2 15.5 No No
6 empty 2.37 72.5 14 No No
7 empty 1.96 60.4 13.8 No No
8 empty 2.11 66.2 13 No No
9 empty 2.22 61.1 11.1 No No
10 empty 2.31 61 14.1 No No
3LPI_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 70.9 54.3 Yes Yes
2 empty 2.24 66.3 20.6 No No
3 empty 2.21 59.4 20.4 No No
4 empty 2.57 70 13.2 No No
5 empty 2.07 70.9 11.6 No No
6 empty 2.11 63.6 14.8 No No
7 empty 1.89 68.3 17.5 No No
8 empty 2.03 65.7 10.8 No No
9 empty 2.04 62.1 11.6 No No
10 empty 2.2 59.1 11.2 No No
4HA5_B Beta-secretase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 65.2 45.6 Yes No
2 empty 2.17 59.9 29.3 No No
3 empty 2.17 64 19.5 No No
4 empty 2.23 57 14.3 No No
5 empty 2.07 61.3 13.3 No No
6 empty 1.97 63.9 11.3 No No
7 empty 1.95 69.5 11 No No
8 empty 1.86 61.7 16.2 No No
9 empty 2.48 65.5 13.7 No No
10 empty 2.13 58.2 10.9 No No
5DQC_C Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.37 71 54.2 Yes Yes
2 empty 2.22 55.9 22.2 No No
3 empty 2.26 57 15 No No
4 empty 2.42 67.5 12 No No
5 empty 2.37 59 14.5 No No
6 empty 2.14 68.1 13 No No
7 empty 2.19 65.5 12.7 No No
8 empty 2.1 62.4 15.2 No No
9 empty 2.49 77.3 9.2 No No
10 empty 2.09 65 11 No No
3UDQ_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 69.4 63.4 Yes Yes
2 empty 2.2 61.6 20.7 No No
3 empty 2.28 72.4 16.7 No No
4 empty 2.3 71.3 12.2 No No
5 empty 1.95 62.9 22.4 No No
6 empty 2.12 60.5 16.9 No No
7 empty 2.16 63.3 11.4 No No
8 empty 2.03 64.6 12.3 No No
9 empty 2.23 70.8 15.6 No No
10 empty 2.55 70.1 14.8 No No
4ZPE_A Beta-secretase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 71.5 45.9 Yes Yes
2 empty 2.09 59.8 22.4 No No
3 empty 2.48 66.3 18 No No
4 empty 2.5 70.2 13.8 No No
5 empty 2.34 59 16.4 No No
6 empty 2.27 59.6 15.7 No No
7 empty 2.02 67.4 8.7 No No
8 empty 2.03 60.6