Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AVR4,AVR5 (P56734) - Overview - Molecular Target Synopsis

Protein


AVR4,AVR5, Avidin-related protein 4/5
UniProt P56734

Also Known as AVR4_CHICK, AVR4,AVR5


2MF6
SOLUTION NMR STRUCTURE OF CHIMERIC AVIDIN, CHIAVD(I117Y), IN THE BIOTIN BOUND FORM
RCSB/PDB
Inspect Structure
See all 3D Structures for AVR4,AVR5

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
150P56734-1

Sub-cellular localization


UniProt: AVR4,AVR5 is active in the following subcellular-locations: secreted.
GO terms: AVR4,AVR5 is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AVR4,AVR5 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For AVR4,AVR5 there are:
12 structures (36 chains) solved
7 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

AVR4,AVR5 is solved in complex with the approved drug(s):

BTN/BIOTIN (1Y52_X, 1Y52_Y, 1Y55_X, 1Y55_Y, 4BCS_A, 4BCS_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AVR4,AVR5 has been screened with compounds ( bioactivities). (see details)