Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

mdm2 (P56273) - Overview - Molecular Target Synopsis

Protein


mdm2, E3 ubiquitin-protein ligase Mdm2
Enzyme Classification 2.3.2.27
UniProt P56273

Also Known as MDM2_XENLA, mdm2

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome.

4LWU
THE 1.14A CRYSTAL STRUCTURE OF HUMANIZED XENOPUS MDM2 WITH RO5499252
RCSB/PDB
Inspect Structure
See all 3D Structures for mdm2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
473P56273-1

Sub-cellular localization


UniProt: mdm2 is active in the following subcellular-locations: cytoplasm, nucleolus, nucleoplasm, nucleus.
GO terms: mdm2 is active in the following subcellular-locations: cytoplasm, nucleolus, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project mdm2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For mdm2 there are:
12 structures (16 chains) solved
11 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


mdm2 has been screened with compounds ( bioactivities). (see details)