Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MARS (P56192) - Overview - Molecular Target Synopsis


MARS, Methionine--tRNA ligase, cytoplasmic
Enzyme Classification
UniProt P56192

Also Known as SYMC_HUMAN, MARS

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971). Monomer (PubMed:11714285). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464, Ref.24, PubMed:26472928). Forms a linear complex that contains MARS, EEF1E1, EPRS and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: MARS is active in the following subcellular-locations: cytoplasm, cytosol, nucleolus, nucleus.
GO terms: MARS is active in the following subcellular-locations: aminoacyl-tRNA synthetase multienzyme complex, cytoplasm, cytosol, extracellular exosome, membrane, nucleolus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MARS has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: K_562, CCRF_CEM, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SJCRH30, SK-N-FI, NCI-H1792

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

3D Structures

For MARS there are:
7 structures (7 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

MARS has been screened with 97 compounds (177 bioactivities), 19 compounds have bioactivities that show binding affinity of <= 500nM (19 bioactivities). (see details)