Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

aroE (P56119) - Overview - Molecular Target Synopsis

Protein


aroE, Shikimate dehydrogenase (NADP(+))
Enzyme Classification 1.1.1.25
UniProt P56119

Also Known as AROE_HELPY, aroE

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). Homodimer.

4FSH
CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE (AROE) CLINICAL VARIANT V2356 FROM HELICOBACTER PYLORI IN COMPLEX WITH SHIKIMATE
RCSB/PDB
Inspect Structure
See all 3D Structures for aroE

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
263P56119-1

Sub-cellular localization


GO terms: aroE is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project aroE has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For aroE there are:
10 structures (18 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis