Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTX-1 (P55927) - Overview - Molecular Target Synopsis

Protein


PTX-1, Potassium channel toxin alpha-KTx 7.1
UniProt P55927

Also Known as KAX71_PANIM, PTX-1

Potent inhibitor of the A-type voltage-gated potassium channels. Most potent inhibitor of Kv1.2/KCNA2 channels. Reversibly block the Shaker B potassium-channels (Kv1.1 sub-family).

2PTA
PANDINUS TOXIN K-A (PITX-KA) FROM PANDINUS IMPERATOR, NMR, 20 STRUCTURES
RCSB/PDB
Inspect Structure
See all 3D Structures for PTX-1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
47P55927-1

Sub-cellular localization


UniProt: PTX-1 is active in the following subcellular-locations: secreted.
GO terms: PTX-1 is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PTX-1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For PTX-1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis