Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GEM (P55040) - Overview - Molecular Target Synopsis

Protein


GEM, GTP-binding protein GEM
UniProt P55040

Also Known as GEM_HUMAN, GEM, KIR

Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1.

2CJW
CRYSTAL STRUCTURE OF THE SMALL GTPASE GEM (GEMDNDCAM) IN COMPLEX TO MG.GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for GEM

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
296ENSG00000164949ENST00000297596, ENST00000396194ENSP00000297596, ENSP00000379497P55040-1
100ENSG00000164949ENST00000523433ENSP00000428258

Sub-cellular localization


UniProt: GEM is active in the following subcellular-locations: cell membrane.
GO terms: GEM is active in the following subcellular-locations: cytoplasmic side of plasma membrane, midbody, mitotic spindle, nucleus, plasma membrane, spindle midzone.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GEM has gain in 9 cell-lines, loss in 4 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, HS578T, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H1915, G44

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, AG445

(see details)

3D Structures


For GEM there are:
3 structures (5 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GEM has been screened with compounds ( bioactivities). (see details)