Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

soxC (P54998) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria6
Chains with at least one site assessed as druggable using the relaxed criteria8


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4JEK_G Dibenzothiophene desulfurization enzyme C Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 72.5 35.5 Yes Yes
2 empty 2.35 63.2 35.4 No No
3 empty 2.18 68.3 26.9 No No
4 empty 2.1 76.3 19.2 No No
5 empty 2.11 61 30.6 No No
6 empty 2.5 67.3 19.3 No No
7 empty 1.79 65.9 22.2 No No
8 empty 1.9 71.7 16.4 No No
9 empty 2.3 63 14.4 No No
10 empty 2.28 54.8 14 No No
4JEK_A Dibenzothiophene desulfurization enzyme C Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 70.9 41.6 Yes Yes
2 empty 2.36 64.9 35 No No
3 empty 2.21 68.3 25.7 No No
4 empty 1.98 70.9 19.4 No No
5 empty 2.16 62.8 26.5 No No
6 empty 2.53 66.2 32.6 No No
7 empty 2.31 60 13.7 No No
8 empty 2.38 59.8 14 No No
9 empty 1.86 69.8 14.1 No No
10 empty 1.71 61.1 14 No No
4JEK_H Dibenzothiophene desulfurization enzyme C Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 70.8 40.7 Yes Yes
2 empty 2.34 65 36.1 No No
3 empty 2.3 67.1 27.4 No No
4 empty 2.11 72.3 21.4 No No
5 empty 2.09 63.5 27.6 No No
6 empty 2.44 66 16.6 No No
7 empty 1.91 70.6 14.8 No No
8 empty 2.34 58.1 13.6 No No
9 empty 1.73 65.6 14.8 No No
10 empty 2.18 59.6 12.2 No No
4JEK_B Dibenzothiophene desulfurization enzyme C Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 71.7 34.4 Yes No
2 empty 2.32 66.7 33.8 No No
3 empty 2.32 67.8 31.6 No No
4 empty 1.94 70.6 20.8 No No
5 empty 2.52 65.5 33.9 No No
6 empty 1.92 64.6 22.4 No No
7 empty 2.2 61.2 20.2 No No
8 empty 1.93 67 16.7 No No
9 empty 1.85 61.8 18 No No
10 empty 2.28 60.6 10.1 No No
4JEK_D Dibenzothiophene desulfurization enzyme C Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 71.8 37.8 Yes No
2 empty 2.32 65.2 34 No No
3 empty 2.29 66.8 25.2 No No
4 empty 1.96 72.6 19.1 No No
5 empty 2.45 65.1 35.2 No No
6 empty 1.92 65 23.2 No No
7 empty 2.29 63.1 17.9 No No
8 empty 1.93 67.8 14.1 No No
9 empty 2.02 60.4 16.5 No No
10 empty 1.6 67.6 11.6 No No
4JEK_F Dibenzothiophene desulfurization enzyme C Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 70.8 38.6 Yes Yes
2 empty 2.37 66.1 36.6 No No
3 empty 2.19 69.4 26.1 No No
4 empty 2 70.9 19.4 No No
5 empty 2.08 64.3 28.2 No No
6 empty 2.59 67.3 34 No No
7 empty 1.9 68.7 17.1 No No
8 empty 2.52 61.5 13.1 No No
9 empty 2.32 61.4 12.6 No No
10 empty 1.51 66.4 12.7 No No
4JEK_E Dibenzothiophene desulfurization enzyme C Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 69.7 40 Yes Yes
2 empty 2.35 63.8 36.9 No No
3 empty 2.22 67 25.9 No No
4 empty 1.95 71.4 19.4 No No
5 empty 1.93 67.4 19.8 No No
6 empty 2.47 65.9 21.8 No No
7 empty 1.9 70 17.3 No No
8 empty 1.78 62 16.8 No No
9 empty 2.41 55.1 13.7 No No
10 empty 2.29 58.8 12.1 No No
4JEK_C Dibenzothiophene desulfurization enzyme C Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 72.2 41 Yes Yes
2 empty 2.38 64.3 35.5 No No
3 empty 2.19 66.6 25.3 No No
4 empty 2.15 74.4 20.4 No No
5 empty 2.07 62.3 30.2 No No
6 empty 2.39 66.4 24 No No
7 empty 1.92 72.5 15.6 No No
8 empty 1.97 65.6 16.8 No No
9 empty 1.75 64.1 14.2 No No
10 empty 2.36 59.3 13.7 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score