Molecular Target Synopsis
Overview
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Chemistry
Ligand Efficiency Plot
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mntR (P54512) - Overview - Molecular Target Synopsis

Protein


mntR, HTH-type transcriptional regulator MntR
UniProt P54512

Also Known as MNTR_BACSU, mntR, yqhN

Central regulator of manganese homeostasis that regulates the expression of both manganese uptake and efflux systems (PubMed:27748968, PubMed:10760146, PubMed:12950915). In the presence of high levels of manganese, it mediates repression of the manganese uptake systems MntH and MntABCD and activation of the efflux systems MneP and MneS. Binds with high affinity to the regulatory regions of its target genes (PubMed:27748968, PubMed:12950915). The manganese concentration required for activation of efflux is higher than that for repression of uptake (PubMed:27748968). Homodimer.

4HX8
STRUCTURE OF METAL-FREE MNTR MUTANT E11K
RCSB/PDB
Inspect Structure
See all 3D Structures for mntR

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
142P54512-1

Sub-cellular localization


UniProt: mntR is active in the following subcellular-locations: cytoplasm.
GO terms: mntR is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project mntR has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For mntR there are:
18 structures (36 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis