Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PNLIPRP2 (P54317) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria3


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2OXE_B Pancreatic lipase-related protein 2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 70.3 16 No No
2 empty 1.81 54.8 22.7 No No
3 empty 2.12 62.6 22.7 No No
4 empty 2.13 61.8 22.6 No No
5 empty 2.11 58 21.2 No No
6 bound 2.06 57.8 15.4 No No
7 empty 2.07 59.1 18.9 No No
8 empty 2.09 60.2 13.6 No No
9 empty 2.33 65.8 11.7 No No
10 empty 1.32 55.6 13.4 No No
2PVS_B Pancreatic lipase-related protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 63.5 53 Yes No
2 empty 2.17 69 16.9 No No
3 empty 2.21 70.6 16.2 No No
4 empty 2.33 59.4 24.4 No No
5 empty 2.33 66.1 19.8 No No
6 empty 2.2 63.4 18.3 No No
7 empty 1.61 67.6 21.4 No No
8 empty 2.65 56.7 20.9 No No
9 empty 1.63 71.1 13.1 No No
10 empty 2.05 61.1 19 No No
2PVS_A Pancreatic lipase-related protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 62 33.9 Yes No
2 empty 2.28 61.4 40.7 No No
3 empty 2.18 69.3 16.7 No No
4 empty 2.11 69.9 17.5 No No
5 empty 1.91 60.6 18.8 No No
6 empty 2.17 66 22.3 No No
7 empty 2.23 70 14 No No
8 empty 2.37 66.2 12.3 No No
9 empty 2.71 71.3 14.7 No No
10 empty 1.46 70.1 13.1 No No
2OXE_A Pancreatic lipase-related protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.31 60.6 33.9 Yes No
2 empty 2.19 68.1 18.6 No No
3 empty 1.17 61 17.2 No No
4 empty 2.14 68.9 17 No No
5 empty 2.11 66.5 17.6 No No
6 empty 1.93 59 14 No No
7 empty 1.13 50.9 15 No No
8 empty 1.96 62.1 16.7 No No
9 empty 2.16 54.9 14.6 No No
10 empty 1.93 48.8 14.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed5
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria3

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2OXE_A (3170174) Pancreatic lipase-related protein 2 alpha/beta-Hydrolases, alpha/beta-Hydrolases, Pancreatic lipase N-terminal domain 2.8Å Yes No
2OXE_A (3170175) Pancreatic lipase-related protein 2 Lipase/lipooxygenase domain (PLAT/LH2 domain), Lipase/lipooxygenase domain (PLAT/LH2 domain), Colipase-binding domain 2.8Å No No
2PVS_B (4199884) Pancreatic lipase-related protein 2 alpha/beta-Hydrolases, alpha/beta-Hydrolases, Pancreatic lipase N-terminal domain 3Å Yes No
2PVS_A (3180258) Pancreatic lipase-related protein 2 Lipase/lipooxygenase domain (PLAT/LH2 domain), Lipase/lipooxygenase domain (PLAT/LH2 domain), Colipase-binding domain 3Å No No
2PVS_A (4199884) Pancreatic lipase-related protein 2 alpha/beta-Hydrolases, alpha/beta-Hydrolases, Pancreatic lipase N-terminal domain 3Å Yes No
2PVS_A (3180257) Pancreatic lipase-related protein 2 alpha/beta-Hydrolases, alpha/beta-Hydrolases, Pancreatic lipase N-terminal domain 3Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PNLIPRP2 is involved in 1 interactions in the network.


Druggability
Overall Druggability Percentile: 38.79
Druggability for Cancer Therapeutics: 28.73
Druggability for Other Therapeutics: 84.23
Cancer-Associated
Cancer-associated percentile : 18.92
Network Articulation Point
Is PNLIPRP2 critical for communication in the network?


Detailed Graph Legend:Help