Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PNLIPRP2 (P54317) - Overview - Molecular Target Synopsis

Protein


PNLIPRP2, Pancreatic lipase-related protein 2
Enzyme Classification 3.1.1.26
UniProt P54317

Also Known as LIPR2_HUMAN, PNLIPRP2, PLRP2

Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.

2PVS
STRUCTURE OF HUMAN PANCREATIC LIPASE RELATED PROTEIN 2 MUTANT N336Q
RCSB/PDB
Inspect Structure
See all 3D Structures for PNLIPRP2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
469P54317-1

Sub-cellular localization


UniProt: PNLIPRP2 is active in the following subcellular-locations: secreted.
GO terms: PNLIPRP2 is active in the following subcellular-locations: extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PNLIPRP2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LS1034, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For PNLIPRP2 there are:
2 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PNLIPRP2 has been screened with 4 compounds (17 bioactivities). (see details)