Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PNLIPRP1 (P54315) - Overview - Molecular Target Synopsis

Protein


PNLIPRP1, Inactive pancreatic lipase-related protein 1
UniProt P54315

Also Known as LIPR1_HUMAN, PNLIPRP1, PLRP1

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro).

2PPL
HUMAN PANCREATIC LIPASE-RELATED PROTEIN 1
RCSB/PDB
Inspect Structure
See all 3D Structures for PNLIPRP1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PNLIPRP1 is active in the following subcellular-locations: secreted.
GO terms: PNLIPRP1 is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PNLIPRP1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, SK_MEL_5, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For PNLIPRP1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PNLIPRP1 has been screened with compounds ( bioactivities). (see details)