Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC18A1 (P54219) - Overview - Molecular Target Synopsis

Protein


SLC18A1, Chromaffin granule amine transporter
UniProt P54219

Also Known as VMAT1_HUMAN, SLC18A1, VAT1, VMAT1

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.

Isoforms / Transcripts (Protein Coding)


Drugs


SLC18A1 is targeted by Approved Drug Lisdexamfetamine. (see details)
Lisdexamfetamine

Sub-cellular localization


UniProt: SLC18A1 is active in the following subcellular-locations: cytoplasmic vesicle, cytoplasmic vesicle membrane, endoplasmic reticulum membrane, secretory vesicle, synaptic vesicle membrane.
GO terms: SLC18A1 is active in the following subcellular-locations: cell junction, clathrin-sculpted monoamine transport vesicle membrane, endoplasmic reticulum membrane, integral component of membrane, synaptic vesicle membrane, terminal bouton.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC18A1 has gain in 0 cell-lines, loss in 11 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MHH-NB-11, KELLY, NCI-H810

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH_RA, SK-N-SH, NHLF

(see details)


Screening and Chemistry


SLC18A1 has been screened with 1 compounds (1 bioactivities). (see details)