Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC16A1 (P53985) - Overview - Molecular Target Synopsis

Protein


SLC16A1, Monocarboxylate transporter 1
UniProt P53985

Also Known as MOT1_HUMAN, SLC16A1, MCT1

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity). Interacts with BSG; this is required for expression at the cell membrane.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC16A1 is active in the following subcellular-locations: cell membrane.
GO terms: SLC16A1 is active in the following subcellular-locations: cell junction, centrosome, extracellular exosome, integral component of membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, membrane, plasma membrane, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC16A1 has gain in 3 cell-lines, loss in 3 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, SR, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: AGS, PA-1, G122

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HSMM, HeLa-S3

(see details)


Screening and Chemistry


SLC16A1 has been screened with 85 compounds (176 bioactivities), 61 compounds have bioactivities that show binding affinity of <= 500nM (142 bioactivities). (see details)