Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
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CBK1 (P53894) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed6
Chains with at least one site assessed as druggable using the strict criteria5
Chains with at least one site assessed as druggable using the relaxed criteria6


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4LQQ_A Serine/threonine-protein kinase CBK1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 77.4 56.9 Yes Yes
2 empty 1.87 67.9 44.8 No No
3 empty 2.13 65.1 22 No No
4 empty 2.49 66.1 31.2 No No
5 empty 2.21 59.6 24.3 No No
6 empty 2.15 60.5 24 No No
7 empty 1.79 60.9 17.6 No No
8 empty 2.14 72 14.4 No No
9 empty 1.85 73.8 14.6 No No
10 empty 1.95 51 15.3 No No
5NCL_A Serine/threonine-protein kinase CBK1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 74.6 45.3 Yes Yes
2 empty 2.43 68.2 34.6 No No
3 empty 2.04 59.8 24 No No
4 empty 2.4 62.9 22.9 No No
5 empty 2.69 61.5 17.4 No No
6 empty 2.22 65.5 20 No No
7 empty 2 71.6 14.8 No No
8 empty 2.39 86.1 16.8 Yes No
9 empty 2.11 62 13.8 No No
10 empty 2.41 68.9 12.6 No No
4LQQ_D Serine/threonine-protein kinase CBK1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 69.6 45.7 Yes Yes
2 empty 1.89 62.3 44.1 No No
3 empty 1.49 54.5 29.3 No No
4 empty 1.72 67.5 25 No No
5 empty 1.89 65.1 18.5 No No
6 empty 1.89 87.1 18.9 Yes No
7 empty 1.27 96 0 Yes No
8 empty 2.16 79.8 17.7 No No
9 empty 1.73 66.1 16.6 No No
10 empty 1.76 67.4 17.1 No No
4LQP_A Serine/threonine-protein kinase CBK1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 69.4 80.6 Yes Yes
2 empty 1.92 58.8 23.7 No No
3 empty 1.94 68.4 15.7 No No
4 empty 2.17 70.3 17.7 No No
5 empty 2.34 72.4 11.4 No No
6 empty 2.11 73.3 16.3 No No
7 empty 2.39 62.5 17.6 No No
8 empty 1.9 64.6 12.8 No No
9 empty 2.22 55.3 11.5 No No
10 empty 2.02 53.3 13.3 No No
4LQS_A Serine/threonine-protein kinase CBK1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 70.9 71.9 Yes Yes
2 empty 2.41 60.7 16.6 No No
3 empty 2.15 66.5 18.1 No No
4 empty 2.33 67.3 20.7 No No
5 empty 2.08 76.6 18.5 No No
6 empty 1.87 78.2 15.6 No No
7 empty 2.05 61.9 16 No No
8 empty 2.47 75.8 7.5 No No
9 empty 1.7 61.3 9.1 No No
10 empty 2.59 58 9.8 No No
5NCM_B Serine/threonine-protein kinase CBK1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 61.2 24.8 Yes No
2 empty 1.75 55.2 17.7 No No
3 empty 2.11 63.2 19.4 No No
4 empty 2.36 66.7 8.7 No No
5 empty 1.71 49.6 11.3 No No
6 empty 2.62 61.4 8.7 No No
7 empty 2.12 51.3 10.4 No No
8 empty 2.91 54.1 8.8 No No
9 empty 2.44 55.7 13.8 No No
10 empty 2.1 68.4 7 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score