Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RCAN1 (P53805) - Overview - Molecular Target Synopsis


RCAN1, Calcipressin-1
UniProt P53805

Also Known as RCAN1_HUMAN, RCAN1, ADAPT78, CSP1, DSC1, DSCR1

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). Interacts with RAF1 (PubMed:15935327). Interacts with PPP3CA and PPP3R1 (PubMed:12809556).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: RCAN1 is active in the following subcellular-locations: cytoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RCAN1 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SF_539, SN12C, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-24, WM-115, IPC-298

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, BJ, HSMM

(see details)

3D Structures

At greater than 75% identity similarity to RCAN1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis