Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MAPK10 (P53779) - Overview - Molecular Target Synopsis


MAPK10, Mitogen-activated protein kinase 10
Enzyme Classification
UniProt P53779

Also Known as MK10_HUMAN, MAPK10, JNK3, JNK3A, PRKM10, SAPK1B

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Interacts with MAPKBP1 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP1, MAPK8IP2/JIP2, MAPK8IP3/JIP3/JSAP1 and SPAG9/MAPK8IP4/JIP4. These proteins also bind other components of the JNK signaling pathway. Interacts with HDAC9. Interacts with ARRB2; the interaction enhances MAPK10 activation by MAP3K5. Interacts with SARM1.

Inspect Structure
See all 3D Structures for MAPK10

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: MAPK10 is active in the following subcellular-locations: cytoplasm, membrane, mitochondrion, nucleus.
GO terms: MAPK10 is active in the following subcellular-locations: cytoplasm, cytosol, glutamatergic synapse, mitochondrion, neuron projection, nucleoplasm, nucleus, perikaryon, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MAPK10 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: U251, SF_295, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RL, KARPAS-422, SU-DHL-4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, HMEC

(see details)

RNA Interference

MAPK10 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: PEO14, ASPC1. (see details)

3D Structures

For MAPK10 there are:
51 structures (60 chains) solved
47 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

MAPK10 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

MAPK10 has been screened with 1860 compounds (2407 bioactivities), 534 compounds have bioactivities that show binding affinity of <= 500nM (612 bioactivities). (see details)