Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GFA1 (P53704) - Overview - Molecular Target Synopsis

Protein


GFA1, Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Enzyme Classification 2.6.1.16
UniProt P53704

Also Known as GFA1_CANAL, GFA1

Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins). Homotetramer.

2POC
THE CRYSTAL STRUCTURE OF ISOMERASE DOMAIN OF GLUCOSAMINE-6-PHOSPHATE SYNTHASE FROM CANDIDA ALBICANS
RCSB/PDB
Inspect Structure
See all 3D Structures for GFA1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
713P53704-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project GFA1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For GFA1 there are:
4 structures (14 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GFA1 has been screened with compounds ( bioactivities). (see details)