Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

HST2 (P53686) - Overview - Molecular Target Synopsis


HST2, NAD-dependent protein deacetylase HST2
Enzyme Classification 3.5.1.-
UniProt P53686

Also Known as HST2_YEAST, HST2

NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export. Homotrimer. Monomer. Homotrimeric in its unliganded state. Undergoes a trimer-monomer transition upon acetyl-lysine substrate binding.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: HST2 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: HST2 is active in the following subcellular-locations: cytoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project HST2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures

For HST2 there are:
10 structures (12 chains) solved
9 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

HST2 has been screened with 57 compounds (97 bioactivities). (see details)