Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LIMK2 (P53671) - Overview - Molecular Target Synopsis

Protein


LIMK2, LIM domain kinase 2
Enzyme Classification 2.7.11.1
UniProt P53671

Also Known as LIMK2_HUMAN, LIMK2

Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Binds ROCK1 and MARF1 (Ref.9, PubMed:11018042, PubMed:10436159). Interacts with PARD3. Interacts with NISCH.

5NXD
LIM DOMAIN KINASE 2 (LIMK2) IN COMPLEX WITH TH-300
RCSB/PDB
Inspect Structure
See all 3D Structures for LIMK2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LIMK2 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: LIMK2 is active in the following subcellular-locations: cis-Golgi network, cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LIMK2 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, T47D, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OvCA 432, HCC2688, SU-DHL-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHEK, HMEC

(see details)

RNA Interference


LIMK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CASKI, CAL51. (see details)

3D Structures


For LIMK2 there are:
3 structures (5 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LIMK2 has been screened with 335 compounds (386 bioactivities), 173 compounds have bioactivities that show binding affinity of <= 500nM (180 bioactivities). (see details)