Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MVD (P53602) - Overview - Molecular Target Synopsis

Protein


MVD, Diphosphomevalonate decarboxylase
Enzyme Classification 4.1.1.33
UniProt P53602

Also Known as MVD1_HUMAN, MVD, MPD

Performs the first committed step in the biosynthesis of isoprenes. Homodimer.

3D4J
CRYSTAL STRUCTURE OF HUMAN MEVALONATE DIPHOSPHATE DECARBOXYLASE
RCSB/PDB
Inspect Structure
See all 3D Structures for MVD

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: MVD is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MVD has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, HCC_2998, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LCLC-103H, HuH-7, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HMEC, SK-N-SH

(see details)

3D Structures


For MVD there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MVD has been screened with 6 compounds (7 bioactivities), 5 compounds have bioactivities that show binding affinity of <= 500nM (5 bioactivities). (see details)