Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SUCLG2 (P53590) - Overview - Molecular Target Synopsis

Protein


SUCLG2, Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
Enzyme Classification 6.2.1.4
UniProt P53590

Also Known as SUCB2_PIG, SUCLG2

GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.

5CAE
SUCCINATE BOUND TO PIG GTP-SPECIFIC SUCCINYL-COA SYNTHETASE
RCSB/PDB
Inspect Structure
See all 3D Structures for SUCLG2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
433P53590-1

Sub-cellular localization


UniProt: SUCLG2 is active in the following subcellular-locations: mitochondrion.
GO terms: SUCLG2 is active in the following subcellular-locations: mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SUCLG2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For SUCLG2 there are:
8 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis