Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
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Gene Copy Number Variation
RNAi
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Germline Genetics

METAP1 (P53582) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed34
Chains with at least one site assessed as druggable using the strict criteria14
Chains with at least one site assessed as druggable using the relaxed criteria34


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4IKT_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 72.2 28.5 Yes No
2 empty 2.23 63.2 31 No No
3 empty 2.14 64.8 20.6 No No
4 empty 2.08 70.4 25.6 No No
5 empty 2.28 68.7 18.3 No No
6 empty 2.27 55.5 19.4 No No
7 empty 1.85 67.6 13.3 No No
8 empty 2.45 53.3 17.3 No No
9 empty 1.57 61.9 15.8 No No
10 empty 2.49 67.8 16.1 No No
4U75_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 73.8 32.8 Yes Yes
2 empty 2.1 62.4 16.9 No No
3 empty 2.08 65.1 22.8 No No
4 empty 2.14 71.7 23.9 No No
5 empty 2.25 65.6 18.4 No No
6 empty 1.99 68.9 13.5 No No
7 empty 2.33 63.2 19.9 No No
8 empty 2.04 56.2 13.4 No No
9 empty 2.36 63 10.2 No No
10 empty 2.4 77 7.8 No No
2B3H_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 73.7 31.7 Yes No
2 empty 2.24 66.2 23.7 No No
3 empty 2.04 63.9 17.8 No No
4 empty 2.18 72 16.2 No No
5 empty 2.05 69.5 16.9 No No
6 empty 1.87 68.7 12.6 No No
7 empty 2.49 55.9 17.7 No No
8 empty 1.99 57.7 12.2 No No
9 empty 2.29 75.9 8.3 No No
10 empty 2.08 67.5 12.4 No No
4U73_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 71 33.1 Yes Yes
2 empty 2.09 66.2 22.7 No No
3 empty 1.97 69.9 29.2 No No
4 empty 2.08 65 19.4 No No
5 empty 2.31 65.1 17.2 No No
6 empty 1.93 66.3 12.4 No No
7 empty 2.21 53.8 18.8 No No
8 empty 2.62 55 14.2 No No
9 empty 2.65 72.6 15.4 No No
10 empty 2.16 64.8 12.8 No No
4U6W_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 72.5 33.4 Yes Yes
2 empty 2.02 64.9 17.3 No No
3 empty 1.86 70.4 26.9 No No
4 empty 2.09 66.6 18.2 No No
5 empty 2.22 68.3 19.5 No No
6 empty 1.94 68.2 14.3 No No
7 empty 2.15 59 15.6 No No
8 empty 2.44 72.7 16.4 No No
9 empty 2.38 64.2 15.1 No No
10 empty 2.49 60.5 12.8 No No
2B3K_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 70.1 32.9 Yes Yes
2 empty 2.17 67.8 16 No No
3 empty 2.15 61.8 19 No No
4 empty 2.08 69.7 23 No No
5 empty 2.1 70.2 17.6 No No
6 empty 1.89 67.7 15.4 No No
7 empty 2.6 51.9 18.2 No No
8 empty 2.12 55.9 10.7 No No
9 empty 2.2 70 16.2 No No
10 empty 2.48 63.3 11.8 No No
5YR7_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 69.4 34.9 Yes No
2 empty 2.22 67.2 17.5 No No
3 empty 2.15 71.3 16.4 No No
4 empty 2.02 70.4 28.5 No No
5 empty 2.19 67.9 19.6 No No
6 empty 1.91 69.3 14.1 No No
7 empty 2.5 57.1 13.3 No No
8 empty 2.09 53.1 13.9 No No
9 empty 2.41 76.7 14.9 No No
10 empty 2.28 60 11.1 No No
2G6P_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 70.5 33.8 Yes Yes
2 empty 2.29 65.9 27.9 No No
3 empty 2.35 67.5 31.4 No No
4 empty 2.19 70 16.1 No No
5 empty 2.43 63.9 18.2 No No
6 empty 1.96 71.1 11.3 No No
7 empty 2.48 51.1 17.2 No No
8 empty 2.18 53.8 15.1 No No
9 empty 2.27 75.3 12.6 No No
10 empty 2.21 66.7 12.7 No No
5YR5_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 72.6 42.6 Yes Yes
2 empty 2.07 62.3 19.7 No No
3 empty 2.2 66.7 18.9 No No
4 empty 2.42 61.2 24.8 No No
5 empty 2.23 68.9 15.1 No No
6 empty 1.97 64.3 14 No No
7 empty 2.25 57.8 20.2 No No
8 empty 2.25 65.1 13.3 No No
9 empty 2.37 78.3 7.3 No No
10 empty 1.18 99.6 0 Yes No
4U76_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 73.1 32 Yes Yes
2 empty 2.29 61.3 30.1 No No
3 empty 1.93 71.7 26.3 No No
4 empty 2.15 64.9 18 No No
5 empty 2.19 72 18.3 No No
6 empty 2 64 13.6 No No
7 empty 1.97 59.1 11.7 No No
8 empty 2.3 76.1 11.1 No No
9 empty 2.13 58.1 14.3 No No
10 bound 1.28 99.6 0 Yes No
4IU6_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 74.8 23.1 Yes No
2 empty 2.27 65.6 27.6 No No
3 bound 2.15 68.1 16.3 No No
4 empty 2.52 69.3 29.8 No No
5 empty 2.28 60.9 27.7 No No
6 empty 1.93 69 14.3 No No
7 empty 2.47 57.9 16.3 No No
8 empty 1.53 59.9 15.1 No No
9 empty 2.03 54.9 10.7 No No
10 empty 2.3 55.3 18.8 No No
4IKU_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 70.5 29.9 Yes No
2 empty 2.3 63.3 26.1 No No
3 empty 2.17 63.5 16.6 No No
4 empty 2.55 69 28.7 No No
5 empty 2.32 66.7 16.1 No No
6 empty 2.58 52 17.9 No No
7 empty 1.87 70.9 11.7 No No
8 empty 2.26 53 21.3 No No
9 empty 2.65 72.8 15.4 No No
10 empty 1.58 58.6 14.5 No No
2B3L_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 75.1 31.2 Yes Yes
2 empty 2.31 63.2 27.3 No No
3 empty 2.12 68.9 19.5 No No
4 empty 1.94 66.9 17.2 No No
5 empty 1.9 68 12.1 No No
6 empty 2.18 70.4 14 No No
7 empty 2.59 56.1 13.5 No No
8 empty 2.77 68.5 18 No No
9 empty 2.08 56.5 14.5 No No
10 empty 2.05 66.6 14.5 No No
4U6Z_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 75 31.9 Yes Yes
2 empty 2.15 68.4 18.5 No No
3 empty 2.15 71.1 25.1 No No
4 empty 2.1 65.3 16.4 No No
5 empty 2.19 66.8 18.9 No No
6 empty 1.87 69.2 12.6 No No
7 empty 2.53 55.3 17.3 No No
8 empty 2.76 70.4 24 No No
9 empty 2.05 53.4 12.8 No No
10 empty 2.11 65.5 12.8 No No
4U6E_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 68.8 35.7 Yes No
2 empty 2.09 60.2 21.8 No No
3 empty 2.18 69 20.2 No No
4 empty 2.14 73.5 15.4 No No
5 empty 2.34 65 17.9 No No
6 empty 2.6 53.7 15.5 No No
7 empty 2.24 55.4 19.8 No No
8 empty 1.97 66.4 12.8 No No
9 empty 2.33 76.5 8.1 No No
10 empty 2.51 56.5 17.5 No No
4U69_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 74.3 22.8 Yes No
2 empty 2.15 69.9 15.9 No No
3 empty 2.06 65.8 20.2 No No
4 empty 2.16 71 29.8 No No
5 empty 2.13 67 19.5 No No
6 empty 2.36 56.9 24.6 No No
7 empty 1.96 67.3 11.8 No No
8 empty 2.47 55.4 17.3 No No
9 empty 1.48 58.2 15.8 No No
10 empty 2.44 72.2 16.3 No No
4U1B_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 75.4 28.2 Yes No
2 empty 2.09 64.9 15.7 No No
3 empty 1.95 69.6 28.3 No No
4 empty 2.12 64.8 19.1 No No
5 empty 2.47 52.2 16.1 No No
6 empty 1.97 64 18.5 No No
7 empty 1.96 67 12.2 No No
8 empty 1.46 62 15.5 No No
9 empty 2.11 58.3 12.8 No No
10 empty 2.3 72.3 15 No No
4FLK_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 72.8 31 Yes No
2 empty 2.1 65 23 No No
3 empty 2.01 66.3 19.9 No No
4 empty 2.04 70 17.5 No No
5 empty 1.99 72.7 20.3 No No
6 empty 1.91 67.7 15.3 No No
7 empty 1.99 56 11.3 No No
8 empty 2.26 55.3 14.3 No No
9 empty 2.38 77.5 12.7 No No
10 empty 2.16 66 10.7 No No
5YR6_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 73.6 33.2 Yes Yes
2 empty 2.09 65.4 22.2 No No
3 empty 2.02 68.1 24.2 No No
4 empty 2.15 65.6 21.5 No No
5 empty 2.21 67.5 20 No No
6 empty 2.02 67.1 12.9 No No
7 empty 2.27 53.1 19.6 No No
8 empty 2.54 58.6 18.1 No No
9 empty 2.38 65.2 15.2 No No
10 empty 2.37 74.5 13.1 No No
4HXX_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 77.6 16 Yes No
2 empty 2.3 64 30.5 No No
3 bound 2.13 66.2 17.4 No No
4 empty 2.13 71.2 28.6 No No
5 empty 2.42 53.8 25.6 No No
6 empty 2.33 63.5 18.9 No No
7 empty 2.35 57.8 18.8 No No
8 empty 1.94 67.3 12.7 No No
9 empty 2.61 55.1 15.3 No No
10 empty 1.58 57.4 15.5 No No
2NQ6_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 70.2 33 Yes No
2 empty 2.18 68 16.9 No No
3 empty 2.47 69.3 29.1 No No
4 empty 2.27 63.2 19.2 No No
5 empty 2.35 62.7 19 No No
6 empty 1.91 69.8 12 No No
7 empty 2.46 53.5 16.3 No No
8 empty 2.7 73.2 18.3 No No
9 empty 2.05 56.2 12.2 No No
10 empty 2.26 58.7 16.7 No No
2NQ7_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 74 28.8 Yes No
2 empty 2.17 64.8 16.6 No No
3 empty 2.14 70.6 27.5 No No
4 empty 2.17 67 16.9 No No
5 empty 2.25 68.1 15 No No
6 empty 1.93 64.3 13.5 No No
7 empty 2.5 53.8 17.2 No No
8 empty 2.31 55.8 18.7 No No
9 empty 2.73 72.1 13.9 No No
10 empty 1.51 57.1 15.9 No No
4U71_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 72.3 31.1 Yes No
2 empty 2.17 63.2 24.7 No No
3 empty 2.11 64.3 22.4 No No
4 empty 2.2 71.9 23.8 No No
5 empty 2.39 66.4 17.9 No No
6 empty 1.95 67.9 11.9 No No
7 empty 2.67 52.8 18.5 No No
8 empty 1.99 56.8 13.3 No No
9 empty 2.41 79.2 8.2 No No
10 empty 2.18 62.3 11.7 No No
5YKP_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 74.5 32.4 Yes Yes
2 empty 2.38 68.6 25.3 No No
3 empty 2.07 61.2 17.2 No No
4 empty 1.78 70.7 27.2 No No
5 empty 1.97 64.5 15.1 No No
6 empty 2.22 58.9 17.4 No No
7 empty 2.03 57.3 14.5 No No
8 empty 2.27 71.8 16.5 No No
9 empty 2.35 67.1 12.5 No No
10 empty 1.38 99.6 0 Yes No
4FLJ_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 73 35.7 Yes Yes
2 empty 2.09 65.9 20.1 No No
3 empty 2.08 65.2 17.5 No No
4 empty 2.16 68.6 16.8 No No
5 empty 2.19 63.4 19.4 No No
6 empty 1.91 68.5 11.4 No No
7 empty 1.97 53.3 10.9 No No
8 empty 2.23 74.7 13.8 No No
9 empty 2.24 64.5 14.7 No No
10 empty 2.48 60.1 12.7 No No
4U6J_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 71 31.8 Yes No
2 empty 2.05 66.7 17.8 No No
3 empty 2.17 71 21.3 No No
4 empty 2.27 71.4 26.9 No No
5 empty 2.27 67.2 16.5 No No
6 empty 1.88 64.7 12.7 No No
7 empty 2.61 54.7 15.1 No No
8 empty 2 55.9 16 No No
9 empty 2.72 72.5 18.7 No No
10 empty 2.25 58.1 14.2 No No
4FLL_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 77.9 16.4 Yes No
2 empty 2.08 67.4 20.9 No No
3 empty 2 64.2 16.2 No No
4 empty 1.9 69.7 16.7 No No
5 empty 1.95 73.7 18.9 No No
6 empty 2.57 68.2 23.9 No No
7 empty 2.17 53.6 19.5 No No
8 empty 1.93 67.1 12.7 No No
9 empty 2.18 56.9 16.9 No No
10 empty 2.15 65.6 13.4 No No
4IKR_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 72.9 27.9 Yes No
2 empty 2.07 67.3 16 No No
3 empty 2.24 70.5 27.9 No No
4 empty 2.18 63.9 21.9 No No
5 empty 2.29 67 16.1 No No
6 empty 2.49 56.3 21.4 No No
7 empty 1.94 69.3 13.2 No No
8 empty 2.21 63.1 17.7 No No
9 empty 2.49 52.3 16.9 No No
10 empty 1.56 59.9 15.9 No No
4U6C_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 74.4 31.4 Yes No
2 empty 2.11 67.5 15.5 No No
3 empty 2.05 70 26.3 No No
4 empty 2.14 64 19.5 No No
5 empty 2.27 67.6 18.9 No No
6 empty 1.89 66.6 12.6 No No
7 empty 2.53 53.8 17.5 No No
8 empty 2.01 52.3 15 No No
9 empty 2.46 72 16 No No
10 empty 2.29 61.8 10.2 No No
2GZ5_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 76.8 23 Yes No
2 empty 2.2 65.6 23.5 No No
3 empty 1.97 69.8 27.9 No No
4 empty 2.13 59.7 22.7 No No
5 empty 2.06 71.1 16.7 No No
6 empty 1.93 69.9 12 No No
7 empty 2.49 53.4 15.1 No No
8 empty 2.05 58.8 12.3 No No
9 empty 2.39 56.6 16.6 No No
10 empty 2.26 76.6 11.9 No No
4U70_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 73.2 32.9 Yes Yes
2 empty 2.17 69.8 16.1 No No
3 empty 2.13 64.8 16.8 No No
4 empty 2.31 65.2 16 No No
5 empty 1.93 65.3 12.8 No No
6 empty 2.82 70 23.7 No No
7 empty 2.5 54.6 14.6 No No
8 empty 1.96 55.1 14.8 No No
9 empty 1.59 60.7 16.1 No No
10 empty 2.28 56.2 12.6 No No
4IKS_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 70 30.3 Yes No
2 empty 2.31 66.2 28.8 No No
3 empty 2.27 62 33 No No
4 empty 2.08 64.4 15.8 No No
5 empty 2.06 70.3 27.1 No No
6 empty 1.84 65.7 13.1 No No
7 empty 2.48 49.3 17.5 No No
8 empty 2.21 57.5 14.3 No No
9 empty 1.48 55.6 16.1 No No
10 empty 2.21 73.8 14.6 No No
5YR4_A Methionine aminopeptidase 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 75.2 33.1 Yes Yes
2 empty 2.31 65 25.1 No No
3 empty 2.1 64.6 21.5 No No
4 empty 1.97 69.9 24.8 No No
5 empty 2.13 56.9 21.2 No No
6 empty 1.97 65.6 12.9 No No
7 empty 2.11 73 14.5 No No
8 empty 2.83 53.5 19 No No
9 empty 2.19 57.8 14.2 No No
10 empty 2.31 73.2 10.5 No No
4FLI_A Methionine aminopeptidase 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 76.4 23.1 Yes No
2 empty 2.09 64.1 16.1 No No
3 empty 2.07 66.4 18.8 No No
4 empty 2.08 67.1 17.5 No No
5 empty 2.39 56.3 22.8 No No
6 empty 2.02 73.2 18 No No
7 empty 1.91 67.9 15.3 No No
8 empty 2.56 60.7 19.6 No No
9 empty 2.2 67 12.4 No No
10 empty 2.31 56.2 13.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed10
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria8

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2B3H_A (3040849) Methionine aminopeptidase 1 Creatinase/aminopeptidase, Creatinase/aminopeptidase, UNMATCHED 1.1Å Yes No
2B3K_A (3040850) Methionine aminopeptidase 1 UNMATCHED, UNMATCHED, UNMATCHED 2B3K 1.55Å No No
2B3K_A (3040851) Methionine aminopeptidase 1 Creatinase/aminopeptidase, Creatinase/aminopeptidase, UNMATCHED 1.55Å Yes No
2B3L_A (3040853) Methionine aminopeptidase 1 Creatinase/aminopeptidase, Creatinase/aminopeptidase, UNMATCHED 1.5Å Yes No
2G6P_A (3090808) Methionine aminopeptidase 1 UNMATCHED, UNMATCHED, UNMATCHED 2G6P 1.77Å No No
2G6P_A (3090809) Methionine aminopeptidase 1 Creatinase/aminopeptidase, Creatinase/aminopeptidase, UNMATCHED 1.77Å Yes No
2GZ5_A (3100558) Methionine aminopeptidase 1 Creatinase/aminopeptidase, Creatinase/aminopeptidase, UNMATCHED 1.1Å Yes No
2NQ6_A (3150585) Methionine aminopeptidase 1 Creatinase/aminopeptidase, Creatinase/aminopeptidase, UNMATCHED 1.5Å Yes Yes
2NQ7_A (3150586) Methionine aminopeptidase 1 UNMATCHED, UNMATCHED, UNMATCHED 2NQ7 1.6Å Yes No
2NQ7_A (3150587) Methionine aminopeptidase 1 Creatinase/aminopeptidase, Creatinase/aminopeptidase, UNMATCHED 1.6Å Yes No
Ligand-based Druggability Score: -0.3
Ligand-based Druggability Score Percentile: 76%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


METAP1 is involved in 2 interactions in the network.


Druggability
Overall Druggability Percentile: 29.23
Druggability for Cancer Therapeutics: 17.41
Druggability for Other Therapeutics: 15.43
Cancer-Associated
Cancer-associated percentile : 46.83
Network Articulation Point
Is METAP1 critical for communication in the network?


Detailed Graph Legend:Help