Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

METAP1 (P53582) - Overview - Molecular Target Synopsis

Protein


METAP1, Methionine aminopeptidase 1
Enzyme Classification 3.4.11.18
UniProt P53582

Also Known as MAP11_HUMAN, METAP1, KIAA0094

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. Associates with the 60S ribosomal subunit of the 80S translational complex.

5YR7
HUMAN METHIONINE AMINOPEPTIDASE TYPE 1B (F309L MUTANT)
RCSB/PDB
Inspect Structure
See all 3D Structures for METAP1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: METAP1 is active in the following subcellular-locations: cytoplasm.
GO terms: METAP1 is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project METAP1 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, HL_60, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: ATRFLOX, HCT 116, CW-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, SK-N-SH

(see details)

3D Structures


For METAP1 there are:
34 structures (34 chains) solved
30 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

METAP1 is solved in complex with the approved drug(s):

MET/METHIONINE (4U6J_A, 4U75_A, 5YR7_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


METAP1 has been screened with 433 compounds (586 bioactivities), 44 compounds have bioactivities that show binding affinity of <= 500nM (47 bioactivities). (see details)