Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

bioK (P53555) - Overview - Molecular Target Synopsis

Protein


bioK, L-Lysine--8-amino-7-oxononanoate transaminase
Enzyme Classification 2.6.1.105
UniProt P53555

Also Known as BIOK_BACSU, bioK, bioA

Catalyzes the transfer of the alpha-amino group from L-lysine to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). B.subtilis is the only bacterium known to utilize L-lysine as an amino donor in the biosynthesis of DAPA. Homodimer.

3DOD
CRYSTAL STRUCTURE OF PLP BOUND 7,8-DIAMINOPELARGONIC ACID SYNTHASE IN BACILLUS SUBTILIS
RCSB/PDB
Inspect Structure
See all 3D Structures for bioK

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
448P53555-1

Sub-cellular localization


UniProt: bioK is active in the following subcellular-locations: cytoplasm.
GO terms: bioK is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project bioK has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For bioK there are:
3 structures (6 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis