Molecular Target Synopsis
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PNC1 (P53184) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed14
Chains with at least one site assessed as druggable using the strict criteria3
Chains with at least one site assessed as druggable using the relaxed criteria13


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3V8E_D Nicotinamidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.66 66.5 39.3 Yes Yes
2 empty 2.18 65.3 21.9 No No
3 empty 2.39 69.8 13.1 No No
4 empty 2.39 51 20.1 No No
5 empty 2.51 61.4 21.3 No No
6 empty 2.25 63.5 10.3 No No
7 empty 2.03 66.5 9.6 No No
8 empty 2.44 61.4 13.3 No No
9 empty 2.25 69.7 7.6 No No
10 empty 2.16 65.3 7.5 No No
2H0R_E Nicotinamidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 68.3 31.5 Yes Yes
2 empty 2.15 66.2 22.6 No No
3 empty 2.32 63.7 16.6 No No
4 empty 2.42 60.6 14 No No
5 empty 1.9 67.1 12.8 No No
6 empty 2.61 59.7 20.9 No No
7 empty 2.23 57.5 14.3 No No
8 empty 2.11 65.3 9.1 No No
9 empty 2.21 58.3 9.2 No No
10 empty 2.61 56.9 9.4 No No
3V8E_B Nicotinamidase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 66.5 36 Yes No
2 empty 2.08 60.4 24.2 No No
3 empty 2.31 66.3 19.1 No No
4 empty 2.53 61.8 16 No No
5 empty 2.31 68 13.3 No No
6 empty 1.94 71.1 9.5 No No
7 empty 2.81 59 13.5 No No
8 empty 1.97 67.5 9.6 No No
9 empty 2.25 66.3 8.1 No No
10 empty 2.14 67.8 8.9 No No
2H0R_F Nicotinamidase No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 69.9 20.7 No No
2 empty 1.94 62.3 29 No No
3 empty 2.19 62.1 21.9 No No
4 empty 2.2 63.9 16.4 No No
5 empty 2.53 62 22.3 No No
6 empty 1.73 68.2 10.8 No No
7 empty 2.25 52.2 13.7 No No
8 empty 2.31 61.3 13.2 No No
9 empty 2.57 68 7.1 No No
10 empty 2.24 73.9 8.2 No No
3V8E_C Nicotinamidase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 67.1 33.2 Yes No
2 empty 2.11 62.9 22.8 No No
3 empty 2.33 67.9 15.4 No No
4 empty 2.3 65.8 17.6 No No
5 empty 1.88 71.3 9.6 No No
6 empty 2.22 51.4 15.7 No No
7 empty 2.56 63.7 13.5 No No
8 empty 2.04 72.7 8.9 No No
9 empty 2.08 65 7.7 No No
10 empty 2.54 59.7 9.3 No No
2H0R_C Nicotinamidase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 66.8 31.1 Yes No
2 empty 2.12 63.3 20.8 No No
3 empty 2.4 56.7 16.7 No No
4 empty 2.43 64.6 17.6 No No
5 empty 2.42 57.1 14.7 No No
6 empty 2.38 68.1 13.9 No No
7 empty 1.99 71.2 10.3 No No
8 empty 2.61 64.3 15.1 No No
9 empty 1.93 68.7 8 No No
10 empty .81 100 0 Yes No
2H0R_G Nicotinamidase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 64.2 40.3 Yes No
2 empty 2.34 64.6 24 No No
3 empty 2.22 59.7 22.6 No No
4 empty 2.35 51.1 19.8 No No
5 empty 1.89 65.4 11.6 No No
6 empty 2.66 61.8 20.9 No No
7 empty 2.2 62.7 9.3 No No
8 empty .84 98.3 0 Yes No
9 empty 2.09 68.4 6.7 No No
10 empty 2.19 72.3 8.8 No No
3V8E_F Nicotinamidase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 65.6 36.7 Yes No
2 empty 2.24 62.2 21.9 No No
3 empty 2.12 67.4 14.7 No No
4 empty 2.1 57.4 13.5 No No
5 empty 2.29 60.5 11.8 No No
6 empty 2.81 65.1 11.2 No No
7 empty 2.15 73 9.9 No No
8 empty 2.01 74.1 9.3 No No
9 empty 2.35 61.6 12 No No
10 empty 2.15 66.1 6.8 No No
2H0R_B Nicotinamidase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 65.7 34.1 Yes No
2 empty 2.35 64.5 30.5 No No
3 empty 2.09 60.4 22.2 No No
4 empty 2.19 61.1 20 No No
5 empty 1.89 68.8 10.4 No No
6 empty 2.37 69.5 18.2 No No
7 empty 1.94 69.6 9.1 No No
8 empty 2.83 62.5 14.3 No No
9 empty 2.08 58.3 8.4 No No
10 empty .79 98.9 0 Yes No
3V8E_G Nicotinamidase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 67.4 40.2 Yes Yes
2 empty 2.11 61.8 21.7 No No
3 empty 2.37 69.2 14.6 No No
4 empty 2.44 62.7 16.1 No No
5 empty 2.22 52.9 13.8 No No
6 empty 2.27 65.4 8.6 No No
7 empty 2.72 64.8 10.9 No No
8 empty 2.3 63.9 8.5 No No
9 empty 2.29 69.1 8.8 No No
10 empty 2.02 70.5 7.3 No No
2H0R_A Nicotinamidase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 66.8 31.6 Yes No
2 empty 2.46 65.8 24.8 No No
3 empty 2.14 60.3 21.9 No No
4 empty 2.31 68.4 17.1 No No
5 empty 1.87 64.8 12.9 No No
6 empty 2.36 54.4 17.6 No No
7 empty 2.58 62.9 13.5 No No
8 empty 2.09 68.2 9.2 No No
9 empty 2.45 59.2 11.4 No No
10 empty 2.26 66.7 8.7 No No
2H0R_D Nicotinamidase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 65.8 35.4 Yes No
2 empty 2.39 66.4 25.3 No No
3 empty 2.26 61.5 27.1 No No
4 empty 2.24 52.9 15.8 No No
5 empty 1.87 68.2 10.7 No No
6 empty 2.51 65.3 10 No No
7 empty 2.34 67.4 14.3 No No
8 empty 2.63 63 12.3 No No
9 empty 2.1 54.4 8.9 No No
10 empty 2.22 66.5 9.5 No No
3V8E_A Nicotinamidase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 67.1 39.8 Yes No
2 empty 2.22 61.4 23.9 No No
3 empty 2.11 72.4 13.3 No No
4 empty 2.47 55.7 19.6 No No
5 empty 2.66 62.4 19.7 No No
6 empty 2.4 53.5 13.3 No No
7 empty 2.22 66.6 7.7 No No
8 empty 2.04 72 9.6 No No
9 empty 2.13 66.7 8.8 No No
10 empty 2.29 58.2 13.6 No No
3V8E_E Nicotinamidase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 67.8 40.1 Yes No
2 empty 2.24 63 21.1 No No
3 empty 2.06 70.6 18.3 No No
4 empty 2.27 52.4 14 No No
5 empty 1.94 66.9 9.8 No No
6 empty 2.8 62.5 13.8 No No
7 empty 2.02 72.9 11.3 No No
8 empty 2.22 69.1 9.2 No No
9 empty 2.63 56.6 10.8 No No
10 empty 2.41 61.3 13.5 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2H0R_A (3100608) Nicotinamidase Isochorismatase-like hydrolases, Isochorismatase-like hydrolases, UNMATCHED 2.9Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score