Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

PNC1 (P53184) - Overview - Molecular Target Synopsis


PNC1, Nicotinamidase
Enzyme Classification
UniProt P53184

Also Known as PNC1_YEAST, PNC1

Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: PNC1 is active in the following subcellular-locations: cytoplasm, nucleus, peroxisome.
GO terms: PNC1 is active in the following subcellular-locations: chromosome, cytoplasm, nucleus, peroxisome.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project PNC1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures

For PNC1 there are:
2 structures (14 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis