Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PNC1 (P53184) - Overview - Molecular Target Synopsis

Protein


PNC1, Nicotinamidase
Enzyme Classification 3.5.1.19
UniProt P53184

Also Known as PNC1_YEAST, PNC1

Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate.

3V8E
CRYSTAL STRUCTURE OF THE YEAST NICOTINAMIDASE PNC1P BOUND TO THE INHIBITOR NICOTINALDEHYDE
RCSB/PDB
Inspect Structure
See all 3D Structures for PNC1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
216P53184-1

Sub-cellular localization


UniProt: PNC1 is active in the following subcellular-locations: cytoplasm, nucleus, peroxisome.
GO terms: PNC1 is active in the following subcellular-locations: chromosome, cytoplasm, nucleus, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PNC1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For PNC1 there are:
2 structures (14 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis