Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Copy Number Variation
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Germline Genetics

MSH6 (P52701) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G27_A 40.54 3.0E-12 1.648Å EHE 2019-06-26
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKD_F 35.91 1.0E-53 7.6Å ANP 2015-07-22
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1NG9_A 35.28 2.0E-51 2.6Å ADP 2003-02-11
PWWP domain (68%) (view alignment) NSD2 (O96028) - HUMAN 5VC8_B 46.27 5.0E-13 1.8Å - 2017-06-28
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1WBD_A 35.57 3.0E-52 2.4Å ADP 2006-01-18
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKB_E 35.91 1.0E-53 4.71Å ANP 2015-07-22
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1E3M_B 35.57 3.0E-52 2.2Å - 2000-11-01
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G2C_A 40.54 3.0E-12 1.757Å EHT 2019-06-26
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKD_E 35.91 1.0E-53 7.6Å ANP 2015-07-22
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 6I5F_B 35.57 2.0E-52 2.6Å ADP 2019-08-14
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKC_F 35.91 1.0E-53 6.6Å ANP 2015-07-22
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G3P_C 40.54 3.0E-12 2.8Å - 2019-06-26
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKC_A 35.91 1.0E-53 6.6Å ANP 2015-07-22
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1E3M_A 35.57 3.0E-52 2.2Å ADP 2000-11-01
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 6I5F_A 35.57 2.0E-52 2.6Å ADP 2019-08-14
MutS domain III (26%), MutS family domain IV (46%), MutS domain V (100%) (view alignment) MSH2 (P43246) MSH6 (P52701) HUMAN 2O8C_A 36.02 1.0E-49 3.37Å ADP 2007-06-05
MutS domain III (26%), MutS family domain IV (46%), MutS domain V (100%) (view alignment) MSH2 (P43246) MSH3 (P20585) HUMAN 3THX_A 36.02 1.0E-49 2.7Å ADP 2011-12-21
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 3K0S_B 35.28 1.0E-51 2.2Å - 2010-02-16
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKC_J 35.91 1.0E-53 6.6Å ANP 2015-07-22
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 2WTU_B 35.57 3.0E-52 3.4Å - 2010-02-09
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 2WTU_A 35.57 3.0E-52 3.4Å ADP 2010-02-09
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1OH7_A 35.57 3.0E-52 2.5Å ADP 2003-08-08
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1OH6_A 35.57 3.0E-52 2.4Å ADP 2003-08-08
PWWP domain (100%) (view alignment) MSH6 (P52701) - HUMAN 6OQM_A 100 0 2.2Å - 2019-05-29
MutS domain III (26%), MutS family domain IV (46%), MutS domain V (100%) (view alignment) MSH2 (P43246) MSH6 (P52701) HUMAN 2O8D_A 36.02 1.0E-49 3Å ADP 2007-06-05
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKC_I 35.91 1.0E-53 6.6Å ANP 2015-07-22
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G2F_A 40.54 3.0E-12 1.738Å EHW 2019-06-26
MutS domain III (26%), MutS family domain IV (46%), MutS domain V (100%) (view alignment) MSH2 (P43246) MSH3 (P20585) HUMAN 3THW_A 36.02 1.0E-49 3.09Å ADP 2011-12-21
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G24_A 40.54 3.0E-12 2.1Å EH2 2019-06-26
MutS domain III (26%), MutS family domain IV (46%), MutS domain V (100%) (view alignment) MSH2 (P43246) MSH6 (P52701) HUMAN 2O8E_A 36.02 1.0E-49 3.3Å ADP 2007-06-05
MutS domain III (26%), MutS family domain IV (46%), MutS domain V (100%) (view alignment) MSH2 (P43246) MSH6 (P52701) HUMAN 2O8B_A 36.02 1.0E-49 2.75Å ADP 2007-06-05
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKC_B 35.91 1.0E-53 6.6Å ANP 2015-07-22
MutS domain III (26%), MutS family domain IV (46%), MutS domain V (100%) (view alignment) MSH2 (P43246) MSH6 (P52701) HUMAN 2O8F_A 36.02 1.0E-49 3.25Å ADP 2007-06-05
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1WB9_A 35.57 3.0E-52 2.1Å ADP 2006-01-18
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G3P_B 40.54 3.0E-12 2.8Å - 2019-06-26
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 3ZLJ_A 35.57 3.0E-52 3.1Å - 2013-07-17
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G29_A 40.54 3.0E-12 1.697Å EHK 2019-06-26
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G3T_D 40.54 3.0E-12 2.528Å EPE 2019-06-26
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1OH8_A 35.57 3.0E-52 2.9Å ADP 2003-08-08
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1OH6_B 35.57 3.0E-52 2.4Å - 2003-08-08
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G3T_A 40.54 3.0E-12 2.528Å EPE 2019-06-26
MutS domain I (100%), MutS domain II (100%), MutS domain III (100%), MutS family domain IV (100%), MutS domain V (100%) (view alignment) MSH6 (P52701) MSH2 (P43246) HUMAN 2O8E_B 100 0 3.3Å - 2007-06-05
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G2B_A 40.54 3.0E-12 1.607Å EH8 2019-06-26
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1WBB_B 35.57 3.0E-52 2.5Å - 2006-01-18
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G3T_C 40.54 3.0E-12 2.528Å - 2019-06-26
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1OH5_A 35.57 3.0E-52 2.9Å ADP 2003-08-08
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1W7A_A 35.57 3.0E-52 2.27Å ATP 2004-09-10
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1OH7_B 35.57 3.0E-52 2.5Å - 2003-08-08
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKB_A 35.91 1.0E-53 4.71Å ANP 2015-07-22
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKB_B 35.91 1.0E-53 4.71Å ANP 2015-07-22
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKD_I 35.91 1.0E-53 7.6Å ANP 2015-07-22
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G2O_A 40.54 3.0E-12 1.81Å EJE 2019-06-26
MutS domain I (100%), MutS domain II (100%), MutS domain III (100%), MutS family domain IV (100%), MutS domain V (100%) (view alignment) MSH6 (P52701) MSH2 (P43246) HUMAN 2O8B_B 100 0 2.75Å ADP 2007-06-05
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1WBB_A 35.57 3.0E-52 2.5Å ADP 2006-01-18
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1OH5_B 35.57 3.0E-52 2.9Å - 2003-08-08
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G25_A 40.54 3.0E-12 1.43Å EHQ 2019-06-26
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1W7A_B 35.57 3.0E-52 2.27Å ATP 2004-09-10
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1OH8_B 35.57 3.0E-52 2.9Å - 2003-08-08
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKD_B 35.91 1.0E-53 7.6Å ANP 2015-07-22
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 3K0S_A 35.28 1.0E-51 2.2Å ADP 2010-02-16
MutS domain III (26%), MutS family domain IV (46%), MutS domain V (100%) (view alignment) MSH2 (P43246) MSH3 (P20585) HUMAN 3THY_A 36.02 1.0E-49 2.89Å ADP 2011-12-21
PWWP domain (100%) (view alignment) MSH6 (P52701) - HUMAN 2GFU_A 100 0 - 2007-04-10
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G3P_D 40.54 3.0E-12 2.8Å - 2019-06-26
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1NG9_B 35.28 2.0E-51 2.6Å ADP 2003-02-11
MutS domain I (100%), MutS domain II (100%), MutS domain III (100%), MutS family domain IV (100%), MutS domain V (100%) (view alignment) MSH6 (P52701) MSH2 (P43246) HUMAN 2O8D_B 100 0 3Å ADP 2007-06-05
MutS domain I (100%), MutS domain II (100%), MutS domain III (100%), MutS family domain IV (100%), MutS domain V (100%) (view alignment) MSH6 (P52701) MSH2 (P43246) HUMAN 2O8F_B 100 0 3.25Å - 2007-06-05
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G3T_B 40.54 3.0E-12 2.528Å EPE 2019-06-26
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G2E_A 40.54 3.0E-12 1.848Å EHH 2019-06-26
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKD_J 35.91 1.0E-53 7.6Å ANP 2015-07-22
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1WB9_B 35.57 3.0E-52 2.1Å - 2006-01-18
PWWP domain (73%) (view alignment) NSD3 (Q9BZ95) - HUMAN 6G3P_A 40.54 3.0E-12 2.8Å - 2019-06-26
MutS domain I (100%), MutS domain II (100%), MutS domain III (100%), MutS family domain IV (100%), MutS domain V (100%) (view alignment) MSH6 (P52701) MSH2 (P43246) HUMAN 2O8C_B 100 0 3.37Å ADP 2007-06-05
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 1WBD_B 35.57 3.0E-52 2.4Å - 2006-01-18
PWWP domain (68%) (view alignment) NSD2 (O96028) - HUMAN 5VC8_A 46.27 5.0E-13 1.8Å - 2017-06-28
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKD_A 35.91 1.0E-53 7.6Å ANP 2015-07-22
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) mutL (P23367) 5AKC_E 35.91 1.0E-53 6.6Å ANP 2015-07-22
MutS domain III (26%), MutS family domain IV (46%), MutS domain V (100%) (view alignment) MSH2 (P43246) MSH3 (P20585) HUMAN 3THZ_A 36.02 1.0E-49 4.3Å ADP 2011-12-21
MutS domain III (23%), MutS family domain IV (37%), MutS domain V (100%) (view alignment) mutS (P23909) - 3ZLJ_B 35.57 3.0E-52 3.1Å - 2013-07-17