Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MSH6 (P52701) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed7
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria6


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6OQM_A DNA mismatch repair protein Msh6 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 59.2 21.1 No No
2 empty 2 69.9 11 No No
3 empty 2.55 55.6 15.9 No No
4 empty 2.11 56.4 12 No No
5 bound 2.23 66.8 10.9 No No
6 empty 1.96 67.4 10.4 No No
7 empty 2.07 61.5 9.6 No No
8 empty 2.13 71.4 6.8 No No
9 empty 1.34 57.3 7 No No
10 empty 2.65 71.7 6.7 No No
2O8E_B DNA mismatch repair protein Msh6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 72 62.4 Yes Yes
2 empty 1.82 69.4 53.2 No No
3 empty 1.96 72.4 48.6 No No
4 empty 1.87 65.3 43.2 No No
5 empty 2.08 69.2 42.9 No No
6 empty 2.08 63.7 28.5 No No
7 empty 1.86 73.8 17.8 No No
8 empty 1.86 64.4 30 No No
9 empty 2.16 67.5 26.7 No No
10 empty 2.29 68 27.3 No No
2O8B_B DNA mismatch repair protein Msh6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 69.4 33.5 Yes Yes
2 empty 1.91 65.5 46.7 No No
3 empty 1.91 71.1 31.4 No No
4 empty 1.84 60.4 45 No No
5 empty 1.84 64.9 35.3 No No
6 empty 2.11 63.4 24.8 No No
7 bound 2.23 56.1 23.6 No No
8 empty 1.76 64.4 21.9 No No
9 empty 1.9 74 16.6 No No
10 empty 1.86 65.7 16.5 No No
2GFU_A DNA mismatch repair protein Msh6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 62.4 25.8 Yes No
2 empty 1.57 58.1 14.8 No No
3 empty 2.28 65.5 11.3 No No
4 empty 2.14 61.7 12.5 No No
5 empty 2.34 65.9 14.8 No No
6 empty 1.78 73.2 10.6 No No
7 empty 2.53 68.9 9.1 No No
8 empty 2.19 67.5 10.1 No No
9 empty 2.59 76.8 4.9 No No
10 empty 2.01 66.2 7.1 No No
2O8D_B DNA mismatch repair protein Msh6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 69.7 38.9 Yes Yes
2 empty 1.9 72 30.9 No No
3 empty 1.91 66.4 42.8 No No
4 empty 2.06 63.3 44.2 No No
5 bound 2.29 59.9 33.1 No No
6 empty 2.23 65.4 19.8 No No
7 empty 1.89 71.5 20.5 No No
8 empty 2.02 64.7 19.3 No No
9 empty 2.12 69.8 19.4 No No
10 empty 1.77 61.4 20.7 No No
2O8F_B DNA mismatch repair protein Msh6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 72.5 52.9 Yes Yes
2 empty 2.01 74.6 54.1 No No
3 empty 1.88 68.4 58.8 No No
4 empty 2.24 65.9 60 No No
5 empty 1.84 66 47.3 No No
6 empty 2.08 64.8 31.7 No No
7 empty 2.31 73.1 21.6 No No
8 empty 2.04 63.3 22.9 No No
9 empty 1.77 62.6 30.6 No No
10 empty 2.11 57 18.7 No No
2O8C_B DNA mismatch repair protein Msh6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 65.2 58.6 Yes No
2 empty 1.86 72.6 32.1 No No
3 empty 1.83 66.9 44.5 No No
4 empty 1.8 61.6 44.2 No No
5 bound 2.27 58.5 30.4 No No
6 empty 1.91 63.6 32.7 No No
7 empty 2.24 67.2 20.6 No No
8 empty 2.2 64.4 26.6 No No
9 empty 1.81 61.4 26.6 No No
10 empty 1.88 72.7 14.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed21
Domains assessed as druggable using the strict criteria5
Domains assessed as druggable using the relaxed criteria20

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2GFU_A (3100033) DNA mismatch repair protein Msh6 SH3-like barrel, Tudor/PWWP/MBT, PWWP domain Yes No
2O8B_B (3160221) DNA mismatch repair protein Msh6 PFAM, PFAM, PFAM MutS_II 2.75Å No No
2O8B_B (3160223) DNA mismatch repair protein Msh6 DNA repair protein MutS domain III, DNA repair protein MutS domain III, DNA repair protein MutS domain III 2.75Å Yes Yes
2O8B_B (3160220) DNA mismatch repair protein Msh6 MutS N-terminal domain-like, DNA repair protein MutS domain I, UNMATCHED 2.75Å Yes No
2O8B_B (3160224) DNA mismatch repair protein Msh6 P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 2.75Å Yes No
2O8C_B (3160233) DNA mismatch repair protein Msh6 MutS N-terminal domain-like, DNA repair protein MutS domain I, UNMATCHED 3.37Å Yes No
2O8C_B (3160234) DNA mismatch repair protein Msh6 PFAM, PFAM, PFAM MutS_II 3.37Å Yes No
2O8C_B (3160236) DNA mismatch repair protein Msh6 DNA repair protein MutS domain III, DNA repair protein MutS domain III, DNA repair protein MutS domain III 3.37Å Yes No
2O8C_B (3160237) DNA mismatch repair protein Msh6 P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 3.37Å Yes No
2O8D_B (3160246) DNA mismatch repair protein Msh6 MutS N-terminal domain-like, DNA repair protein MutS domain I, UNMATCHED 3Å Yes No
2O8D_B (3160247) DNA mismatch repair protein Msh6 PFAM, PFAM, PFAM MutS_II 3Å Yes No
2O8D_B (3160250) DNA mismatch repair protein Msh6 P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 3Å Yes No
2O8D_B (3160249) DNA mismatch repair protein Msh6 DNA repair protein MutS domain III, DNA repair protein MutS domain III, DNA repair protein MutS domain III 3Å Yes Yes
2O8E_B (3160259) DNA mismatch repair protein Msh6 MutS N-terminal domain-like, DNA repair protein MutS domain I, UNMATCHED 3.3Å Yes No
2O8E_B (3160260) DNA mismatch repair protein Msh6 PFAM, PFAM, PFAM MutS_II 3.3Å Yes No
2O8E_B (3160262) DNA mismatch repair protein Msh6 DNA repair protein MutS domain III, DNA repair protein MutS domain III, DNA repair protein MutS domain III 3.3Å Yes Yes
2O8E_B (3160263) DNA mismatch repair protein Msh6 P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 3.3Å Yes No
2O8F_B (3160272) DNA mismatch repair protein Msh6 MutS N-terminal domain-like, DNA repair protein MutS domain I, UNMATCHED 3.25Å Yes No
2O8F_B (3160275) DNA mismatch repair protein Msh6 DNA repair protein MutS domain III, DNA repair protein MutS domain III, DNA repair protein MutS domain III 3.25Å Yes Yes
2O8F_B (3160273) DNA mismatch repair protein Msh6 PFAM, PFAM, PFAM MutS_II 3.25Å Yes No
2O8F_B (3160276) DNA mismatch repair protein Msh6 P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 3.25Å Yes Yes
Ligand-based Druggability Score: -0.95
Ligand-based Druggability Score Percentile: 69%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MSH6 is involved in 17 interactions in the network.


Druggability
Overall Druggability Percentile: 59.24
Druggability for Cancer Therapeutics: 92.66
Druggability for Other Therapeutics: 23.81
Cancer-Associated
Cancer-associated percentile : 98.20
Network Articulation Point
Is MSH6 critical for communication in the network?


Detailed Graph Legend:Help