Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(P52700) - Overview - Molecular Target Synopsis

Protein


, Metallo-beta-lactamase L1 type 3
Enzyme Classification 3.5.2.6
UniProt P52700

Also Known as BLA1_STEMA

Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Homotetramer.

5HH5
CRYSTAL STRUCTURE OF B3 METALLO-BETA-LACTAMASE L1 COMPLEXED WITH A PHOSPHONATE-BASED INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
290P52700-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: periplasm.
GO terms: is active in the following subcellular-locations: periplasmic space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
20 structures (35 chains) solved
14 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


has been screened with 163 compounds (242 bioactivities), 27 compounds have bioactivities that show binding affinity of <= 500nM (37 bioactivities). (see details)