Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC7A2 (P52569) - Overview - Molecular Target Synopsis

Protein


SLC7A2, Cationic amino acid transporter 2
UniProt P52569

Also Known as CTR2_HUMAN, SLC7A2, ATRC2, CAT2

Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC7A2 is active in the following subcellular-locations: cell membrane.
GO terms: SLC7A2 is active in the following subcellular-locations: cell junction, integral component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC7A2 has gain in 1 cell-lines, loss in 11 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H460, MCF7, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RMG-I, OVMANA, MCF-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, MCF-7, AG445

(see details)

3D Structures


At greater than 35% identity similarity to SLC7A2 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A2 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6F34_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC7A2 has been screened with compounds ( bioactivities). (see details)