Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

POLR2H (P52434) - Overview - Molecular Target Synopsis

Protein


POLR2H, DNA-directed RNA polymerases I, II, and III subunit RPABC3
UniProt P52434

Also Known as RPAB3_HUMAN, POLR2H

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A.

6DRD
RNA POL II(G)
RCSB/PDB
Inspect Structure
See all 3D Structures for POLR2H

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: POLR2H is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: POLR2H is active in the following subcellular-locations: cytosol, nucleoplasm, nucleus, protein-DNA complex, RNA polymerase I complex, RNA polymerase II, RNA polymerase III complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project POLR2H has gain in 10 cell-lines, loss in 1 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, MDA_MB_435, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G122, SCLC-22H, HT-1080

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, HMEC

(see details)

3D Structures


For POLR2H there are:
16 structures (16 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis