Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RND2 (P52198) - Overview - Molecular Target Synopsis

Protein


RND2, Rho-related GTP-binding protein RhoN
UniProt P52198

Also Known as RND2_HUMAN, RND2, ARHN, RHO7

May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily. Interacts with the Rho-GAP domain of RACGAP1 (PubMed:12590651). Interacts with UBXD5 (PubMed:11940653). Interacts with PRAG1.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
228ENSG00000108830ENST00000544533ENSP00000439328
227ENSG00000108830ENST00000587250ENSP00000466680P52198-1

Sub-cellular localization


UniProt: RND2 is active in the following subcellular-locations: acrosome membrane, cytoplasmic vesicle, secretory vesicle.
GO terms: RND2 is active in the following subcellular-locations: acrosomal membrane, cell cortex, cell division site, cytoplasm, early endosome, intracellular membrane-bounded organelle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RND2 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, OVCAR_8, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 273, HCC33, PA-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


At greater than 50% identity similarity to RND2 there are:
11 structures (16 chains) solved
11 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RND2 has been screened with compounds ( bioactivities). (see details)