NEK4 (P51957) - Overview - Molecular Target Synopsis
NEK4, Serine/threonine-protein kinase Nek4
Enzyme Classification 220.127.116.11
Also Known as NEK4_HUMAN, NEK4, STK2
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. Interacts with RPGRIP1 and RPGRIP1L.
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UniProt: NEK4 is active in the following subcellular-locations: cell projection, cilium, cytoplasm.
GO terms: NEK4 is active in the following subcellular-locations: ciliary basal body, ciliary plasm, ciliary rootlet, ciliary transition zone, cytoplasm, cytosol.