NEK3 (P51956) - Overview - Molecular Target Synopsis
NEK3, Serine/threonine-protein kinase Nek3
Enzyme Classification 220.127.116.11
Also Known as NEK3_HUMAN, NEK3
Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. Interacts with PXN, PRLR, VAV1 and VAV2 and this interaction is prolactin-dependent.
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UniProt: NEK3 is active in the following subcellular-locations: axon, cell projection, cytoplasm.
GO terms: NEK3 is active in the following subcellular-locations: axon, cytoplasm, nucleus.