Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GUCY2F (P51841) - Overview - Molecular Target Synopsis

Protein


GUCY2F, Retinal guanylyl cyclase 2
Enzyme Classification 4.6.1.2
UniProt P51841

Also Known as GUC2F_HUMAN, GUCY2F, GUC2F, RETGC2

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1108ENSG00000101890ENST00000218006ENSP00000218006P51841-1

Sub-cellular localization


UniProt: GUCY2F is active in the following subcellular-locations: membrane.
GO terms: GUCY2F is active in the following subcellular-locations: integral component of plasma membrane, nuclear outer membrane, photoreceptor disc membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GUCY2F has gain in 1 cell-lines, loss in 32 cell-lines and no signal in 970 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HL_60, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


GUCY2F was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MCF12A, OVMANA. (see details)

3D Structures


At greater than 35% identity similarity to GUCY2F there are:
14 structures (58 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GUCY2F has been screened with compounds ( bioactivities). (see details)