ADCY7 (P51828) - Overview - Molecular Target Synopsis
ADCY7, Adenylate cyclase type 7
Enzyme Classification 188.8.131.52
Also Known as ADCY7_HUMAN, ADCY7, KIAA0037
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|1080||ENSG00000121281||ENST00000394697, ENST00000254235||ENSP00000378187, ENSP00000254235||P51828-1|
UniProt: ADCY7 is active in the following subcellular-locations: membrane.
GO terms: ADCY7 is active in the following subcellular-locations: integral component of membrane, integral component of plasma membrane, plasma membrane.