Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AFF3 (P51826) - Overview - Molecular Target Synopsis

Protein


AFF3, AF4/FMR2 family member 3
UniProt P51826

Also Known as AFF3_HUMAN, AFF3, LAF4

Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AFF3 is active in the following subcellular-locations: nucleus.
GO terms: AFF3 is active in the following subcellular-locations: cytosol, ELL-EAF complex, nuclear body, nucleoplasm, nucleus, transcription elongation factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AFF3 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RXF_393, T47D, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, WSU-FSCCL, Toledo

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: AG445, CD20-positive B cell, BJ

(see details)


Screening and Chemistry


AFF3 has been screened with compounds ( bioactivities). (see details)