Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AFF1 (P51825) - Overview - Molecular Target Synopsis

Protein


AFF1, AF4/FMR2 family member 1
UniProt P51825

Also Known as AFF1_HUMAN, AFF1, AF4, FEL, MLLT2, PBM1

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3).

2LM0
SOLUTION STRUCTURE OF THE AF4-AF9 COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for AFF1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AFF1 is active in the following subcellular-locations: nucleus.
GO terms: AFF1 is active in the following subcellular-locations: ELL-EAF complex, nucleus, transcription elongation factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AFF1 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, MOLT_4, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H226, MHH-ES-1, WSU-FSCCL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HeLa-S3, NHLF

(see details)

3D Structures


For AFF1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AFF1 has been screened with compounds ( bioactivities). (see details)