Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AFF2 (P51816) - Overview - Molecular Target Synopsis

Protein


AFF2, AF4/FMR2 family member 2
UniProt P51816

Also Known as AFF2_HUMAN, AFF2, FMR2, OX19

RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AFF2 is active in the following subcellular-locations: nucleus speckle.
GO terms: AFF2 is active in the following subcellular-locations: nuclear speck, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AFF2 has gain in 0 cell-lines, loss in 24 cell-lines and no signal in 981 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: U-937, SU-DHL-16, RL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to AFF2 there are:
3 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AFF2 has been screened with compounds ( bioactivities). (see details)