Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GALK1 (P51570) - Overview - Molecular Target Synopsis

Protein


GALK1, Galactokinase
Enzyme Classification 2.7.1.6
UniProt P51570

Also Known as GALK1_HUMAN, GALK1, GALK

Major enzyme for galactose metabolism. Homodimer.

6QJE
STRUCTURE OF HUMAN GALACTOKINASE 1 BOUND WITH 4-{[2-(METHYLSULFONYL)- 1H-IMIDAZOL-1-YL]METHYL}-1,3-THIAZOLE
RCSB/PDB
Inspect Structure
See all 3D Structures for GALK1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: GALK1 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GALK1 has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_ADR_RES, SN12C, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BEN, MDA-MB-157, JHH-5

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HUVEC

(see details)

RNA Interference


GALK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL120, MDAMB157. (see details)

3D Structures


For GALK1 there are:
6 structures (24 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GALK1 has been screened with 20 compounds (32 bioactivities). (see details)