Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FABP6 (P51161) - Overview - Molecular Target Synopsis

Protein


FABP6, Gastrotropin
UniProt P51161

Also Known as FABP6_HUMAN, FABP6, ILBP, ILLBP

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity)., Isoform 2: Essential for the survival of colon cancer cells to bile acid-induced apoptosis.

5L8I
CRYSTAL STRUCTURE OF HUMAN FABP6 APO-PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for FABP6

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: FABP6 is active in the following subcellular-locations: cytoplasm, membrane.
GO terms: FABP6 is active in the following subcellular-locations: cytoplasm, cytosol, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FABP6 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_2, RXF_393, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1319, HCC1011, SNU-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For FABP6 there are:
6 structures (12 chains) solved
5 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

FABP6 is solved in complex with the approved drug(s):

CHD/CHOLIC ACID (5L8O_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FABP6 has been screened with compounds ( bioactivities). (see details)