Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB28 (P51157) - Overview - Molecular Target Synopsis

Protein


RAB28, Ras-related protein Rab-28
UniProt P51157

Also Known as RAB28_HUMAN, RAB28


3E5H
CRYSTAL STRUCTURE OF RAB28 GTPASE IN THE ACTIVE (GPPNHP-BOUND) FORM
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB28

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB28 is active in the following subcellular-locations: cell membrane, cilium basal body, cytoplasm, cytoskeleton.
GO terms: RAB28 is active in the following subcellular-locations: ciliary basal body, ciliary rootlet, cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB28 has gain in 3 cell-lines, loss in 3 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_MB_231, KM12, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TK, SU-DHL-1, NCI-H322T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, K562

(see details)

3D Structures


For RAB28 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB28 has been screened with compounds ( bioactivities). (see details)