Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB9A (P51151) - Overview - Molecular Target Synopsis

Protein


RAB9A, Ras-related protein Rab-9A
UniProt P51151

Also Known as RAB9A_HUMAN, RAB9A, RAB9

Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain) (PubMed:18243103, PubMed:16885419). Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:22637480). Interacts with SGSM2 (PubMed:21808068). The GTP-bound form but not the GDP-bound form interacts with HPS4 and BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (PubMed:20048159).

1WMS
HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN RAB9 GTPASE: A NOVEL ANTIVIRAL DRUG TARGET
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB9A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
215ENSG00000123595ENST00000464506ENSP00000420127
201P51151-1

Sub-cellular localization


UniProt: RAB9A is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, endoplasmic reticulum membrane, golgi apparatus membrane, late endosome, melanosome, phagosome, phagosome membrane.
GO terms: RAB9A is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, extracellular exosome, late endosome, lysosome, melanosome, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, trans-Golgi network membrane, transport vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB9A has gain in 1 cell-lines, loss in 54 cell-lines and no signal in 950 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, SK_OV_3, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: GTL-16, OVISE, MFM-223

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, HeLa-S3

(see details)

3D Structures


For RAB9A there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB9A is solved in complex with the approved drug(s):

BEZ/BENZOIC ACID (1S8F_A, 1S8F_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB9A has been screened with compounds ( bioactivities). (see details)