Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB5C (P51148) - Overview - Molecular Target Synopsis

Protein


RAB5C, Ras-related protein Rab-5C
UniProt P51148

Also Known as RAB5C_HUMAN, RAB5C, RABL

Protein transport. Probably involved in vesicular traffic. Interacts with EEA1 (PubMed:12493736). Interacts with INCA1 (PubMed:21750715).

4KYI
CRYSTAL STRUCTURE OF THE PHOSPHOLIPASE VIPD FROM LEGIONELLA PNEUMOPHILA IN COMPLEX WITH THE HUMAN GTPASE RAB5
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB5C

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB5C is active in the following subcellular-locations: cell membrane, early endosome membrane, melanosome.
GO terms: RAB5C is active in the following subcellular-locations: anchored component of synaptic vesicle membrane, azurophil granule membrane, early endosome, early endosome membrane, endocytic vesicle, endosome, extracellular exosome, lipid droplet, lysosomal membrane, melanosome, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB5C has gain in 1 cell-lines, loss in 4 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_62, SK_MEL_2, SF_295

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C32TG, JHH-4, MeWo

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, HUVEC

(see details)

3D Structures


For RAB5C there are:
2 structures (5 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB5C has been screened with compounds ( bioactivities). (see details)