Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

vatD (P50870) - Overview - Molecular Target Synopsis

Protein


vatD, Streptogramin A acetyltransferase
Enzyme Classification 2.3.1.-
UniProt P50870

Also Known as VATD_ENTFC, vatD, satA

Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics. Homohexamer.

3DHO
STRUCTURE OF STREPTOGRAMIN ACETYLTRANSFERASE IN COMPLEX WITH AN INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for vatD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
209P50870-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project vatD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For vatD there are:
8 structures (42 chains) solved
5 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

vatD is solved in complex with the approved drug(s):

DOL/DALFOPRISTIN (1MRL_A, 1MRL_B, 1MRL_C).

(see details)
Molecular Target 3D Synopsis