Molecular Target Synopsis
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METAP2 (P50579) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed32
Chains with at least one site assessed as druggable using the strict criteria19
Chains with at least one site assessed as druggable using the relaxed criteria32


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6QED_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.58 66.9 28.5 Yes Yes
2 bound 1.93 65.7 26.5 No No
3 empty 2.27 63.5 25.5 No No
4 bound 1.71 81.4 20.4 No No
5 empty 2.28 64.2 29.8 No No
6 empty 2.49 63.8 24.3 No No
7 bound 1.95 61.7 15.2 No No
8 empty 2.34 72.1 13.1 No No
9 empty 2.25 66.5 15.9 No No
10 empty 2.44 70.6 17.4 No No
1YW9_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 66.8 27.6 Yes Yes
2 bound 1.8 78.9 20.1 Yes Yes
3 empty 2.03 60.2 29.1 No No
4 empty 2.06 64.4 19.4 No No
5 empty 2.18 68.3 14.7 No No
6 empty 1.85 60.9 14.6 No No
7 empty 2.44 55.9 20.6 No No
8 empty 1.83 73.4 12.1 No No
9 empty 2.19 69.5 16.5 No No
10 empty 1.99 60.2 12.8 No No
1B6A_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 64.4 26.2 Yes No
2 bound 1.76 80 19.7 Yes Yes
3 empty 2.58 65.2 20.5 No No
4 empty 1.89 60.6 15.1 No No
5 empty 2.18 59.5 16.7 No No
6 empty 2.17 57.3 23.5 No No
7 empty 2.26 73.9 16.1 No No
8 empty 2.14 65.8 15.9 No No
9 empty 1.86 72.6 10 No No
10 empty 2.41 56.6 20.5 No No
2ADU_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 80.2 18.8 Yes Yes
2 empty 2.4 63.7 25.8 No No
3 empty 2.09 63.2 27.4 No No
4 empty 2.54 65.5 21 No No
5 empty 1.86 60.9 15.8 No No
6 empty 2.51 60.9 21.3 No No
7 empty 2.04 71.3 11.6 No No
8 empty 1.78 68 12.6 No No
9 empty 2.36 72.6 15.9 No No
10 empty 2.09 58.8 17.4 No No
1KQ9_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 73.6 30.9 Yes No
2 empty 2.21 64.1 36.1 No No
3 empty 2.66 65.9 24.8 No No
4 empty 1.91 64 25 No No
5 empty 2.46 57.9 20.8 No No
6 empty 2 70.4 11.1 No No
7 bound 1.76 72.2 12.2 No No
8 empty 2.43 72.5 16.5 No No
9 empty 2.24 64.5 15.3 No No
10 empty 2.28 70.5 13.6 No No
6QEI_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 66.2 30.6 Yes Yes
2 bound 1.7 78.8 26.3 Yes Yes
3 empty 2.31 64.6 34.8 No No
4 bound 1.75 67.2 38.3 No No
5 empty 1.75 59.6 15.1 No No
6 empty 2.18 63.9 18.8 No No
7 empty 2.2 68.8 12.8 No No
8 empty 2.31 81 11.7 No No
9 empty 2.15 59.3 17.1 No No
10 empty 2.52 60.9 14.9 No No
5D6E_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 65.9 29.2 Yes No
2 bound 1.7 79.4 26.1 Yes Yes
3 empty 2.01 63.2 23.5 No No
4 empty 2.28 65.7 23.4 No No
5 empty 2.44 65.1 20.3 No No
6 empty 1.76 62.3 15.8 No No
7 empty 2 65 19.7 No No
8 empty 2.23 70 16.8 No No
9 empty 1.71 67.5 17.2 No No
10 empty 2.03 66 11.3 No No
2GA2_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 63.4 27.8 Yes No
2 bound 1.76 77.9 19.9 No No
3 empty 2.08 60.1 27.5 No No
4 empty 2.43 60.8 22.9 No No
5 empty 1.85 59.4 15.6 No No
6 empty 2.54 64 18.2 No No
7 empty 2.06 63.8 18.6 No No
8 empty 1.99 67.2 16.4 No No
9 empty 1.76 68.5 17 No No
10 empty 2.29 72.6 15.9 No No
1R58_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 73.8 32.8 Yes No
2 empty 2.13 60.6 30.8 No No
3 empty 2.23 65.3 28.5 No No
4 empty 2.17 63.3 23 No No
5 empty 2.33 57.5 17.8 No No
6 empty 1.93 69 12.5 No No
7 empty 2.36 69.5 16.4 No No
8 empty 1.96 70.6 15.3 No No
9 empty 1.86 64.3 11.4 No No
10 empty 2.44 63 14.1 No No
2EA4_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 61.2 35.9 Yes No
2 bound 1.6 78.1 22.3 Yes No
3 empty 2.27 62.6 25 No No
4 empty 2.07 60.4 28.6 No No
5 empty 1.92 61.4 15.8 No No
6 empty 2.4 69.2 15.5 No No
7 empty 2.09 70.4 14.3 No No
8 empty 1.76 71.2 12.2 No No
9 empty 2.25 59.2 18.4 No No
10 empty 1.97 70.5 14.5 No No
1BN5_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 82.8 20.8 Yes Yes
2 empty 2.31 62.5 25.1 No No
3 empty 1.81 64.8 26.4 No No
4 bound 1.9 58.8 15.9 No No
5 empty 2.11 68.8 14.5 No No
6 empty 2.45 57.9 21.4 No No
7 empty 2.27 74.3 15.8 No No
8 empty 1.89 69.9 11.1 No No
9 empty 2.23 68 12.5 No No
10 empty 2.23 60.3 15.6 No No
1KQ0_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 79.7 21.8 Yes Yes
2 empty 2.26 63.2 30.2 No No
3 empty 1.88 64.5 26.4 No No
4 empty 1.86 60.1 15.5 No No
5 empty 2.16 66.1 16.1 No No
6 empty 2.21 74.3 16.4 No No
7 bound 1.79 71.3 12 No No
8 empty 2.41 55.1 21.4 No No
9 empty 2.07 60.2 13.4 No No
10 empty 2.31 62.3 16.2 No No
1BOA_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 79.9 21.6 Yes Yes
2 empty 2.26 61.9 22.3 No No
3 empty 1.96 61.6 19.8 No No
4 empty 1.9 60.5 15.8 No No
5 empty 2.31 76.4 15.5 No No
6 empty 1.87 71.5 9.9 No No
7 empty 2.23 67.8 20.9 No No
8 empty 2.18 72 16.5 No No
9 empty 2.35 61.4 15.9 No No
10 empty 2.18 62.1 16.4 No No
5JFR_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 65.4 43.5 Yes No
2 empty 2.17 66.4 30.7 No No
3 bound 1.74 80.8 18.5 No No
4 empty 2.13 60.8 28.5 No No
5 empty 2.53 61.9 26.4 No No
6 bound 1.88 62 13.4 No No
7 empty 2.21 65 19.3 No No
8 empty 2.48 62.7 25.5 No No
9 empty 1.85 68 18.6 No No
10 empty 2.21 66.6 17.2 No No
2EA2_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 64 27.4 Yes No
2 bound 1.72 80.4 21.8 Yes Yes
3 empty 2.23 59.3 28.3 No No
4 empty 2.12 64.5 23.6 No No
5 empty 2.11 61.9 18.7 No No
6 empty 1.88 62.4 15.4 No No
7 empty 2.38 57.9 21 No No
8 empty 2.01 69.9 16.9 No No
9 empty 2.12 70.8 12 No No
10 empty 1.91 67.5 18.3 No No
5CLS_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 79.6 26.1 Yes Yes
2 empty 2.04 63 24.6 No No
3 empty 2.52 63.6 27.2 No No
4 empty 2.24 64 30.8 No No
5 empty 2.18 66.4 15.1 No No
6 empty 1.95 61.2 14.8 No No
7 empty 2.4 70 16 No No
8 empty 2.22 68.3 15.8 No No
9 empty 1.66 69.7 12.6 No No
10 empty 2.13 65.7 18.4 No No
2OAZ_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 71.1 32 Yes No
2 empty 2.02 62.1 29.2 No No
3 empty 2.29 62.1 26.1 No No
4 empty 2.64 66.7 19.8 No No
5 empty 1.91 69.7 13.5 No No
6 empty 2.36 71.7 15.9 No No
7 empty 2.03 71.1 14.6 No No
8 empty 2.19 64.5 15.6 No No
9 empty 2.15 58.5 16.7 No No
10 empty 2.25 56.8 15.3 No No
6QEG_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 75.2 30.6 Yes No
2 bound 1.83 65.4 26.4 No No
3 empty 2.46 67.3 28.7 No No
4 empty 2.32 64.1 32.8 No No
5 empty 2.47 62.3 19.9 No No
6 empty 2.07 64.9 19.6 No No
7 empty 2.2 72.2 10.7 No No
8 empty 2.29 81.8 12.3 No No
9 empty 1.85 64.2 9.4 No No
10 empty 2.44 72.2 11.3 No No
6QEF_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 64.5 28.4 Yes No
2 bound 1.99 66 28.1 No No
3 empty 2.34 64.4 25.2 No No
4 empty 2.59 59.4 30.4 No No
5 bound 1.78 82.7 17.6 No No
6 empty 2.37 63.7 23.6 No No
7 empty 1.92 59.3 15.3 No No
8 empty 2 66.2 20.1 No No
9 empty 2.37 74.8 12.3 No No
10 bound 2.26 82.7 12.8 No No
1R5H_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.61 64.4 27.6 Yes No
2 bound 1.86 78.8 20.2 Yes Yes
3 empty 2.16 63.1 27.6 No No
4 empty 2.17 62.8 19 No No
5 empty 1.96 66.5 19.1 No No
6 empty 1.83 61.6 14.9 No No
7 empty 2.56 63.9 22.1 No No
8 empty 2.3 63.7 18.3 No No
9 empty 2.04 63.2 16.2 No No
10 empty 2.32 72.6 15.8 No No
5LYW_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 64.6 27.1 Yes No
2 bound 1.83 78.9 26.3 Yes Yes
3 empty 2.33 64.9 26.7 No No
4 empty 2.43 60.9 25.5 No No
5 empty 1.94 62.1 16.6 No No
6 empty 2.4 59.9 23.9 No No
7 empty 2.34 71.1 13.1 No No
8 empty 2.08 71.3 12.8 No No
9 empty 2.11 79.3 12.9 No No
10 empty 2.39 70.3 17.8 No No
6QEH_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 73.2 33.1 Yes No
2 bound 1.89 64.8 28.5 No No
3 empty 2.34 65.8 28.7 No No
4 empty 2.33 66.9 24.9 No No
5 empty 2.53 63 22.8 No No
6 empty 1.96 62.8 12.1 No No
7 empty 2.05 68.9 16.5 No No
8 empty 2.1 69.6 13.1 No No
9 empty 2.34 72.1 11.8 No No
10 empty 2.2 82 11.9 No No
1YW7_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 73.5 32.1 Yes No
2 empty 2.2 61.6 28.8 No No
3 empty 2.27 67.3 25.3 No No
4 empty 1.97 63.5 24.6 No No
5 empty 2.32 55.5 18 No No
6 empty 2.11 70.6 14.8 No No
7 empty 2.17 71.7 13.1 No No
8 empty 2.39 69.9 15.7 No No
9 empty 1.98 64.9 16.4 No No
10 empty 2.07 71.1 14.6 No No
1R5G_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 65.9 29.4 Yes No
2 bound 1.66 82 21.1 Yes Yes
3 empty 2.01 60.1 27.9 No No
4 empty 2.27 63.1 26.7 No No
5 empty 2.47 62.3 31 No No
6 empty 1.87 59.3 15.9 No No
7 empty 2.06 64.9 17.5 No No
8 empty 2.55 65 16.3 No No
9 empty 2.01 71.4 11.9 No No
10 empty 2.21 63.8 13.3 No No
5D6F_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 69.2 27.4 Yes Yes
2 bound 1.78 83.4 24.4 Yes Yes
3 empty 1.89 64.5 22.7 No No
4 empty 2.36 66.6 22.3 No No
5 empty 2.54 66 26.7 No No
6 bound 2.04 66.9 13.6 No No
7 empty 1.89 60.5 15.1 No No
8 empty 2.43 54.2 22.1 No No
9 empty 2.27 70.1 12.8 No No
10 empty 2.17 69.9 14.1 No No
1QZY_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 78.9 20.1 Yes Yes
2 empty 2.31 63.4 26.5 No No
3 empty 2.18 62.1 27.7 No No
4 empty 2.72 63.9 20.4 No No
5 bound 1.77 59.8 15.8 No No
6 empty 2.46 56.1 21.2 No No
7 empty 2.39 73.2 15.6 No No
8 empty 2.07 67.7 19.4 No No
9 empty 1.8 70.6 12.4 No No
10 empty 2.29 63.1 17.1 No No
6QEJ_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 66.1 20.7 No No
2 bound 1.83 80.5 20.8 Yes Yes
3 empty 2.28 67.4 19.8 No No
4 empty 1.78 64.9 26.2 No No
5 empty 2.54 63.1 20.1 No No
6 empty 1.73 63.8 15 No No
7 bound 1.82 70.9 11.2 No No
8 empty 2.51 71.8 15.1 No No
9 empty 2.3 71.2 15.8 No No
10 empty 2.2 66.6 17.4 No No
5JI6_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 66.3 29.5 Yes No
2 bound 1.74 77.4 18.8 Yes No
3 empty 2.23 64.2 34 No No
4 empty 2.09 61.6 28.4 No No
5 empty 2.44 58.9 22.2 No No
6 empty 2.19 67.4 15.3 No No
7 empty 1.84 59.9 15.2 No No
8 empty 2.29 74.4 15.5 No No
9 empty 2.21 69.6 15.3 No No
10 empty 1.93 69.9 11.6 No No
1B59_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 74.3 31.8 Yes No
2 empty 2.36 64.4 21.1 No No
3 empty 2.46 62.1 30.3 No No
4 empty 2.61 65.2 22.6 No No
5 empty 2.1 62.4 21.4 No No
6 empty 1.72 67.4 12 No No
7 empty 2.37 74.8 16.1 No No
8 empty 2.14 71.8 9.2 No No
9 empty 2.26 58.9 15.6 No No
10 empty 2.36 54.6 20 No No
5JHU_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 79.8 20.6 Yes Yes
2 empty 2.28 65.5 29.6 No No
3 empty 2.18 61.4 26.8 No No
4 empty 2.26 63.2 23.7 No No
5 empty 2.44 56.9 22.3 No No
6 bound 1.93 61.2 15 No No
7 empty 2.2 64.6 14.2 No No
8 empty 2.13 76.8 13.6 No No
9 empty 2.25 68.2 14.4 No No
10 empty 1.81 67.6 12.3 No No
1YW8_A Methionine aminopeptidase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 73.8 31.6 Yes No
2 empty 2.21 63.4 31.8 No No
3 empty 1.94 61.7 33.9 No No
4 empty 2.19 64.2 27.1 No No
5 empty 2.07 66.6 20.3 No No
6 empty 2.37 70.8 15.6 No No
7 empty 1.8 67 14.9 No No
8 empty 2.3 57.8 16.6 No No
9 empty 2.02 67.2 16.6 No No
10 empty 2.2 66.2 13.4 No No
5LYX_A Methionine aminopeptidase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 80.5 20.7 Yes Yes
2 empty 2.33 63.9 33.5 No No
3 empty 2.59 67.6 27 No No
4 empty 1.85 59.3 24.2 No No
5 empty 1.77 73.1 15.3 No No
6 empty 2.48 64.7 21.3 No No
7 empty 1.9 60 15.2 No No
8 empty 2.43 67.8 16.5 No No
9 empty 2.14 58 17.1 No No
10 empty 2.15 83.4 11.9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed36
Domains assessed as druggable using the strict criteria4
Domains assessed as druggable using the relaxed criteria19

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1B59_A (41162) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.8Å Yes No
1B59_A (16225) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.8Å No No
1B59_A (41162) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.8Å Yes No
1B6A_A (16223) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.58Å No No
1B6A_A (41160) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.58Å Yes No
1B6A_A (41160) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.58Å Yes No
1BN5_A (41161) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.8Å Yes Yes
1BN5_A (41161) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.8Å Yes Yes
1BN5_A (16224) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.8Å No No
1BOA_A (41163) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.8Å Yes No
1BOA_A (41163) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.8Å Yes No
1BOA_A (16226) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.8Å No No
1KQ0_A (91019) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2Å Yes No
1KQ0_A (91019) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2Å Yes No
1KQ0_A (91018) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 2Å No No
1KQ9_A (91022) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.9Å Yes No
1KQ9_A (91022) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.9Å Yes No
1KQ9_A (91021) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.9Å No No
1QZY_A (96718) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.6Å Yes Yes
1QZY_A (96717) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.6Å No No
1QZY_A (96718) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.6Å Yes Yes
1R58_A (111696) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.9Å Yes No
1R58_A (111695) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.9Å No No
1R58_A (111696) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.9Å Yes No
1R5G_A (111703) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2Å Yes No
1R5G_A (111703) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2Å Yes No
1R5G_A (111702) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 2Å No No
1R5H_A (111705) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2.4Å Yes No
1R5H_A (111704) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 2.4Å No No
1R5H_A (111705) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2.4Å Yes No
1YW7_A (124135) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.85Å Yes No
1YW7_A (124135) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.85Å Yes No
1YW7_A (124134) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.85Å No No
1YW8_A (124137) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2.65Å Yes No
1YW8_A (124136) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 2.65Å No No
1YW8_A (124137) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2.65Å Yes No
1YW9_A (124138) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.64Å No No
1YW9_A (124139) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.64Å Yes Yes
1YW9_A (124139) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.64Å Yes Yes
2ADU_A (126596) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.9Å Yes Yes
2ADU_A (126596) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.9Å Yes Yes
2ADU_A (126595) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.9Å No No
2EA2_A (146758) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2.5Å Yes No
2EA2_A (146758) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2.5Å Yes No
2EA2_A (146757) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 2.5Å No No
2EA4_A (146760) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2.35Å Yes No
2EA4_A (146760) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 2.35Å Yes No
2EA4_A (146759) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 2.35Å No No
2GA2_A (134853) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.95Å Yes No
2GA2_A (134852) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.95Å No No
2GA2_A (134853) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.95Å Yes No
2OAZ_A (139000) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.9Å Yes No
2OAZ_A (139000) Methionine aminopeptidase 2 Creatinase/aminopeptidase, Creatinase/aminopeptidase, Creatinase/aminopeptidase 1.9Å Yes No
2OAZ_A (138999) Methionine aminopeptidase 2 DNA/RNA-binding 3-helical bundle, Winged helix DNA-binding domain, Methionine aminopeptidase insert domain 1.9Å Yes No
Ligand-based Druggability Score: 1.7
Ligand-based Druggability Score Percentile: 96%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


METAP2 is involved in 10 interactions in the network.


Druggability
Overall Druggability Percentile: 78.17
Druggability for Cancer Therapeutics: 80.40
Druggability for Other Therapeutics: 72.36
Cancer-Associated
Cancer-associated percentile : 78.19
Network Articulation Point
Is METAP2 critical for communication in the network?


Detailed Graph Legend:Help